Systolic heart failure in the elderly: optimizing medical management.


:The aging population with hypertension and coronary artery disease is rapidly increasing worldwide and develops heart failure (HF). A wide range of pharmacotherapeutic drugs are recommended in the HF management guidelines. For the most part, these recommendations are based on the results of studies in the younger population, and most drugs were not adequately tested in the elderly. However, many changes that occur during the aging process affect the response to several of the recommended therapeutic drugs. Physicians will be increasingly involved in managing the expanding elderly population with HF. It is therefore imperative that they recognize ways to use current pharmacotherapeutic agents and the increasing need for novel agents for optimizing the management of the elderly patient with HF.


Heart Fail Rev


Heart failure reviews


Man JP,Jugdutt BI




Has Abstract


2012-09-01 00:00:00












  • Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes.

    abstract::Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarct...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Pereira RM,Mekary RA,da Cruz Rodrigues KC,Anaruma CP,Ropelle ER,da Silva ASR,Cintra DE,Pauli JR,de Moura LP

    更新日期:2018-01-01 00:00:00

  • Classical inotropes and new cardiac enhancers.

    abstract::Acute heat failure syndromes are a heterogenous group of conditions. Chronic heart failure exacerbations represent the vast majority of cases. Pathophysiologic mechanisms, such as hypotension with peripheral tissue hypoperfusion, renal function impairment and myocardial ischemia and injury, adversely affect patients' ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Parissis JT,Farmakis D,Nieminen M

    更新日期:2007-06-01 00:00:00

  • The therapeutic effect of natriuretic peptides in heart failure; differential regulation of endothelial and inducible nitric oxide synthases.

    abstract::The abnormal regulation of nitric oxide synthase activity represents an underlying feature of heart failure. Increased peripheral vascular resistance, and decreased renal function may be in part related to impaired endothelium-dependent nitric oxide (NO) synthesis. Paradoxically, the chronic production of NO by induci...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Calderone A

    更新日期:2003-01-01 00:00:00

  • The management of conditioned nutritional requirements in heart failure.

    abstract::Patients suffering from congestive heart failure exhibit impaired myocardial energy production, myocyte calcium overload and increased oxidative stress. Nutritional factors known to be important for myocardial energy production, calcium homeostasis and the reduction of oxidative stress, such as thiamine, riboflavin, p...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Allard ML,Jeejeebhoy KN,Sole MJ

    更新日期:2006-03-01 00:00:00

  • Biomarkers of inflammation in heart failure.

    abstract::Heart failure (HF) is characterized by the elaboration of a portfolio of pro-inflammatory cytokines and inflammatory mediators that are considered to contribute to disease progression by virtue of the deleterious effects that these molecules exert on the heart and circulation. Recent studies have suggested that these ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Bozkurt B,Mann DL,Deswal A

    更新日期:2010-07-01 00:00:00

  • Sarcomeric proteins in hypertrophied and failing myocardium: an overview.

    abstract::This collection of papers covers developments in a rapidly growing area, sarcomeric proteins in hypertrophied and failing myocardium. Advances in our understanding of the biochemistry and biophysics of crossbridge cycling, contributions of thick versus thin filament and the emerging role of titin, the importance and m...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: LeWinter MM,VanBuren P

    更新日期:2005-09-01 00:00:00

  • Sodium glucose cotransporter 2 inhibitors: mechanisms of action in heart failure.

    abstract::Diabetes is a key independent risk factor in the development of heart failure (HF) and a strong, adverse prognostic factor in HF patients. HF remains the primary cause of hospitalisation for diabetics and, as previous studies have shown, when HF occurs in these patients, intensive glycaemic control does not directly i...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Dutka M,Bobiński R,Ulman-Włodarz I,Hajduga M,Bujok J,Pająk C,Ćwiertnia M

    更新日期:2020-11-04 00:00:00

  • Anti-fibrotic effects of curcumin and some of its analogues in the heart.

    abstract::Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, which produce high amounts of extracellular matrix (ECM) proteins leadi...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Gorabi AM,Hajighasemi S,Kiaie N,Rosano GMC,Sathyapalan T,Al-Rasadi K,Sahebkar A

    更新日期:2020-09-01 00:00:00

  • Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients.

    abstract::Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Ruggeri C,Gioffré S,Achilli F,Colombo GI,D'Alessandra Y

    更新日期:2018-01-01 00:00:00

  • Bias in natriuretic peptide-guided heart failure trials: time to improve guideline adherence using alternative approaches.

    abstract::Treatment of patients with heart failure with reduced ejection fraction (HFrEF) with currently available therapies reduces morbidity and mortality. However, implementation of these therapies is a problem with only few patients achieving guideline-recommended maximal doses of therapy. In an effort to improve guideline ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Stienen S,Bhatt A,Ferreira JP,Vaduganathan M,Januzzi J,Adams K,Tardif JC,Rossignol P,Zannad F

    更新日期:2021-01-01 00:00:00

  • Diastolic heart failure: a confusing concept.

    abstract::Descriptions of the pathophysiology of heart failure have gone through a substantial evolution in the last 50 years. It is now recognised that heart failure can occur in the presence and also in the absence of a reduction in left ventricular function. In the former situation, this classically has been described to lea...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Dorhout Mees EJ

    更新日期:2013-07-01 00:00:00

  • Interpretation of B-type natriuretic peptide in cardiac disease and other comorbid conditions.

    abstract::B-Type natriuretic peptide (BNP) is elevated in states of increased ventricular wall stress. BNP is most commonly used to rule out congestive heart failure (CHF) in dyspneic patients. BNP levels are influenced by age, gender and, to a surprisingly large extent, by body mass index (BMI). In addition, it can be elevated...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Burke MA,Cotts WG

    更新日期:2007-03-01 00:00:00

  • Prognostic significance of T1 mapping parameters in heart failure with preserved ejection fraction: a systematic review.

    abstract::Heart failure with preserved ejection fraction (HFpEF) accounts for almost one-half of all heart failure (HF) patients and continues to increase in prevalence. While mortality with heart failure with reduced ejection fraction (HFrEF) has decreased over the past few decades with use of evidence-based HFrEF therapy, mor...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Moustafa A,Khan MS,Alsamman MA,Jamal F,Atalay MK

    更新日期:2020-05-13 00:00:00

  • Diagnostic value of echocardiographic markers for diastolic dysfunction and heart failure with preserved ejection fraction.

    abstract::This study aimed to evaluate the diagnostic performance of echocardiographic markers of heart failure with preserved ejection fraction (HFpEF) and left ventricular diastolic dysfunction (LVDD) in comparison with the gold standard of cardiac catheterization. Diagnosing HFpEF is challenging, as symptoms are non-specific...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Dal Canto E,Remmelzwaal S,van Ballegooijen AJ,Handoko ML,Heymans S,van Empel V,Paulus WJ,Nijpels G,Elders P,Beulens JW

    更新日期:2020-06-02 00:00:00

  • High-density lipoprotein-mediated cardioprotection in heart failure.

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    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Jackson AO,Meng J,Tang H,Yin K

    更新日期:2020-01-27 00:00:00

  • Definition, epidemiology and registries of pulmonary hypertension.

    abstract::Pulmonary arterial hypertension (PAH) is a subcategory of pulmonary hypertension (PH) that comprises a group of disorders with similar pulmonary vascular pathology. Though PH is common, the estimated incidence of IPAH is 1-3 cases per million, making it a rare disease. The hemodynamic definition of PAH is a mean pulmo...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Awdish R,Cajigas H

    更新日期:2016-05-01 00:00:00

  • Infarct size reduction and attenuation of global left ventricular remodeling with the CorCap cardiac support device following acute myocardial infarction in sheep.

    abstract:BACKGROUND:Whether mechanical restraint of the left ventricle (LV) can influence remodeling following myocardial infarction (MI) remains poorly understood. The following discussion details three studies examining the effects of surgically placing a cardiac support device (CSD) over the entire epicardial surface, on inf...

    journal_title:Heart failure reviews

    pub_type: 杂志文章


    authors: Blom AS,Pilla JJ,Gorman RC 3rd,Gorman JH,Mukherjee R,Spinale FG,Acker MA

    更新日期:2005-06-01 00:00:00

  • Age-associated changes in cardiovascular structure and function: a fertile milieu for future disease.

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    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Fleg JL,Strait J

    更新日期:2012-09-01 00:00:00

  • The heart failure burden of type 2 diabetes mellitus-a review of pathophysiology and interventions.

    abstract::Diabetes and heart failure (HF) are both global epidemics with tremendous costs on society with increased rates of HF hospitalizations and worsened prognosis when co-existing, making it a significant "deadly duo." The evidence for pharmacological treatment of HF in patients with type 2 diabetes mellitus (T2DM) stems t...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Ofstad AP,Atar D,Gullestad L,Langslet G,Johansen OE

    更新日期:2018-05-01 00:00:00

  • Cor pulmonale: the role of traditional and advanced echocardiography in the acute and chronic settings.

    abstract::Cor pulmonale is the condition in which the right ventricle undergoes morphological and/or functional changes due to diseases that affect the lungs, the pulmonary circulation, or the breathing process. Depending on the speed of onset of the pathological condition and subsequent effects on the right ventricle, it is po...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Mandoli GE,Sciaccaluga C,Bandera F,Cameli P,Esposito R,D'Andrea A,Evola V,Sorrentino R,Malagoli A,Sisti N,Nistor D,Santoro C,Bargagli E,Mondillo S,Galderisi M,Cameli M,Working group of Echocardiography of Italian Society

    更新日期:2020-08-29 00:00:00

  • Hyperuricemia: a novel old disorder-relationship and potential mechanisms in heart failure.

    abstract::Uric acid, the metabolic mediator of gout and urate renal stones, is associated with increased cardiovascular risk burden. Hyperuricemia is an old emerging metabolic disorder, and interaction among uric acid and cardiovascular diseases has been clearly described. Several illness including hypertension, myocardial infa...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Borghi C,Palazzuoli A,Landolfo M,Cosentino E

    更新日期:2020-01-01 00:00:00

  • Effect of exercise on epicardial adipose tissue in adults: a systematic review and meta-analyses.

    abstract::According to previous epidemiological studies, we can reduce the thickness of epicardial fat and improve cardiovascular risk factors through exercise, and the changes may depend on the form of exercise. We systemically reviewed published studies that evaluated exercise intervention on epicardial adipose tissue (EAT) l...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Colonetti T,Grande AJ,Amaral MC,Colonetti L,Uggioni ML,da Rosa MI,Hernandez AV,Tse G,Liu T,Nerlekar N,Biondi-Zoccai G,Neto MG,Durães AR,Pontes-Neto O,Resende ES,Roever L

    更新日期:2020-05-16 00:00:00

  • Stem cells in the diabetic infarcted heart.

    abstract::Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Glass CE,Singal PK,Singla DK

    更新日期:2010-11-01 00:00:00

  • Therapeutic role of bosentan in hypertension: lessons from the model of perinephritic hypertension.

    abstract::Since its discovery in 1988, there has been increasing evidence that endothelin-1 (ET-1) plays an important role in the pathophysiology of hypertension and its related end-organ damages. First studies, using ET-1 administration in animals or in humans suspected this role by demonstrating the hypertensive properties of...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Donckier JE

    更新日期:2001-12-01 00:00:00

  • RV diastolic dysfunction: time to re-evaluate its importance in heart failure.

    abstract::Right ventricular (RV) diastolic dysfunction was first reported as an indicator for the assessment of ventricular dysfunction in heart failure a little over two decades ago. However, the underlying mechanisms and precise role of RV diastolic dysfunction in heart failure remain poorly described. Complexities in the str...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Axell RG,Hoole SP,Hampton-Till J,White PA

    更新日期:2015-05-01 00:00:00

  • Novel percutaneous interventional therapies in heart failure with preserved ejection fraction: an integrative review.

    abstract::Heart failure with preserved ejection fraction (HFpEF) is a common disorder generating high mortality and important morbidity prevalence, with a very limited medical treatment available. Studies have shown that the pathophysiological hallmark of this condition is an elevated left intra-atrial pressure (LAP), exertiona...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Burlacu A,Simion P,Nistor I,Covic A,Tinica G

    更新日期:2019-09-01 00:00:00

  • Strategies for pacemaker programming in acute heart failure.

    abstract::In the past decade, cardiac pacing devices (either permanent pacemakers or Implanted Cardioverter Defibrillators) have become increasingly common in patients with heart failure. The manner in which the device is programmed to pace the heart can have significant implications on cardiac hemodynamics, both positive and n...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Lahiri MK,Mao JT,Schuger CD

    更新日期:2011-09-01 00:00:00

  • Cardiotoxicity in HER2-positive breast cancer patients.

    abstract::Due to the recent advances in diagnosis and management of patients with HER2-positive breast cancer, especially through novel HER2-targeted agents, cardiotoxicity becomes an emerging problem. Although chemotherapy significantly increases survival, the risk of cardiovascular disease development is high and still undere...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Gonciar D,Mocan L,Zlibut A,Mocan T,Agoston-Coldea L

    更新日期:2021-01-06 00:00:00

  • Aerobic exercise effect on prognostic markers for systolic heart failure patients: a systematic review and meta-analysis.

    abstract::From previous systematic reviews and meta-analyses, there is consensus about the positive effect of exercise training on exercise capacity for systolic heart failure (HF); however, the effect on actual prognostic markers such as NTproBNP and minute ventilation/carbon dioxide production (VE/VCO2) slope has not been eva...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Cipriano G Jr,Cipriano VT,da Silva VZ,Cipriano GF,Chiappa GR,de Lima AC,Cahalin LP,Arena R

    更新日期:2014-09-01 00:00:00

  • Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome.

    abstract::The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审


    authors: Willemsen S,Hartog JW,Heiner-Fokkema MR,van Veldhuisen DJ,Voors AA

    更新日期:2012-03-01 00:00:00