Pleiotropic effects of cardiac drugs on healing post-MI. The good, bad, and ugly.

abstract：:Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by neoplastic transformation of pluripotent cells due to a typical cytogenetic and molecular mutation known as Philadelphia (Ph) chromosome. In 2001, the introduction of the tyrosine kinasis inhibitor (TKI) imatinib as a therapeutic strategy...

journal_title：Heart failure reviews

authors： Casavecchia G,Galderisi M,Novo G,Gravina M,Santoro C,Agricola E,Capalbo S,Zicchino S,Cameli M,De Gennaro L,Righini FM,Monte I,Tocchetti CG,Brunetti ND,Cadeddu C,Mercuro G

更新日期：2020-05-01 00:00:00

abstract：:Heart failure (HF) is the leading cause of hospitalization in the USA. Despite advances in pharmacologic management, the incidence of HF is on the rise and survivability is persistently reduced. Sympathetic overdrive is implicated in the pathophysiology of HF, particularly HF with reduced ejection fraction (HFrEF). Ta...

journal_title：Heart failure reviews

authors： Devgun J,Jobanputra YB,Arustamyan M,Chait R,Ghumman W

更新日期：2018-07-01 00:00:00

abstract：:Sodium glucose cotransporter 2 (SGLT2) inhibitors reduce the rate of hospitalization for heart failure in individuals with type 2 diabetes, but the underlying mechanisms remain elusive. Modestly elevated circulating β-hydroxybutyrate (βOHB) during treatment with SGLT2 inhibitors causes different beneficial effects on ...

journal_title：Heart failure reviews

authors： Hattori Y

更新日期：2020-05-01 00:00:00

abstract：:Ultrafiltration (UF) has emerged as an alternative therapy for acute decompensated heart failure (ADHF) due to its physiological benefits such as improvement in neurohormonal activation. We performed a systematic review and a meta-analysis to evaluate the efficacy, safety, and the impact on outcomes for UF therapy as ...

journal_title：Heart failure reviews

authors： Jain A,Agrawal N,Kazory A

更新日期：2016-09-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is a common disorder generating high mortality and important morbidity prevalence, with a very limited medical treatment available. Studies have shown that the pathophysiological hallmark of this condition is an elevated left intra-atrial pressure (LAP), exertiona...

journal_title：Heart failure reviews

authors： Burlacu A,Simion P,Nistor I,Covic A,Tinica G

更新日期：2019-09-01 00:00:00

abstract：:Heart failure continues to be associated with high morbidity and mortality. Over the past decade, left ventricular assist devices have been shown to improve the survival and quality of life. However, it is quite clear that very sick patients do not do as well, and it is therefore imperative to select patients at the p...

journal_title：Heart failure reviews

authors： Gilotra NA,Russell SD

更新日期：2013-01-01 00:00:00

abstract：:In addition to functional alterations, heart failure has a structural basis as well. This concerns all components of the cardiac myocytes as well as the extracellular space. Proteins of the cardiomyocyte can be subdivided in 5 different categories: 1) Contractile proteins including myosin, actin, tropomyosin and the t...

journal_title：Heart failure reviews

authors： Kostin S,Hein S,Arnon E,Scholz D,Schaper J

更新日期：2000-10-01 00:00:00

abstract：:Cardiopulmonary exercise testing (CPET) is a procedure widely used in daily clinical activity to investigate cardiac and pulmonary disorders. Peak oxygen consumption (VO2 peak) is the most validated and clinically accepted parameter used to report aerobic capacity in healthy individuals and in different clinical setti...

journal_title：Heart failure reviews

authors： Gargiulo P,Olla S,Boiti C,Contini M,Perrone-Filardi P,Agostoni P

更新日期：2014-09-01 00:00:00

abstract：:Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarct...

journal_title：Heart failure reviews

authors： Pereira RM,Mekary RA,da Cruz Rodrigues KC,Anaruma CP,Ropelle ER,da Silva ASR,Cintra DE,Pauli JR,de Moura LP

更新日期：2018-01-01 00:00:00

abstract：:Heart failure (HF) is a common complication in patients with type 2 diabetes and it is closely associated with high morbidity and mortality rate. The incidence of cardiovascular events in patients with diabetes is related to high levels of glycemia, expressed by increase of HbA1c levels. However, there is little evide...

journal_title：Heart failure reviews

authors： Palazzuoli A,Ceccarelli E,Ruocco G,Nuti R

更新日期：2018-05-01 00:00:00

abstract：:Many factors contribute to the pathophysiology and progression of heart failure (HF), offering the potential for many synergistic therapeutic approaches to its management. For patients, who have systolic HF, prolonged QRS and receiving guideline-indicated pharmacological therapy, cardiac resynchronization therapy (CRT...

journal_title：Heart failure reviews

authors： Buga L

更新日期：2012-11-01 00:00:00

abstract：:The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in r...

journal_title：Heart failure reviews

authors： Singh RM,Waqar T,Howarth FC,Adeghate E,Bidasee K,Singh J

更新日期：2018-01-01 00:00:00

abstract：:Cor pulmonale is the condition in which the right ventricle undergoes morphological and/or functional changes due to diseases that affect the lungs, the pulmonary circulation, or the breathing process. Depending on the speed of onset of the pathological condition and subsequent effects on the right ventricle, it is po...

journal_title：Heart failure reviews

authors： Mandoli GE,Sciaccaluga C,Bandera F,Cameli P,Esposito R,D'Andrea A,Evola V,Sorrentino R,Malagoli A,Sisti N,Nistor D,Santoro C,Bargagli E,Mondillo S,Galderisi M,Cameli M,Working group of Echocardiography of Italian Society

更新日期：2020-08-29 00:00:00

abstract：:Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure...

journal_title：Heart failure reviews

authors： Zizola C,Schulze PC

更新日期：2013-09-01 00:00:00

abstract：:In the United States and Europe, approximately 90% of heart failure hospitalizations are due to symptoms and signs of sodium and fluid excess. Congestion is associated with heart failure progression. Venous congestion, rather than a reduced cardiac output, may be the primary hemodynamic factor driving worsening renal ...

journal_title：Heart failure reviews

authors： Costanzo MR,Jessup M

更新日期：2012-03-01 00:00:00

abstract：:There was a mistake in Prof. Giuseppe Massimo Claudio Rosano's affiliation. ...

journal_title：Heart failure reviews

authors： Mascolo A,Urbanek K,De Angelis A,Sessa M,Scavone C,Berrino L,Rosano GMC,Capuano A,Rossi F

更新日期：2020-09-01 00:00:00

abstract：:Myocarditis (MCD) is a type of inflammatory disease in which inflammatory cells infiltrate the myocardium, leading to cardiac dysfunction, myocardial necrosis, and fibrosis. Although it has been reported that MCD is mediated by T cells, the immune system is complex and includes many types of immune cells that interact...

journal_title：Heart failure reviews

authors： Hua X,Song J

更新日期：2019-11-01 00:00:00

abstract：:In this paper, two different aspects of the relationship between chronic kidney disease and sudden cardiac death (SCD) have been reviewed. In end-stage renal disease patients, SCD risk is increased, and among patients implanted with a cardioverter defibrillator (ICD), dialysed ones carry a superior relative risk compa...

journal_title：Heart failure reviews

authors： Padeletti L,Innocenti L,Paoletti Perini A,Gronda E

更新日期：2011-11-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) represents one of the primary cardiomyopathies and may lead to heart failure and sudden death. Until recently, ventricular arrhythmias were considered to be a direct consequence of the systolic dysfunction of the left ventricle (LV) and guidelines for implantable cardioverter defibrillator...

journal_title：Heart failure reviews

authors： Zegkos T,Panagiotidis T,Parcharidou D,Efthimiadis G

更新日期：2020-02-13 00:00:00

abstract：:There is ongoing controversy regarding the association between loop diuretics (LD), especially in high doses, and adverse clinical outcomes in outpatients with heart failure (HF). We performed a systematic review of the evidence for LD in outpatients with HF. We searched MEDLINE, EMBASE, and Cochrane Clinical Trial Co...

journal_title：Heart failure reviews

authors： Kapelios CJ,Bonou Μ,Malliaras K,Athanasiadi E,Vakrou S,Skouloudi M,Masoura C,Barbetseas J

更新日期：2020-06-21 00:00:00

abstract：:The discovery of cardiac natriuretic peptides two decades ago has lead to considerable research to investigate their biochemical and physiological properties. Clearly the heart is not just a pump but is also an endocrine organ that together with the kidneys control volume overload. The natriuretic peptides are a group...

journal_title：Heart failure reviews

authors： Azzazy HM,Christenson RH

更新日期：2003-10-01 00:00:00

abstract：:Chronic heart failure (CHF) is a multi-dimensional and complex syndrome. Outcome measures are important for determining both the efficacy and quality of care and capturing the patient's perspective in evaluating the outcomes of health care delivery. Capturing the patient's perspective via patient-reported outcomes is ...

journal_title：Heart failure reviews

authors： Chang S,Newton PJ,Inglis S,Luckett T,Krum H,Macdonald P,Davidson PM

更新日期：2014-03-01 00:00:00

abstract：:The abnormal regulation of nitric oxide synthase activity represents an underlying feature of heart failure. Increased peripheral vascular resistance, and decreased renal function may be in part related to impaired endothelium-dependent nitric oxide (NO) synthesis. Paradoxically, the chronic production of NO by induci...

journal_title：Heart failure reviews

authors： Calderone A

更新日期：2003-01-01 00:00:00

abstract：:It is now clear that diastolic heart failure (DHF) is an important, perhaps even dominant form of heart failure in older Americans. However, our knowledge base regarding the epidemiology, pathophysiology, natural history, and therapy of this relatively recently recognized disorder is limited. A number of normal age re...

journal_title：Heart failure reviews

authors： Kitzman DW

更新日期：2002-01-01 00:00:00

abstract：:Significant growth in the elderly population (age ≥ 65 years) with heart failure (HF) has taken place in developed countries and is occurring in most developing countries. Projections from population studies in the United States, Europe and other developed countries suggest that this trend will very likely continue an...

journal_title：Heart failure reviews

authors： Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a subcategory of pulmonary hypertension (PH) that comprises a group of disorders with similar pulmonary vascular pathology. Though PH is common, the estimated incidence of IPAH is 1-3 cases per million, making it a rare disease. The hemodynamic definition of PAH is a mean pulmo...

journal_title：Heart failure reviews

authors： Awdish R,Cajigas H

更新日期：2016-05-01 00:00:00

abstract：:Nitric oxide degradation linked to endothelial dysfunction plays a central role in cardiovascular diseases. Superoxide producing enzymes such as NADPH oxidase and xanthine oxidase are responsible for NO degradation as they generate a variety of reactive oxygen species (ROS). Moreover, superoxide is rapidly degraded by...

journal_title：Heart failure reviews

authors： de Gasparo M

更新日期：2002-10-01 00:00:00

abstract：:Accumulation of macrophages within the artery wall is an eminent feature of atherosclerotic plaques. Macrophages are influenced by various plaque microenvironmental stimuli, such as oxidized lipids, cytokines, and senescent erythrocytes, and thereby polarize into two main phenotypes called proinflammatory M1 and anti-...

journal_title：Heart failure reviews

authors： Momtazi-Borojeni AA,Abdollahi E,Nikfar B,Chaichian S,Ekhlasi-Hundrieser M

更新日期：2019-05-01 00:00:00

abstract：:Acute heart failure hospitalizations complicated by diuretic resistance are associated with worse outcomes. Yet, quantification of the frequency and accompanying risk from loop diuretic resistance is limited by the absence of a comprehensive definition with universal clinical application. Herein, we outline limitation...

journal_title：Heart failure reviews

authors： Cox ZL,Testani JM

更新日期：2020-01-01 00:00:00

abstract：:Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, i...

journal_title：Heart failure reviews

authors： Danziger RS

更新日期：2008-09-01 00:00:00