The management of conditioned nutritional requirements in heart failure.

Abstract:

:Patients suffering from congestive heart failure exhibit impaired myocardial energy production, myocyte calcium overload and increased oxidative stress. Nutritional factors known to be important for myocardial energy production, calcium homeostasis and the reduction of oxidative stress, such as thiamine, riboflavin, pyridoxine, L-carnitine, coenzyme Q10, creatine and taurine are reduced in this patient population. Furthermore, deficiencies of taurine, carnitine, and thiamine are established primary causes of dilated cardiomyopathy. Studies in animals and limited trials in humans have shown that dietary replacement of some of these compounds in heart failure can significantly restore depleted levels and may result in improvement in myocardial structure and function as well as exercise capacity. Larger scale studies examining micronutrient depletion in heart failure patients, and the benefits of dietary replacement need to be performed. At the present time, it is our belief that these conditioned nutritional requirements, if unsatisfied, contribute to myocyte dysfunction and loss; thus, restoration of nutritional deficiencies should be part of the overall therapeutic strategy for patients with congestive heart failure.

journal_name

Heart Fail Rev

journal_title

Heart failure reviews

authors

Allard ML,Jeejeebhoy KN,Sole MJ

doi

10.1007/s10741-006-9195-3

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

75-82

issue

1

eissn

1382-4147

issn

1573-7322

journal_volume

11

pub_type

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