Abstract:
:Treatment of patients with heart failure with reduced ejection fraction (HFrEF) with currently available therapies reduces morbidity and mortality. However, implementation of these therapies is a problem with only few patients achieving guideline-recommended maximal doses of therapy. In an effort to improve guideline adherence and uptitration, several trials have investigated a biomarker-guided strategy (using natriuretic peptide targets in specific), but although conceptually promising, these trials failed to show a consistent beneficial effect on outcomes. In this review, we discuss different methodological issues that may explain the failure of these trials and offer potential solutions. Moreover, alternative approaches to increase heart failure guideline adherence are evaluated.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Stienen S,Bhatt A,Ferreira JP,Vaduganathan M,Januzzi J,Adams K,Tardif JC,Rossignol P,Zannad Fdoi
10.1007/s10741-020-10004-6subject
Has Abstractpub_date
2021-01-01 00:00:00pages
11-21issue
1eissn
1382-4147issn
1573-7322pii
10.1007/s10741-020-10004-6journal_volume
26pub_type
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更新日期:2011-11-01 00:00:00
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