Abstract:
:The abnormal regulation of nitric oxide synthase activity represents an underlying feature of heart failure. Increased peripheral vascular resistance, and decreased renal function may be in part related to impaired endothelium-dependent nitric oxide (NO) synthesis. Paradoxically, the chronic production of NO by inducible nitric oxide synthase (iNOS) in heart failure exerts deleterious effects on ventricular contractility, and circulatory function. Consequently, pharmacologically improving endothelium-dependent NO synthesis and the concomitant inhibition of iNOS activity would be therapeutically advantageous. Interestingly, natriuretic peptides have been shown to differentially regulate endothelial NOS (eNOS) and iNOS activity. Moreover, in both patients and animal models of heart failure, pharmacologically increasing plasma natriuretic peptide levels ameliorated vascular tone, renal function, and ventricular contractility. Based on these observations, the following review will explore whether the therapeutic benefit of the natriuretic peptide system in heart failure may occur in part via the amelioration of endothelium-dependent NO synthesis, and the concomitant inhibition of cytokine-mediated iNOS expression.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Calderone Adoi
10.1023/a:1022147005110subject
Has Abstractpub_date
2003-01-01 00:00:00pages
55-70issue
1eissn
1382-4147issn
1573-7322pii
5114467journal_volume
8pub_type
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-005-2347-z
更新日期:2005-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-009-9137-y
更新日期:2010-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-009-9138-x
更新日期:2010-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9298-y
更新日期:2012-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09926-y
更新日期:2020-05-01 00:00:00
abstract::In response to a prolonged pressure- or volume-overload, alterations occur in myocardial fatty acid, glucose, and glycogen metabolism. Oxidation of long chain fatty acids has been found to be reduced in hypertrophied hearts compared to non-hypertrophied hearts. However, this observation depends upon the degree of card...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1015380609464
更新日期:2002-04-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-018-9734-8
更新日期:2019-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-006-9195-3
更新日期:2006-03-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/A:1009813621103
更新日期:2000-10-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-013-9417-4
更新日期:2014-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9619-2
更新日期:2017-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-011-9278-7
更新日期:2012-09-01 00:00:00
abstract::Ultrafiltration (UF) has emerged as an alternative therapy for acute decompensated heart failure (ADHF) due to its physiological benefits such as improvement in neurohormonal activation. We performed a systematic review and a meta-analysis to evaluate the efficacy, safety, and the impact on outcomes for UF therapy as ...
journal_title:Heart failure reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10741-016-9559-2
更新日期:2016-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9626-3
更新日期:2017-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9046-x
更新日期:2009-03-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-008-9132-8
更新日期:2009-12-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 已发布勘误
doi:10.1007/s10741-020-10000-w
更新日期:2020-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9324-0
更新日期:2013-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9654-z
更新日期:2018-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09882-2
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1023/A:1009880720032
更新日期:2000-06-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1023/a:1011406022657
更新日期:2001-09-01 00:00:00
abstract::Chronic heart failure (CHF) is a multi-dimensional and complex syndrome. Outcome measures are important for determining both the efficacy and quality of care and capturing the patient's perspective in evaluating the outcomes of health care delivery. Capturing the patient's perspective via patient-reported outcomes is ...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9369-0
更新日期:2014-03-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-018-9747-3
更新日期:2019-03-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-10004-6
更新日期:2021-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-005-6801-8
更新日期:2004-10-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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