Abstract：
:End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible for heart transplantation because of their age and comorbidities, and the application of mechanical circulatory support for destination therapy in this population is not well defined. A review of the literature was undertaken to better characterize our experience to date with mechanical circulatory support in older heart failure populations. Mechanical circulatory support is being employed increasingly for destination therapy indications in older patients. The newer continuous flow devices appear to have disproportionate advantage in elderly patients, which has translated into marked improvement in 1- and 2-year survival. The rational implementation of MCS devices in elderly heart failure patients needs to focus on (1) continuous flow devices that appear to have particular benefit in this population, (2) extensive pre-MCS assessment including variables relating to frailty, and (3) intervening before these patients develop cardiogenic shock. More data are needed on the cost-benefit analysis of routine use of CF devices as destination therapy in elderly patients with heart failure.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Butler CR,Jugdutt BIdoi
10.1007/s10741-012-9298-ysubject
Has Abstractpub_date
2012-09-01 00:00:00pages
663-9issue
4-5eissn
1382-4147issn
1573-7322journal_volume
17pub_type
杂志文章,评审abstract：:Healing after myocardial infarction (MI) is a well-orchestrated time-dependent process that involves inflammation, tissue repair with extracellular collagen matrix (ECCM) deposition and scar formation, and remodeling of myocardial structure, matrix, vasculature, and function. Rapid early ECCM degradation followed by s...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9090-1
更新日期：2008-12-01 00:00:00
abstract：:The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are t...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9747-3
更新日期：2019-03-01 00:00:00
abstract：:Heart failure with preserved ejection fraction (HFpEF) accounts for almost one-half of all heart failure (HF) patients and continues to increase in prevalence. While mortality with heart failure with reduced ejection fraction (HFrEF) has decreased over the past few decades with use of evidence-based HFrEF therapy, mor...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09958-4
更新日期：2020-05-13 00:00:00
abstract：:Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix. In this regard, STAT3 i...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9170-x
更新日期：2011-01-01 00:00:00
abstract：:Although mineralocorticoid antagonists (MRAs) have been proposed as effective fourth-line blood pressure (BP) lowering agents in resistant hypertension, this effect in heart failure is undetermined. In this synthesis of heart failure randomized controlled trials (RCTs), we evaluated the extent of BP lowering following...
journal_title：Heart failure reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10741-018-9689-9
更新日期：2018-07-01 00:00:00
abstract：:It is now clear that diastolic heart failure (DHF) is an important, perhaps even dominant form of heart failure in older Americans. However, our knowledge base regarding the epidemiology, pathophysiology, natural history, and therapy of this relatively recently recognized disorder is limited. A number of normal age re...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1013745705318
更新日期：2002-01-01 00:00:00
abstract：:Brief ischemia to the myocardium initiates a cascade of biochemical events in cardiac myocytes that protects the heart muscle during subsequent ischemic insults. This phenomenon is called ischemic preconditioning. If an acute myocardial infarction is preceded by preinfarction angina, it results in smaller infarction s...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-007-9037-y
更新日期：2007-12-01 00:00:00
abstract：:Patients diagnosed with CHF have disproportionately high rates of depression. Research has demonstrated significant consequences of depression in patients with CHF including poor quality of life, worse medical adherence and increased health complications, health care utilization, and medical costs. Despite these conse...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9081-2
更新日期：2009-03-01 00:00:00
abstract：:The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9225-z
更新日期：2012-03-01 00:00:00
abstract：:Myocarditis (MCD) is a type of inflammatory disease in which inflammatory cells infiltrate the myocardium, leading to cardiac dysfunction, myocardial necrosis, and fibrosis. Although it has been reported that MCD is mediated by T cells, the immune system is complex and includes many types of immune cells that interact...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-019-09799-w
更新日期：2019-11-01 00:00:00
abstract：:There is ongoing controversy regarding the association between loop diuretics (LD), especially in high doses, and adverse clinical outcomes in outpatients with heart failure (HF). We performed a systematic review of the evidence for LD in outpatients with HF. We searched MEDLINE, EMBASE, and Cochrane Clinical Trial Co...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09995-z
更新日期：2020-06-21 00:00:00
abstract：:This collection of papers covers developments in a rapidly growing area, sarcomeric proteins in hypertrophied and failing myocardium. Advances in our understanding of the biochemistry and biophysics of crossbridge cycling, contributions of thick versus thin filament and the emerging role of titin, the importance and m...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-005-5247-3
更新日期：2005-09-01 00:00:00
abstract：:Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims to highlight the...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-009-9137-y
更新日期：2010-01-01 00:00:00
abstract：:Acute heat failure syndromes are a heterogenous group of conditions. Chronic heart failure exacerbations represent the vast majority of cases. Pathophysiologic mechanisms, such as hypotension with peripheral tissue hypoperfusion, renal function impairment and myocardial ischemia and injury, adversely affect patients' ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-007-9014-5
更新日期：2007-06-01 00:00:00
abstract：:To determine and address medication non-adherence is important and may improve patient outcomes. Our aim was to perform a systematic review on the operationalization of adherence measures in patients with heart failure using claims data. We searched the MEDLINE, EMBASE, and Cochrane databases. A quality check of the f...
journal_title：Heart failure reviews
pub_type： 杂志文章
doi：10.1007/s10741-017-9656-x
更新日期：2018-01-01 00:00:00
abstract：:Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic function, which leaves the heart unable to pump enough blood to meet the normal physiological requirements of the human body. It is a serious disease burden worldwide affecting nearly 23 million patients. The concept that he...
journal_title：Heart failure reviews
pub_type： 杂志文章
doi：10.1007/s10741-018-9713-0
更新日期：2019-01-01 00:00:00
abstract：:The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in r...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9663-y
更新日期：2018-01-01 00:00:00
abstract：:Cardiac hypertrophy is promoted by adrenergic over-activation and represents an independent risk factor for cardiovascular morbidity and mortality. The basic knowledge about mechanisms by which sustained adrenergic activation promotes myocardial growth, as well as understanding how structural changes in hypertrophied ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-007-9007-4
更新日期：2007-03-01 00:00:00
abstract：:The spectrum of ischemic heart diseases, encompassing acute myocardial infarction to heart failure, represents the leading cause of death worldwide. Although extensive progress in cardiovascular diagnoses and therapy has been made, the prevalence of the disease continues to increase. Cardiac regeneration has a promisi...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09953-9
更新日期：2020-04-18 00:00:00
abstract：:Due to the recent advances in diagnosis and management of patients with HER2-positive breast cancer, especially through novel HER2-targeted agents, cardiotoxicity becomes an emerging problem. Although chemotherapy significantly increases survival, the risk of cardiovascular disease development is high and still undere...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-10072-8
更新日期：2021-01-06 00:00:00
abstract：:Since its discovery in 1988, there has been increasing evidence that endothelin-1 (ET-1) plays an important role in the pathophysiology of hypertension and its related end-organ damages. First studies, using ET-1 administration in animals or in humans suspected this role by demonstrating the hypertensive properties of...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1011419223152
更新日期：2001-12-01 00:00:00
abstract：:Dramatic advances in molecular biology dominated twentieth century biomedical science and delineated the function of individual genes and molecules in exquisite detail. However, biological processes cannot be fully understood based on the properties of individual genes and molecules alone, since these elements act in ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-009-9138-x
更新日期：2010-07-01 00:00:00
abstract：:In this paper, two different aspects of the relationship between chronic kidney disease and sudden cardiac death (SCD) have been reviewed. In end-stage renal disease patients, SCD risk is increased, and among patients implanted with a cardioverter defibrillator (ICD), dialysed ones carry a superior relative risk compa...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9210-6
更新日期：2011-11-01 00:00:00
abstract：:This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect on the binding of T3 to thyroid ho...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9131-9
更新日期：2010-03-01 00:00:00
abstract：:Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive, life-threatening disease characterized by deposition of insoluble amyloid fibrils in the myocardium, resulting in cardiac structural and functional abnormalities and ultimately heart failure. Disease frequency is reportedly lower in women than men, but s...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-10010-8
更新日期：2021-01-01 00:00:00
abstract：:Heart failure (HF) is the leading cause of hospitalization in the USA. Despite advances in pharmacologic management, the incidence of HF is on the rise and survivability is persistently reduced. Sympathetic overdrive is implicated in the pathophysiology of HF, particularly HF with reduced ejection fraction (HFrEF). Ta...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9680-5
更新日期：2018-07-01 00:00:00
abstract：:B-Type natriuretic peptide (BNP) is elevated in states of increased ventricular wall stress. BNP is most commonly used to rule out congestive heart failure (CHF) in dyspneic patients. BNP levels are influenced by age, gender and, to a surprisingly large extent, by body mass index (BMI). In addition, it can be elevated...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-007-9002-9
更新日期：2007-03-01 00:00:00
abstract：:Acute heart failure syndromes (AHFS) are associated with the rapid onset of heart failure (HF) signs and symptoms. Hospitalizations for AHFS continue to rise and are associated with significant mortality and morbidity. Several pharmacological agents are currently approved for the treatment of AHFS, but their use is as...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-009-9136-z
更新日期：2009-12-01 00:00:00
abstract：:Heart failure (HF) is a chronic, systemic disorder that presents a serious and growing public health problem due to its high prevalence, mortality, and cost of care. Due to the aging of the population and medical advances that prolong the life of HF patients, more effective, widespread strategies for improved HF manag...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-019-09781-6
更新日期：2019-07-01 00:00:00
abstract：:Chronic heart failure (CHF) is a multi-dimensional and complex syndrome. Outcome measures are important for determining both the efficacy and quality of care and capturing the patient's perspective in evaluating the outcomes of health care delivery. Capturing the patient's perspective via patient-reported outcomes is ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9369-0
更新日期：2014-03-01 00:00:00
