The late phase of preconditioning and its natural clinical application--gene therapy.

abstract：:The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are freq...

journal_title：Heart failure reviews

authors： Rocchiccioli JP,McMurray JJ,Dominiczak AF

更新日期：2010-07-01 00:00:00

abstract：:The discovery of cardiac natriuretic peptides two decades ago has lead to considerable research to investigate their biochemical and physiological properties. Clearly the heart is not just a pump but is also an endocrine organ that together with the kidneys control volume overload. The natriuretic peptides are a group...

journal_title：Heart failure reviews

authors： Azzazy HM,Christenson RH

更新日期：2003-10-01 00:00:00

abstract：:Stem cell therapy is a promising approach to the treatment of ischemic heart disease via replenishing cell loss after myocardial infarction. Both preclinical studies and clinical trials have indicated that cardiac function improved consistently, but very modestly after cell-based therapy. This mainly attributed to low...

journal_title：Heart failure reviews

authors： Huang P,Tian X,Li Q,Yang Y

更新日期：2016-11-01 00:00:00

abstract：:Heart failure is a complex disease process, the manifestation of various cardiac and noncardiac abnormalities. General treatment approaches for heart failure have remained the same over the past decades despite the advent of novel therapies and monitoring modalities. In the same vein, the readmission rates for heart f...

journal_title：Heart failure reviews

authors： Njoroge JN,Cheema B,Ambrosy AP,Greene SJ,Collins SP,Vaduganathan M,Mebazaa A,Chioncel O,Butler J,Gheorghiade M

更新日期：2018-07-01 00:00:00

abstract：:Descriptions of the pathophysiology of heart failure have gone through a substantial evolution in the last 50 years. It is now recognised that heart failure can occur in the presence and also in the absence of a reduction in left ventricular function. In the former situation, this classically has been described to lea...

journal_title：Heart failure reviews

authors： Dorhout Mees EJ

更新日期：2013-07-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a subcategory of pulmonary hypertension (PH) that comprises a group of disorders with similar pulmonary vascular pathology. Though PH is common, the estimated incidence of IPAH is 1-3 cases per million, making it a rare disease. The hemodynamic definition of PAH is a mean pulmo...

journal_title：Heart failure reviews

authors： Awdish R,Cajigas H

更新日期：2016-05-01 00:00:00

abstract：:Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...

journal_title：Heart failure reviews

authors： Ruggeri C,Gioffré S,Achilli F,Colombo GI,D'Alessandra Y

更新日期：2018-01-01 00:00:00

abstract：:The pathophysiology of heart failure (HF) is characterized by an abnormal activation of neurohumoral systems, including the sympathetic nervous and the renin-angiotensin-aldosterone systems, which have long-term deleterious effects on the disease progression. Perpetuation of this neurohumoral activation is partially d...

journal_title：Heart failure reviews

authors： Sousa-Pinto B,Ferreira-Pinto MJ,Santos M,Leite-Moreira AF

更新日期：2014-11-01 00:00:00

abstract：:Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims to highlight the...

journal_title：Heart failure reviews

authors： Dhesi P,Tehrani F,Fuess J,Schwarz ER

更新日期：2010-01-01 00:00:00

abstract：:Acute heart failure syndromes (AHFS) are associated with the rapid onset of heart failure (HF) signs and symptoms. Hospitalizations for AHFS continue to rise and are associated with significant mortality and morbidity. Several pharmacological agents are currently approved for the treatment of AHFS, but their use is as...

journal_title：Heart failure reviews

authors： Khan H,Metra M,Blair JE,Vogel M,Harinstein ME,Filippatos GS,Sabbah HN,Porchet H,Valentini G,Gheorghiade M

更新日期：2009-12-01 00:00:00

abstract：:It is over 4 years since the Prospective Comparison of angiotensin receptor/neprilysin inhibitor (ARNI) with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial was published in New England Journal of Medicine. The PARADIGM-HF trial was the one that contributed to the offici...

journal_title：Heart failure reviews

authors： Książczyk M,Lelonek M

更新日期：2020-05-01 00:00:00

abstract：:Previous studies have reported superiority of mechanistic target-of-rapamycin (mTOR) antagonists (mTA) over calcineurin inhibitors (CNI) as part of maintenance immunosuppression (IS) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). MEDLINE and EMBASE were searched through October 20...

journal_title：Heart failure reviews

authors： Ueyama H,Kuno T,Takagi H,Alvarez P,Asleh R,Briasoulis A

更新日期：2020-05-18 00:00:00

abstract：:Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix. In this regard, STAT3 i...

journal_title：Heart failure reviews

authors： Haghikia A,Stapel B,Hoch M,Hilfiker-Kleiner D

更新日期：2011-01-01 00:00:00

abstract：:Despite remarkable progress in the therapeutic approach of patients with chronic heart failure (CHF), exercise intolerance remains one of the hallmarks of the disease. During the past two decades, evidence has accumulated to underscore the key role of both endothelial dysfunction and skeletal muscle wasting in the pro...

journal_title：Heart failure reviews

authors： Conraads VM,Van Craenenbroeck EM,De Maeyer C,Van Berendoncks AM,Beckers PJ,Vrints CJ

更新日期：2013-01-01 00:00:00

abstract：:Heart failure (HF) is characterized by the elaboration of a portfolio of pro-inflammatory cytokines and inflammatory mediators that are considered to contribute to disease progression by virtue of the deleterious effects that these molecules exert on the heart and circulation. Recent studies have suggested that these ...

journal_title：Heart failure reviews

authors： Bozkurt B,Mann DL,Deswal A

更新日期：2010-07-01 00:00:00

abstract：:The evolving paradigm of heart failure has now been expanded to include the favorable neurohormonal, structural and hemodynamic profile of B-type natriuretic peptide [BNP]. As a marker of left ventricular dysfunction, BNP is a practical tool that facilitates diagnosis, contributes to prognostic evaluations and tracks ...

journal_title：Heart failure reviews

authors： Yancy CW

更新日期：2003-10-01 00:00:00

abstract：:There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially im...

journal_title：Heart failure reviews

authors： Mikhailov AT,Torrado M

更新日期：2016-11-01 00:00:00

abstract：:End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible...

journal_title：Heart failure reviews

authors： Butler CR,Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:The aging population with hypertension and coronary artery disease is rapidly increasing worldwide and develops heart failure (HF). A wide range of pharmacotherapeutic drugs are recommended in the HF management guidelines. For the most part, these recommendations are based on the results of studies in the younger popu...

journal_title：Heart failure reviews

authors： Man JP,Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Diabetes mellitus is a chronic disease requiring lifelong control with hypoglycemic agents that must demonstrate excellent efficacy and safety profiles. In patients taking glucose-lowering drugs, hypoglycemia is a common cause of death associated with arrhythmias, increased thrombus formation, and specific effects of ...

journal_title：Heart failure reviews

authors： Anfinogenova Y,Grakova EV,Shvedova M,Kopieva KV,Teplyakov AT,Popov SV

更新日期：2018-05-01 00:00:00

abstract：:β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors known as G protein-coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for the activation of adenylyl cyclase (AC) yielding cyclic AMP (CAMP), and this provides valuable responses, which can affect the cardiac function such as...

journal_title：Heart failure reviews

authors： Ali DC,Naveed M,Gordon A,Majeed F,Saeed M,Ogbuke MI,Atif M,Zubair HM,Changxing L

更新日期：2020-03-01 00:00:00

abstract：:Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate ...

journal_title：Heart failure reviews

authors： Sieniewicz BJ,Gould J,Porter B,Sidhu BS,Teall T,Webb J,Carr-White G,Rinaldi CA

更新日期：2019-01-01 00:00:00

abstract：:Ultrafiltration (UF) has emerged as an alternative therapy for acute decompensated heart failure (ADHF) due to its physiological benefits such as improvement in neurohormonal activation. We performed a systematic review and a meta-analysis to evaluate the efficacy, safety, and the impact on outcomes for UF therapy as ...

journal_title：Heart failure reviews

authors： Jain A,Agrawal N,Kazory A

更新日期：2016-09-01 00:00:00

abstract：:Diabetes is a global epidemic and a leading cause of death with more than 422 million patients worldwide out of whom around 392 million alone suffer from type 2 diabetes (T2D). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel and effective drugs in managing glycemia of T2D patients. These inhibitors gained...

journal_title：Heart failure reviews

authors： Kaplan A,Abidi E,El-Yazbi A,Eid A,Booz GW,Zouein FA

更新日期：2018-05-01 00:00:00

abstract：:Significant growth in the elderly population (age ≥ 65 years) with heart failure (HF) has taken place in developed countries and is occurring in most developing countries. Projections from population studies in the United States, Europe and other developed countries suggest that this trend will very likely continue an...

journal_title：Heart failure reviews

authors： Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Depression is associated with an increased risk of death in patients with heart failure (HF); however, the association between the use of antidepressants and HF prognoses remains controversial. Therefore, this meta-analysis aimed to evaluate the effect of antidepressants on the risk of death in HF patients. We retriev...

journal_title：Heart failure reviews

authors： He W,Zhou Y,Ma J,Wei B,Fu Y

更新日期：2020-11-01 00:00:00

abstract：:Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms characterized by different numbers of amino acids. The number of amino acids in the active isoforms range from 36 to 12. Apelin-13 and, to a lesser extent, apelin-36 are considered the most active isoforms with the greatest act...

journal_title：Heart failure reviews

authors： Folino A,Montarolo PG,Samaja M,Rastaldo R

更新日期：2015-07-01 00:00:00

abstract：:Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact ro...

journal_title：Heart failure reviews

authors： Kobak KA,Radwańska M,Dzięgała M,Kasztura M,Josiak K,Banasiak W,Ponikowski P,Jankowska EA

更新日期：2019-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, with co-morbidities contributing to the overall severity and mortality of the disease. The incidence and prevalence of cardiovascular disease among COPD patients are high. Both disorders often co-exist, mainly due to smoking, but they al...

journal_title：Heart failure reviews

authors： Petta V,Perlikos F,Loukides S,Bakakos P,Chalkias A,Iacovidou N,Xanthos T,Tsekoura D,Hillas G

更新日期：2017-11-01 00:00:00

abstract：:Heart failure (HF) is a chronic, systemic disorder that presents a serious and growing public health problem due to its high prevalence, mortality, and cost of care. Due to the aging of the population and medical advances that prolong the life of HF patients, more effective, widespread strategies for improved HF manag...

journal_title：Heart failure reviews

authors： Abu-Sawwa R,Dunbar SB,Quyyumi AA,Sattler ELP

更新日期：2019-07-01 00:00:00