Abstract:
:Patients suffering from congestive heart failure exhibit impaired myocardial energy production, myocyte calcium overload and increased oxidative stress. Nutritional factors known to be important for myocardial energy production, calcium homeostasis and the reduction of oxidative stress, such as thiamine, riboflavin, pyridoxine, L-carnitine, coenzyme Q10, creatine and taurine are reduced in this patient population. Furthermore, deficiencies of taurine, carnitine, and thiamine are established primary causes of dilated cardiomyopathy. Studies in animals and limited trials in humans have shown that dietary replacement of some of these compounds in heart failure can significantly restore depleted levels and may result in improvement in myocardial structure and function as well as exercise capacity. Larger scale studies examining micronutrient depletion in heart failure patients, and the benefits of dietary replacement need to be performed. At the present time, it is our belief that these conditioned nutritional requirements, if unsatisfied, contribute to myocyte dysfunction and loss; thus, restoration of nutritional deficiencies should be part of the overall therapeutic strategy for patients with congestive heart failure.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Allard ML,Jeejeebhoy KN,Sole MJdoi
10.1007/s10741-006-9195-3subject
Has Abstractpub_date
2006-03-01 00:00:00pages
75-82issue
1eissn
1382-4147issn
1573-7322journal_volume
11pub_type
杂志文章,评审abstract::β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors known as G protein-coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for the activation of adenylyl cyclase (AC) yielding cyclic AMP (CAMP), and this provides valuable responses, which can affect the cardiac function such as...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09825-x
更新日期:2020-03-01 00:00:00
abstract::Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9653-0
更新日期:2018-01-01 00:00:00
abstract::Patients diagnosed with CHF have disproportionately high rates of depression. Research has demonstrated significant consequences of depression in patients with CHF including poor quality of life, worse medical adherence and increased health complications, health care utilization, and medical costs. Despite these conse...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-008-9081-2
更新日期:2009-03-01 00:00:00
abstract::In the past decade, cardiac pacing devices (either permanent pacemakers or Implanted Cardioverter Defibrillators) have become increasingly common in patients with heart failure. The manner in which the device is programmed to pace the heart can have significant implications on cardiac hemodynamics, both positive and n...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-011-9239-1
更新日期:2011-09-01 00:00:00
abstract::Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms characterized by different numbers of amino acids. The number of amino acids in the active isoforms range from 36 to 12. Apelin-13 and, to a lesser extent, apelin-36 are considered the most active isoforms with the greatest act...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-015-9475-x
更新日期:2015-07-01 00:00:00
abstract::Acute heat failure syndromes are a heterogenous group of conditions. Chronic heart failure exacerbations represent the vast majority of cases. Pathophysiologic mechanisms, such as hypotension with peripheral tissue hypoperfusion, renal function impairment and myocardial ischemia and injury, adversely affect patients' ...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9014-5
更新日期:2007-06-01 00:00:00
abstract::Although mineralocorticoid antagonists (MRAs) have been proposed as effective fourth-line blood pressure (BP) lowering agents in resistant hypertension, this effect in heart failure is undetermined. In this synthesis of heart failure randomized controlled trials (RCTs), we evaluated the extent of BP lowering following...
journal_title:Heart failure reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10741-018-9689-9
更新日期:2018-07-01 00:00:00
abstract::Depression is associated with an increased risk of death in patients with heart failure (HF); however, the association between the use of antidepressants and HF prognoses remains controversial. Therefore, this meta-analysis aimed to evaluate the effect of antidepressants on the risk of death in HF patients. We retriev...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09850-w
更新日期:2020-11-01 00:00:00
abstract::The prognosis for patients with congestive heart failure (CHF) has been improved as a result of the use of angiotensin converting enzyme inhibitors and beta-adrenergic receptor blockers. The success of these therapies underscores the pathogenic role of neurohormonal activation in CHF. Clinical and experimental evidenc...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1011405926588
更新日期:2001-03-01 00:00:00
abstract::Heart failure (HF) is the leading cause of hospitalization in the USA. Despite advances in pharmacologic management, the incidence of HF is on the rise and survivability is persistently reduced. Sympathetic overdrive is implicated in the pathophysiology of HF, particularly HF with reduced ejection fraction (HFrEF). Ta...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-018-9680-5
更新日期:2018-07-01 00:00:00
abstract::Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, i...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9061-y
更新日期:2008-09-01 00:00:00
abstract::Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic function, which leaves the heart unable to pump enough blood to meet the normal physiological requirements of the human body. It is a serious disease burden worldwide affecting nearly 23 million patients. The concept that he...
journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1007/s10741-018-9713-0
更新日期:2019-01-01 00:00:00
abstract::The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in r...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9663-y
更新日期:2018-01-01 00:00:00
abstract::Cardiac hypertrophy (CH) is generally considered adaptive responses that may occur after myocardial infarction, pressure overload, volume overload, inflammatory heart muscle disease, or idiopathic dilated cardiomyopathy, whereas long-term stimulation eventually leads to heart failure (HF). However, the current molecul...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09882-2
更新日期:2020-11-01 00:00:00
abstract::Diabetes is a global epidemic and a leading cause of death with more than 422 million patients worldwide out of whom around 392 million alone suffer from type 2 diabetes (T2D). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel and effective drugs in managing glycemia of T2D patients. These inhibitors gained...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9665-9
更新日期:2018-05-01 00:00:00
abstract::There was a mistake in Prof. Giuseppe Massimo Claudio Rosano's affiliation. ...
journal_title:Heart failure reviews
pub_type: 已发布勘误
doi:10.1007/s10741-020-10000-w
更新日期:2020-09-01 00:00:00
abstract::According to previous epidemiological studies, we can reduce the thickness of epicardial fat and improve cardiovascular risk factors through exercise, and the changes may depend on the form of exercise. We systemically reviewed published studies that evaluated exercise intervention on epicardial adipose tissue (EAT) l...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09965-5
更新日期:2020-05-16 00:00:00
abstract::The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are t...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-018-9747-3
更新日期:2019-03-01 00:00:00
abstract::It is well established that cardiac remodeling plays a pivotal role in the development of heart failure, a leading cause of death worldwide. Meanwhile, sympathetic hyperactivity is an important factor in inducing cardiac remodeling. Therefore, an in-depth understanding of beta-adrenoceptor signaling pathways would hel...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-013-9417-4
更新日期:2014-11-01 00:00:00
abstract::Although several risk factors including hypertension, cardiac hypertrophy, coronary artery disease, and diabetes are known to result in heart failure, elderly subjects are more susceptible to myocardial infarction and more likely to develop heart failure. This article is intended to discuss that cardiac dysfunction in...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-011-9278-7
更新日期:2012-09-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, with co-morbidities contributing to the overall severity and mortality of the disease. The incidence and prevalence of cardiovascular disease among COPD patients are high. Both disorders often co-exist, mainly due to smoking, but they al...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9646-z
更新日期:2017-11-01 00:00:00
abstract::Despite therapeutic advances, patients with worsening heart failure (HF) requiring hospitalization have unacceptably high post-discharge mortality and re-admission rates soon after discharge. Evidence suggests a hypercoagulable state is present in patients with HF. Although thromboembolism as a direct consequence of H...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9343-x
更新日期:2013-11-01 00:00:00
abstract::Functional capacity represents an important predictor for cardiovascular and all-cause mortality in patients with diabetes mellitus (DM). Impaired cardiopulmonary fitness is frequently seen in DM patients, and it might partly explain morbidity and mortality in these patients. There are several potential reasons that c...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-10015-3
更新日期:2020-08-15 00:00:00
abstract::There is little doubt that the discovery of ischemic preconditioning (PC) has been one of the fundamental milestones in the field of ischemic biology in the past 20 years. The purpose of this article is to review the pathophysiology and molecular basis of the late phase of myocardial PC. The exploitation of late PC fo...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9031-4
更新日期:2007-12-01 00:00:00
abstract::Heart failure (HF) is a chronic, systemic disorder that presents a serious and growing public health problem due to its high prevalence, mortality, and cost of care. Due to the aging of the population and medical advances that prolong the life of HF patients, more effective, widespread strategies for improved HF manag...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09781-6
更新日期:2019-07-01 00:00:00
abstract::Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-010-9172-8
更新日期:2010-11-01 00:00:00
abstract::This collection of papers covers developments in a rapidly growing area, sarcomeric proteins in hypertrophied and failing myocardium. Advances in our understanding of the biochemistry and biophysics of crossbridge cycling, contributions of thick versus thin filament and the emerging role of titin, the importance and m...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-005-5247-3
更新日期:2005-09-01 00:00:00
abstract::End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9298-y
更新日期:2012-09-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) is a common debilitating condition with limited therapeutic options besides heart transplantation or palliation. It is characterized by maladaptive remodeling of cardiomyocytes, extracellular collagen matrix (ECCM) and left ventricular (LV) geometry which contributes to further dysfunction...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9300-8
更新日期:2012-09-01 00:00:00
abstract::Congestive heart failure is most often caused by scar from coronary occlusion. The transition from occluded vessel to scar to dilation results in a remodeled ventricle that changes shape from ellipse to sphere. This shape change following an index event is called remodeling and a surgical approach for restoration (bri...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-005-6801-8
更新日期:2004-10-01 00:00:00