Hyperuricemia: a novel old disorder-relationship and potential mechanisms in heart failure.

abstract：:Pulmonary arterial hypertension (PAH) is a subcategory of pulmonary hypertension (PH) that comprises a group of disorders with similar pulmonary vascular pathology. Though PH is common, the estimated incidence of IPAH is 1-3 cases per million, making it a rare disease. The hemodynamic definition of PAH is a mean pulmo...

journal_title：Heart failure reviews

authors： Awdish R,Cajigas H

更新日期：2016-05-01 00:00:00

abstract：:Cardiac fibrosis is associated with non-ischemic dilated cardiomyopathy, increasing its morbidity and mortality. Cardiac fibroblast is the keystone of fibrogenesis, being activated by numerous cellular and humoral factors. Macrophages, CD4+ and CD8+ T cells, mast cells, and endothelial cells stimulate fibrogenesis dir...

journal_title：Heart failure reviews

authors： Cojan-Minzat BO,Zlibut A,Agoston-Coldea L

更新日期：2020-03-13 00:00:00

abstract：:Acute heat failure syndromes are a heterogenous group of conditions. Chronic heart failure exacerbations represent the vast majority of cases. Pathophysiologic mechanisms, such as hypotension with peripheral tissue hypoperfusion, renal function impairment and myocardial ischemia and injury, adversely affect patients' ...

journal_title：Heart failure reviews

authors： Parissis JT,Farmakis D,Nieminen M

更新日期：2007-06-01 00:00:00

abstract：:End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible...

journal_title：Heart failure reviews

authors： Butler CR,Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:In the United States and Europe, approximately 90% of heart failure hospitalizations are due to symptoms and signs of sodium and fluid excess. Congestion is associated with heart failure progression. Venous congestion, rather than a reduced cardiac output, may be the primary hemodynamic factor driving worsening renal ...

journal_title：Heart failure reviews

authors： Costanzo MR,Jessup M

更新日期：2012-03-01 00:00:00

abstract：:Rheumatic heart disease (RHD) is a major cause of cardiovascular morbidity and mortality in low- and middle-income countries, where living conditions promote spread of group A β-haemolytic streptococcus. Autoimmune reactions due to molecular mimicry of bacterial epitopes by host proteins cause acute rheumatic fever (A...

journal_title：Heart failure reviews

authors： Lumngwena EN,Skatulla S,Blackburn JM,Ntusi NAB

更新日期：2020-07-11 00:00:00

abstract：:In this paper, two different aspects of the relationship between chronic kidney disease and sudden cardiac death (SCD) have been reviewed. In end-stage renal disease patients, SCD risk is increased, and among patients implanted with a cardioverter defibrillator (ICD), dialysed ones carry a superior relative risk compa...

journal_title：Heart failure reviews

authors： Padeletti L,Innocenti L,Paoletti Perini A,Gronda E

更新日期：2011-11-01 00:00:00

abstract：:Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, which produce high amounts of extracellular matrix (ECM) proteins leadi...

journal_title：Heart failure reviews

authors： Gorabi AM,Hajighasemi S,Kiaie N,Rosano GMC,Sathyapalan T,Al-Rasadi K,Sahebkar A

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Transient left ventricular apical ballooning syndrome also called Tako-Tsubo cardiomyopathy is defined as a syndrome consisting of stress induced apical ballooning of the left ventricle and normal coronary arteries. The majority of the published reports are case reports or case series with a small number of ...

journal_title：Heart failure reviews

authors： Donohue D,Movahed MR

更新日期：2005-12-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is due to severe acute respiratory syndrome coronavirus (SARS-CoV)-2 which binds and enters the host cells through the angiotensin-converting enzyme (ACE)2. While the potential for benefit with the use of renin-angiotensin-aldosterone system inhibitors (RAASi) and the risks from sto...

journal_title：Heart failure reviews

authors： Triposkiadis F,Starling RC,Xanthopoulos A,Butler J,Boudoulas H

更新日期：2020-09-01 00:00:00

abstract：:The pathophysiology of heart failure (HF) is characterized by an abnormal activation of neurohumoral systems, including the sympathetic nervous and the renin-angiotensin-aldosterone systems, which have long-term deleterious effects on the disease progression. Perpetuation of this neurohumoral activation is partially d...

journal_title：Heart failure reviews

authors： Sousa-Pinto B,Ferreira-Pinto MJ,Santos M,Leite-Moreira AF

更新日期：2014-11-01 00:00:00

abstract：:There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially im...

journal_title：Heart failure reviews

authors： Mikhailov AT,Torrado M

更新日期：2016-11-01 00:00:00

abstract：:Acute heart failure syndromes (AHFS) are associated with the rapid onset of heart failure (HF) signs and symptoms. Hospitalizations for AHFS continue to rise and are associated with significant mortality and morbidity. Several pharmacological agents are currently approved for the treatment of AHFS, but their use is as...

journal_title：Heart failure reviews

authors： Khan H,Metra M,Blair JE,Vogel M,Harinstein ME,Filippatos GS,Sabbah HN,Porchet H,Valentini G,Gheorghiade M

更新日期：2009-12-01 00:00:00

abstract：:Diabetes is a global epidemic and a leading cause of death with more than 422 million patients worldwide out of whom around 392 million alone suffer from type 2 diabetes (T2D). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel and effective drugs in managing glycemia of T2D patients. These inhibitors gained...

journal_title：Heart failure reviews

authors： Kaplan A,Abidi E,El-Yazbi A,Eid A,Booz GW,Zouein FA

更新日期：2018-05-01 00:00:00

abstract：:Significant growth in the elderly population (age ≥ 65 years) with heart failure (HF) has taken place in developed countries and is occurring in most developing countries. Projections from population studies in the United States, Europe and other developed countries suggest that this trend will very likely continue an...

journal_title：Heart failure reviews

authors： Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Functional capacity represents an important predictor for cardiovascular and all-cause mortality in patients with diabetes mellitus (DM). Impaired cardiopulmonary fitness is frequently seen in DM patients, and it might partly explain morbidity and mortality in these patients. There are several potential reasons that c...

journal_title：Heart failure reviews

authors： Tadic M,Grassi G,Cuspidi C

更新日期：2020-08-15 00:00:00

abstract：:Although mineralocorticoid antagonists (MRAs) have been proposed as effective fourth-line blood pressure (BP) lowering agents in resistant hypertension, this effect in heart failure is undetermined. In this synthesis of heart failure randomized controlled trials (RCTs), we evaluated the extent of BP lowering following...

journal_title：Heart failure reviews

authors： Bazoukis G,Thomopoulos C,Tse G,Tsioufis C

更新日期：2018-07-01 00:00:00

abstract：:Nitric oxide degradation linked to endothelial dysfunction plays a central role in cardiovascular diseases. Superoxide producing enzymes such as NADPH oxidase and xanthine oxidase are responsible for NO degradation as they generate a variety of reactive oxygen species (ROS). Moreover, superoxide is rapidly degraded by...

journal_title：Heart failure reviews

authors： de Gasparo M

更新日期：2002-10-01 00:00:00

abstract：:Right ventricular (RV) diastolic dysfunction was first reported as an indicator for the assessment of ventricular dysfunction in heart failure a little over two decades ago. However, the underlying mechanisms and precise role of RV diastolic dysfunction in heart failure remain poorly described. Complexities in the str...

journal_title：Heart failure reviews

authors： Axell RG,Hoole SP,Hampton-Till J,White PA

更新日期：2015-05-01 00:00:00

abstract：:Although several risk factors including hypertension, cardiac hypertrophy, coronary artery disease, and diabetes are known to result in heart failure, elderly subjects are more susceptible to myocardial infarction and more likely to develop heart failure. This article is intended to discuss that cardiac dysfunction in...

journal_title：Heart failure reviews

authors： Dhalla NS,Rangi S,Babick AP,Zieroth S,Elimban V

更新日期：2012-09-01 00:00:00

abstract：:The aging population with hypertension and coronary artery disease is rapidly increasing worldwide and develops heart failure (HF). A wide range of pharmacotherapeutic drugs are recommended in the HF management guidelines. For the most part, these recommendations are based on the results of studies in the younger popu...

journal_title：Heart failure reviews

authors： Man JP,Jugdutt BI

更新日期：2012-09-01 00:00:00

abstract：:Patients suffering from congestive heart failure exhibit impaired myocardial energy production, myocyte calcium overload and increased oxidative stress. Nutritional factors known to be important for myocardial energy production, calcium homeostasis and the reduction of oxidative stress, such as thiamine, riboflavin, p...

journal_title：Heart failure reviews

authors： Allard ML,Jeejeebhoy KN,Sole MJ

更新日期：2006-03-01 00:00:00

abstract：:Many factors contribute to the pathophysiology and progression of heart failure (HF), offering the potential for many synergistic therapeutic approaches to its management. For patients, who have systolic HF, prolonged QRS and receiving guideline-indicated pharmacological therapy, cardiac resynchronization therapy (CRT...

journal_title：Heart failure reviews

authors： Buga L

更新日期：2012-11-01 00:00:00

abstract：:Accumulation of macrophages within the artery wall is an eminent feature of atherosclerotic plaques. Macrophages are influenced by various plaque microenvironmental stimuli, such as oxidized lipids, cytokines, and senescent erythrocytes, and thereby polarize into two main phenotypes called proinflammatory M1 and anti-...

journal_title：Heart failure reviews

authors： Momtazi-Borojeni AA,Abdollahi E,Nikfar B,Chaichian S,Ekhlasi-Hundrieser M

更新日期：2019-05-01 00:00:00

abstract：:Previous studies have reported superiority of mechanistic target-of-rapamycin (mTOR) antagonists (mTA) over calcineurin inhibitors (CNI) as part of maintenance immunosuppression (IS) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). MEDLINE and EMBASE were searched through October 20...

journal_title：Heart failure reviews

authors： Ueyama H,Kuno T,Takagi H,Alvarez P,Asleh R,Briasoulis A

更新日期：2020-05-18 00:00:00

abstract：:Cardiopulmonary exercise testing (CPET) is a procedure widely used in daily clinical activity to investigate cardiac and pulmonary disorders. Peak oxygen consumption (VO2 peak) is the most validated and clinically accepted parameter used to report aerobic capacity in healthy individuals and in different clinical setti...

journal_title：Heart failure reviews

authors： Gargiulo P,Olla S,Boiti C,Contini M,Perrone-Filardi P,Agostoni P

更新日期：2014-09-01 00:00:00

abstract：:Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact ro...

journal_title：Heart failure reviews

authors： Kobak KA,Radwańska M,Dzięgała M,Kasztura M,Josiak K,Banasiak W,Ponikowski P,Jankowska EA

更新日期：2019-03-01 00:00:00

abstract：:It is over 4 years since the Prospective Comparison of angiotensin receptor/neprilysin inhibitor (ARNI) with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial was published in New England Journal of Medicine. The PARADIGM-HF trial was the one that contributed to the offici...

journal_title：Heart failure reviews

authors： Książczyk M,Lelonek M

更新日期：2020-05-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia...

journal_title：Heart failure reviews

authors： Khayat R,Patt B,Hayes D Jr

更新日期：2009-09-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a common debilitating condition with limited therapeutic options besides heart transplantation or palliation. It is characterized by maladaptive remodeling of cardiomyocytes, extracellular collagen matrix (ECCM) and left ventricular (LV) geometry which contributes to further dysfunction...

journal_title：Heart failure reviews

authors： Butler CR,Jugdutt BI

更新日期：2012-09-01 00:00:00