Insulin resistance and heart failure during treatment with sodium glucose cotransporter 2 inhibitors: proposed role of ketone utilization.

abstract：:The sympathetic nervous system provides the most powerful stimulation of cardiac function, brought about via norepinephrine and epinephrine and their postsynaptic beta-adrenergic receptors. More than 30 years after the first use of practolol in patients with heart failure beta blockers are now the mainstay of the phar...

journal_title：Heart failure reviews

authors： El-Armouche A,Eschenhagen T

更新日期：2009-12-01 00:00:00

abstract：:Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...

journal_title：Heart failure reviews

authors： Ruggeri C,Gioffré S,Achilli F,Colombo GI,D'Alessandra Y

更新日期：2018-01-01 00:00:00

abstract：:The aging population with hypertension and coronary artery disease is rapidly increasing worldwide and develops heart failure (HF). A wide range of pharmacotherapeutic drugs are recommended in the HF management guidelines. For the most part, these recommendations are based on the results of studies in the younger popu...

journal_title：Heart failure reviews

authors： Man JP,Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Patients diagnosed with CHF have disproportionately high rates of depression. Research has demonstrated significant consequences of depression in patients with CHF including poor quality of life, worse medical adherence and increased health complications, health care utilization, and medical costs. Despite these conse...

journal_title：Heart failure reviews

authors： O'Hea E,Houseman J,Bedek K,Sposato R

更新日期：2009-03-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by neoplastic transformation of pluripotent cells due to a typical cytogenetic and molecular mutation known as Philadelphia (Ph) chromosome. In 2001, the introduction of the tyrosine kinasis inhibitor (TKI) imatinib as a therapeutic strategy...

journal_title：Heart failure reviews

authors： Casavecchia G,Galderisi M,Novo G,Gravina M,Santoro C,Agricola E,Capalbo S,Zicchino S,Cameli M,De Gennaro L,Righini FM,Monte I,Tocchetti CG,Brunetti ND,Cadeddu C,Mercuro G

更新日期：2020-05-01 00:00:00

abstract：:Nitric oxide degradation linked to endothelial dysfunction plays a central role in cardiovascular diseases. Superoxide producing enzymes such as NADPH oxidase and xanthine oxidase are responsible for NO degradation as they generate a variety of reactive oxygen species (ROS). Moreover, superoxide is rapidly degraded by...

journal_title：Heart failure reviews

authors： de Gasparo M

更新日期：2002-10-01 00:00:00

abstract：:There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially im...

journal_title：Heart failure reviews

authors： Mikhailov AT,Torrado M

更新日期：2016-11-01 00:00:00

abstract：:The prognosis for patients with congestive heart failure (CHF) has been improved as a result of the use of angiotensin converting enzyme inhibitors and beta-adrenergic receptor blockers. The success of these therapies underscores the pathogenic role of neurohormonal activation in CHF. Clinical and experimental evidenc...

journal_title：Heart failure reviews

authors： Kan H,Finkel MS

更新日期：2001-03-01 00:00:00

abstract：:The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are freq...

journal_title：Heart failure reviews

authors： Rocchiccioli JP,McMurray JJ,Dominiczak AF

更新日期：2010-07-01 00:00:00

abstract：:Previous studies have reported superiority of mechanistic target-of-rapamycin (mTOR) antagonists (mTA) over calcineurin inhibitors (CNI) as part of maintenance immunosuppression (IS) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). MEDLINE and EMBASE were searched through October 20...

journal_title：Heart failure reviews

authors： Ueyama H,Kuno T,Takagi H,Alvarez P,Asleh R,Briasoulis A

更新日期：2020-05-18 00:00:00

abstract：:In addition to functional alterations, heart failure has a structural basis as well. This concerns all components of the cardiac myocytes as well as the extracellular space. Proteins of the cardiomyocyte can be subdivided in 5 different categories: 1) Contractile proteins including myosin, actin, tropomyosin and the t...

journal_title：Heart failure reviews

authors： Kostin S,Hein S,Arnon E,Scholz D,Schaper J

更新日期：2000-10-01 00:00:00

abstract：:Cell transplantation is emerging as a new treatment designed tot improve the poor outcome of patients with cardiac failure. Its rationale is that implantation of contractile cells into postinfarction scars can functionally rejuvenate these areas. Primarily for practical reasons, autologous skeletal myoblasts have been...

journal_title：Heart failure reviews

authors： Menasché P

更新日期：2003-07-01 00:00:00

abstract：:Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix. In this regard, STAT3 i...

journal_title：Heart failure reviews

authors： Haghikia A,Stapel B,Hoch M,Hilfiker-Kleiner D

更新日期：2011-01-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) represents one of the primary cardiomyopathies and may lead to heart failure and sudden death. Until recently, ventricular arrhythmias were considered to be a direct consequence of the systolic dysfunction of the left ventricle (LV) and guidelines for implantable cardioverter defibrillator...

journal_title：Heart failure reviews

authors： Zegkos T,Panagiotidis T,Parcharidou D,Efthimiadis G

更新日期：2020-02-13 00:00:00

abstract：:Functional capacity represents an important predictor for cardiovascular and all-cause mortality in patients with diabetes mellitus (DM). Impaired cardiopulmonary fitness is frequently seen in DM patients, and it might partly explain morbidity and mortality in these patients. There are several potential reasons that c...

journal_title：Heart failure reviews

authors： Tadic M,Grassi G,Cuspidi C

更新日期：2020-08-15 00:00:00

abstract：:We aimed to study the cardiovascular and economic burden of diabetes mellitus (DM) in patients hospitalized for heart failure (HF) in the US and to assess the recent temporal trend. Data from the National Inpatient Sample were analyzed between 2005 and 2014. The prevalence of DM increased from 40.4 to 46.5% in patient...

journal_title：Heart failure reviews

authors： Mekhaimar M,Dargham S,El-Shazly M,Al Suwaidi J,Jneid H,Abi Khalil C

更新日期：2020-09-15 00:00:00

abstract：:Diabetes mellitus is a chronic disease requiring lifelong control with hypoglycemic agents that must demonstrate excellent efficacy and safety profiles. In patients taking glucose-lowering drugs, hypoglycemia is a common cause of death associated with arrhythmias, increased thrombus formation, and specific effects of ...

journal_title：Heart failure reviews

authors： Anfinogenova Y,Grakova EV,Shvedova M,Kopieva KV,Teplyakov AT,Popov SV

更新日期：2018-05-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is a common disorder generating high mortality and important morbidity prevalence, with a very limited medical treatment available. Studies have shown that the pathophysiological hallmark of this condition is an elevated left intra-atrial pressure (LAP), exertiona...

journal_title：Heart failure reviews

authors： Burlacu A,Simion P,Nistor I,Covic A,Tinica G

更新日期：2019-09-01 00:00:00

abstract：:Patients suffering from congestive heart failure exhibit impaired myocardial energy production, myocyte calcium overload and increased oxidative stress. Nutritional factors known to be important for myocardial energy production, calcium homeostasis and the reduction of oxidative stress, such as thiamine, riboflavin, p...

journal_title：Heart failure reviews

authors： Allard ML,Jeejeebhoy KN,Sole MJ

更新日期：2006-03-01 00:00:00

abstract：:It is well established that cardiac remodeling plays a pivotal role in the development of heart failure, a leading cause of death worldwide. Meanwhile, sympathetic hyperactivity is an important factor in inducing cardiac remodeling. Therefore, an in-depth understanding of beta-adrenoceptor signaling pathways would hel...

journal_title：Heart failure reviews

authors： Yang J,Liu Y,Fan X,Li Z,Cheng Y

更新日期：2014-11-01 00:00:00

abstract：:Cardiopulmonary exercise testing (CPET) is a procedure widely used in daily clinical activity to investigate cardiac and pulmonary disorders. Peak oxygen consumption (VO2 peak) is the most validated and clinically accepted parameter used to report aerobic capacity in healthy individuals and in different clinical setti...

journal_title：Heart failure reviews

authors： Gargiulo P,Olla S,Boiti C,Contini M,Perrone-Filardi P,Agostoni P

更新日期：2014-09-01 00:00:00

abstract：:End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible...

journal_title：Heart failure reviews

authors： Butler CR,Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Heart failure (HF) is a common complication in patients with type 2 diabetes and it is closely associated with high morbidity and mortality rate. The incidence of cardiovascular events in patients with diabetes is related to high levels of glycemia, expressed by increase of HbA1c levels. However, there is little evide...

journal_title：Heart failure reviews

authors： Palazzuoli A,Ceccarelli E,Ruocco G,Nuti R

更新日期：2018-05-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) accounts for almost one-half of all heart failure (HF) patients and continues to increase in prevalence. While mortality with heart failure with reduced ejection fraction (HFrEF) has decreased over the past few decades with use of evidence-based HFrEF therapy, mor...

journal_title：Heart failure reviews

authors： Moustafa A,Khan MS,Alsamman MA,Jamal F,Atalay MK

更新日期：2020-05-13 00:00:00

abstract：:The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are t...

journal_title：Heart failure reviews

authors： Singh RB,Hristova K,Fedacko J,El-Kilany G,Cornelissen G

更新日期：2019-03-01 00:00:00

abstract：:Due to the recent advances in diagnosis and management of patients with HER2-positive breast cancer, especially through novel HER2-targeted agents, cardiotoxicity becomes an emerging problem. Although chemotherapy significantly increases survival, the risk of cardiovascular disease development is high and still undere...

journal_title：Heart failure reviews

authors： Gonciar D,Mocan L,Zlibut A,Mocan T,Agoston-Coldea L

更新日期：2021-01-06 00:00:00

abstract：:Cardiac magnetic resonance spectroscopy (MRS) is a noninvasive method to assess by-products of myocardial metabolism. Recent developments in shorter scan protocols and more powerful field strengths have created interest in utilizing this technology in studying and characterizing the metabolic derangements in heart fai...

journal_title：Heart failure reviews

authors： Qureshi WT,Nasir UB

更新日期：2017-07-01 00:00:00

abstract：:This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect on the binding of T3 to thyroid ho...

journal_title：Heart failure reviews

authors： Wiersinga WM

更新日期：2010-03-01 00:00:00

abstract：:The abnormal regulation of nitric oxide synthase activity represents an underlying feature of heart failure. Increased peripheral vascular resistance, and decreased renal function may be in part related to impaired endothelium-dependent nitric oxide (NO) synthesis. Paradoxically, the chronic production of NO by induci...

journal_title：Heart failure reviews

authors： Calderone A

更新日期：2003-01-01 00:00:00

abstract：:Uric acid, the metabolic mediator of gout and urate renal stones, is associated with increased cardiovascular risk burden. Hyperuricemia is an old emerging metabolic disorder, and interaction among uric acid and cardiovascular diseases has been clearly described. Several illness including hypertension, myocardial infa...

journal_title：Heart failure reviews

authors： Borghi C,Palazzuoli A,Landolfo M,Cosentino E

更新日期：2020-01-01 00:00:00