Abstract：
BACKGROUND:Transient left ventricular apical ballooning syndrome also called Tako-Tsubo cardiomyopathy is defined as a syndrome consisting of stress induced apical ballooning of the left ventricle and normal coronary arteries. The majority of the published reports are case reports or case series with a small number of patients. The goal of this study was to perform statistical analysis of reported cases and case series in the literature in order to study demographic, clinical characteristics and prognosis of this syndrome. METHOD:A PubMed search of the terms transient left ventricular apical ballooning, Tako-Tsubo, takotsubo, and apical cardiomyopathy was conducted for this study. All reports that contained information about individual patients were included in the statistical analysis. RESULTS:The majority of the patients were women (93.5%). Asians were the largest group (57.2%) followed by Caucasians (40%). The presentations mimics an acute myocardial infarction. The most frequent presenting symptom was chest pain (65.9%) followed by dyspnea (16.2%). ST elevation was the most common ECG abnormality (87.5%). Contrary to most reports, this is not a benign disease with complications occurring in 18.9% and death in 3.2%. The most common complication was shock followed by left ventricular thrombus formation and congestive heart failure. CONCLUSION:Apical ballooning syndrome occurs most commonly in women and is associated with high complication rate. There are significant differences in presenting symptoms between race and gender which warrant further investigation.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Donohue D,Movahed MRdoi
10.1007/s10741-005-8555-8subject
Has Abstractpub_date
2005-12-01 00:00:00pages
311-6issue
4eissn
1382-4147issn
1573-7322journal_volume
10pub_type
杂志文章,meta分析abstract：:Diabetes and heart failure (HF) are both global epidemics with tremendous costs on society with increased rates of HF hospitalizations and worsened prognosis when co-existing, making it a significant "deadly duo." The evidence for pharmacological treatment of HF in patients with type 2 diabetes mellitus (T2DM) stems t...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9685-0
更新日期：2018-05-01 00:00:00
abstract：:The evolving paradigm of heart failure has now been expanded to include the favorable neurohormonal, structural and hemodynamic profile of B-type natriuretic peptide [BNP]. As a marker of left ventricular dysfunction, BNP is a practical tool that facilitates diagnosis, contributes to prognostic evaluations and tracks ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1026107701983
更新日期：2003-10-01 00:00:00
abstract：:Recently, it has been suggested that erythropoietin may be useful in the treatment of cardiovascular disease, particularly heart failure. This may be by improving microvascular blood supply and ventricular function through prevention of apoptosis and angiogenesis. Promising results were seen in animals but the few, li...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9288-5
更新日期：2012-05-01 00:00:00
abstract：:Heart failure (HF) is associated with a high morbidity and mortality in the Western World. Our knowledge of the epidemiology, pathophysiology, and therapy has improved dramatically during the last 20 years. Pharmacological treatment, as it stands today, is a combination of preventive and symptomatic strategies. The ma...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-006-9482-z
更新日期：2006-06-01 00:00:00
abstract：:In the United States and Europe, approximately 90% of heart failure hospitalizations are due to symptoms and signs of sodium and fluid excess. Congestion is associated with heart failure progression. Venous congestion, rather than a reduced cardiac output, may be the primary hemodynamic factor driving worsening renal ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9248-0
更新日期：2012-03-01 00:00:00
abstract：:Heart failure (HF) is a common complication in patients with type 2 diabetes and it is closely associated with high morbidity and mortality rate. The incidence of cardiovascular events in patients with diabetes is related to high levels of glycemia, expressed by increase of HbA1c levels. However, there is little evide...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9669-0
更新日期：2018-05-01 00:00:00
abstract：:Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9172-8
更新日期：2010-11-01 00:00:00
abstract：:Rheumatic heart disease (RHD) is a major cause of cardiovascular morbidity and mortality in low- and middle-income countries, where living conditions promote spread of group A β-haemolytic streptococcus. Autoimmune reactions due to molecular mimicry of bacterial epitopes by host proteins cause acute rheumatic fever (A...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09993-1
更新日期：2020-07-11 00:00:00
abstract：:The discovery of cardiac natriuretic peptides two decades ago has lead to considerable research to investigate their biochemical and physiological properties. Clearly the heart is not just a pump but is also an endocrine organ that together with the kidneys control volume overload. The natriuretic peptides are a group...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1026182912461
更新日期：2003-10-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1022147005110
更新日期：2003-01-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-019-09787-0
更新日期：2019-09-01 00:00:00
abstract：:Treatment of patients with heart failure with reduced ejection fraction (HFrEF) with currently available therapies reduces morbidity and mortality. However, implementation of these therapies is a problem with only few patients achieving guideline-recommended maximal doses of therapy. In an effort to improve guideline ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-10004-6
更新日期：2021-01-01 00:00:00
abstract：:According to previous epidemiological studies, we can reduce the thickness of epicardial fat and improve cardiovascular risk factors through exercise, and the changes may depend on the form of exercise. We systemically reviewed published studies that evaluated exercise intervention on epicardial adipose tissue (EAT) l...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09965-5
更新日期：2020-05-16 00:00:00
abstract：:The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are t...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9747-3
更新日期：2019-03-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9324-0
更新日期：2013-01-01 00:00:00
abstract：:In addition to functional alterations, heart failure has a structural basis as well. This concerns all components of the cardiac myocytes as well as the extracellular space. Proteins of the cardiomyocyte can be subdivided in 5 different categories: 1) Contractile proteins including myosin, actin, tropomyosin and the t...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/A:1009813621103
更新日期：2000-10-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-015-9510-y
更新日期：2016-05-01 00:00:00
abstract：:Although several risk factors including hypertension, cardiac hypertrophy, coronary artery disease, and diabetes are known to result in heart failure, elderly subjects are more susceptible to myocardial infarction and more likely to develop heart failure. This article is intended to discuss that cardiac dysfunction in...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9278-7
更新日期：2012-09-01 00:00:00
abstract：:Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims to highlight the...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-009-9137-y
更新日期：2010-01-01 00:00:00
abstract：:Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact ro...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9738-4
更新日期：2019-03-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9239-1
更新日期：2011-09-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-09764-z
更新日期：2019-05-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9132-8
更新日期：2009-12-01 00:00:00
abstract：:Due to the recent advances in diagnosis and management of patients with HER2-positive breast cancer, especially through novel HER2-targeted agents, cardiotoxicity becomes an emerging problem. Although chemotherapy significantly increases survival, the risk of cardiovascular disease development is high and still undere...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-10072-8
更新日期：2021-01-06 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-015-9475-x
更新日期：2015-07-01 00:00:00
abstract：:Predictive computational modelling in biomedical research offers the potential to integrate diverse data, uncover biological mechanisms that are not easily accessible through experimental methods and expose gaps in knowledge requiring further research. Recent developments in computing and diagnostic technologies have ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-016-9528-9
更新日期：2016-11-01 00:00:00
abstract：:The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in r...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9663-y
更新日期：2018-01-01 00:00:00
abstract：:Recent cardiovascular outcome trials have highlighted the propensity of the antidiabetic agents, SGLT2 inhibitors (SGLT2is or -flozin drugs), to exert positive clinical outcomes in patients with cardiovascular disease at risk for major adverse cardiovascular events (MACEs). Of interest in cardiac diabetology is the ph...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09996-y
更新日期：2020-06-24 00:00:00
abstract：:Ultrafiltration (UF) has emerged as an alternative therapy for acute decompensated heart failure (ADHF) due to its physiological benefits such as improvement in neurohormonal activation. We performed a systematic review and a meta-analysis to evaluate the efficacy, safety, and the impact on outcomes for UF therapy as ...
journal_title：Heart failure reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10741-016-9559-2
更新日期：2016-09-01 00:00:00
abstract：:Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarct...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9654-z
更新日期：2018-01-01 00:00:00
