Cardiotoxicity in HER2-positive breast cancer patients.

Abstract:

:Due to the recent advances in diagnosis and management of patients with HER2-positive breast cancer, especially through novel HER2-targeted agents, cardiotoxicity becomes an emerging problem. Although chemotherapy significantly increases survival, the risk of cardiovascular disease development is high and still underestimated and could imply treatment discontinuation. Frequently, due to lack of rigorous diagnosis strategies, cardiotoxicity assessment is delayed, and, moreover, the efficacy of current therapy options in restoring heart function is questionable. For a comprehensive risk assessment, it is vital to characterize the clinical spectrum of HER2-targeted agents and anthracyclines, as well as their pathogenic pathways involved in cardiotoxicity. Advanced cardiovascular multimodal imaging and circulating biomarkers plays primary roles in early assessing cardiotoxicity and also in guiding specific preventive measures. Even though the knowledge in this field is rapidly expanding, there are still questions that arise regarding the optimal approach in terms of timing and methods. The aim of the current review aims to providean overview of currently available data.

journal_name

Heart Fail Rev

journal_title

Heart failure reviews

authors

Gonciar D,Mocan L,Zlibut A,Mocan T,Agoston-Coldea L

doi

10.1007/s10741-020-10072-8

subject

Has Abstract

pub_date

2021-01-06 00:00:00

eissn

1382-4147

issn

1573-7322

pii

10.1007/s10741-020-10072-8

pub_type

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