Sodium glucose cotransporter 2 inhibitors: mechanisms of action in heart failure.

Abstract:

:Diabetes is a key independent risk factor in the development of heart failure (HF) and a strong, adverse prognostic factor in HF patients. HF remains the primary cause of hospitalisation for diabetics and, as previous studies have shown, when HF occurs in these patients, intensive glycaemic control does not directly improve the prognosis. Recent clinical studies assessing a new class of antidiabetic drugs, sodium-glucose cotransporter 2 inhibitors (SGLT2is) showed some unexpected beneficial results. Patients treated with SGLT2is had a significant decrease in both cardiovascular (CV) and all-cause mortality and less hospitalisations due to HF compared to those given a placebo. These significant clinical benefits occurred quickly after the drugs were administered and were not solely due to improved glycaemic control. These groundbreaking clinical trials' results have already changed clinical practice in the management of patients with diabetes at high CV risk. These trials have triggered numerous experimental studies aimed at explaining the mechanisms of action of this unique group of drugs. This article presents the current state of knowledge about the mechanisms of action of SGLT2is developed for the treatment of diabetes and which, thanks to their cardioprotective effects, may, in the future, become a treatment for patients with HF.

journal_name

Heart Fail Rev

journal_title

Heart failure reviews

authors

Dutka M,Bobiński R,Ulman-Włodarz I,Hajduga M,Bujok J,Pająk C,Ćwiertnia M

doi

10.1007/s10741-020-10041-1

subject

Has Abstract

pub_date

2020-11-04 00:00:00

eissn

1382-4147

issn

1573-7322

pii

10.1007/s10741-020-10041-1

pub_type

杂志文章,评审
  • Energy metabolism in the hypertrophied heart.

    abstract::In response to a prolonged pressure- or volume-overload, alterations occur in myocardial fatty acid, glucose, and glycogen metabolism. Oxidation of long chain fatty acids has been found to be reduced in hypertrophied hearts compared to non-hypertrophied hearts. However, this observation depends upon the degree of card...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1023/a:1015380609464

    authors: Sambandam N,Lopaschuk GD,Brownsey RW,Allard MF

    更新日期:2002-04-01 00:00:00

  • The therapeutic effect of natriuretic peptides in heart failure; differential regulation of endothelial and inducible nitric oxide synthases.

    abstract::The abnormal regulation of nitric oxide synthase activity represents an underlying feature of heart failure. Increased peripheral vascular resistance, and decreased renal function may be in part related to impaired endothelium-dependent nitric oxide (NO) synthesis. Paradoxically, the chronic production of NO by induci...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1023/a:1022147005110

    authors: Calderone A

    更新日期:2003-01-01 00:00:00

  • Expanded algorithm for managing patients with acute decompensated heart failure.

    abstract::Heart failure is a complex disease process, the manifestation of various cardiac and noncardiac abnormalities. General treatment approaches for heart failure have remained the same over the past decades despite the advent of novel therapies and monitoring modalities. In the same vein, the readmission rates for heart f...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-018-9697-9

    authors: Njoroge JN,Cheema B,Ambrosy AP,Greene SJ,Collins SP,Vaduganathan M,Mebazaa A,Chioncel O,Butler J,Gheorghiade M

    更新日期:2018-07-01 00:00:00

  • Direct cardiovascular impact of SGLT2 inhibitors: mechanisms and effects.

    abstract::Diabetes is a global epidemic and a leading cause of death with more than 422 million patients worldwide out of whom around 392 million alone suffer from type 2 diabetes (T2D). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel and effective drugs in managing glycemia of T2D patients. These inhibitors gained...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-017-9665-9

    authors: Kaplan A,Abidi E,El-Yazbi A,Eid A,Booz GW,Zouein FA

    更新日期:2018-05-01 00:00:00

  • Hyperuricemia: a novel old disorder-relationship and potential mechanisms in heart failure.

    abstract::Uric acid, the metabolic mediator of gout and urate renal stones, is associated with increased cardiovascular risk burden. Hyperuricemia is an old emerging metabolic disorder, and interaction among uric acid and cardiovascular diseases has been clearly described. Several illness including hypertension, myocardial infa...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-019-09869-z

    authors: Borghi C,Palazzuoli A,Landolfo M,Cosentino E

    更新日期:2020-01-01 00:00:00

  • Patient selection for mechanical circulatory support.

    abstract::Heart failure continues to be associated with high morbidity and mortality. Over the past decade, left ventricular assist devices have been shown to improve the survival and quality of life. However, it is quite clear that very sick patients do not do as well, and it is therefore imperative to select patients at the p...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-012-9316-0

    authors: Gilotra NA,Russell SD

    更新日期:2013-01-01 00:00:00

  • Maintenance immunosuppression in heart transplantation: insights from network meta-analysis of various immunosuppression regimens.

    abstract::Previous studies have reported superiority of mechanistic target-of-rapamycin (mTOR) antagonists (mTA) over calcineurin inhibitors (CNI) as part of maintenance immunosuppression (IS) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). MEDLINE and EMBASE were searched through October 20...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-09967-3

    authors: Ueyama H,Kuno T,Takagi H,Alvarez P,Asleh R,Briasoulis A

    更新日期:2020-05-18 00:00:00

  • In search of a standard when analyzing medication adherence in patients with heart failure using claims data: a systematic review.

    abstract::To determine and address medication non-adherence is important and may improve patient outcomes. Our aim was to perform a systematic review on the operationalization of adherence measures in patients with heart failure using claims data. We searched the MEDLINE, EMBASE, and Cochrane databases. A quality check of the f...

    journal_title:Heart failure reviews

    pub_type: 杂志文章

    doi:10.1007/s10741-017-9656-x

    authors: Krueger K,Griese-Mammen N,Schubert I,Kieble M,Botermann L,Laufs U,Kloft C,Schulz M

    更新日期:2018-01-01 00:00:00

  • How does the heart (not) die? The role of autophagy in cardiomyocyte homeostasis and cell death.

    abstract::Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims to highlight the...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-009-9137-y

    authors: Dhesi P,Tehrani F,Fuess J,Schwarz ER

    更新日期:2010-01-01 00:00:00

  • The late phase of preconditioning and its natural clinical application--gene therapy.

    abstract::There is little doubt that the discovery of ischemic preconditioning (PC) has been one of the fundamental milestones in the field of ischemic biology in the past 20 years. The purpose of this article is to review the pathophysiology and molecular basis of the late phase of myocardial PC. The exploitation of late PC fo...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-007-9031-4

    authors: Bolli R,Li QH,Tang XL,Guo Y,Xuan YT,Rokosh G,Dawn B

    更新日期:2007-12-01 00:00:00

  • β-Adrenergic receptor, an essential target in cardiovascular diseases.

    abstract::β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors known as G protein-coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for the activation of adenylyl cyclase (AC) yielding cyclic AMP (CAMP), and this provides valuable responses, which can affect the cardiac function such as...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-019-09825-x

    authors: Ali DC,Naveed M,Gordon A,Majeed F,Saeed M,Ogbuke MI,Atif M,Zubair HM,Changxing L

    更新日期:2020-03-01 00:00:00

  • Aminopeptidase N in arterial hypertension.

    abstract::Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, i...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-007-9061-y

    authors: Danziger RS

    更新日期:2008-09-01 00:00:00

  • Devices and interventions for the prevention of adverse outcomes of tachycardia on heart failure.

    abstract::Heart failure (HF) is the leading cause of hospitalization in the USA. Despite advances in pharmacologic management, the incidence of HF is on the rise and survivability is persistently reduced. Sympathetic overdrive is implicated in the pathophysiology of HF, particularly HF with reduced ejection fraction (HFrEF). Ta...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-018-9680-5

    authors: Devgun J,Jobanputra YB,Arustamyan M,Chait R,Ghumman W

    更新日期:2018-07-01 00:00:00

  • Effects of apelin on the cardiovascular system.

    abstract::Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms characterized by different numbers of amino acids. The number of amino acids in the active isoforms range from 36 to 12. Apelin-13 and, to a lesser extent, apelin-36 are considered the most active isoforms with the greatest act...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-015-9475-x

    authors: Folino A,Montarolo PG,Samaja M,Rastaldo R

    更新日期:2015-07-01 00:00:00

  • Understanding non-response to cardiac resynchronisation therapy: common problems and potential solutions.

    abstract::Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-018-9734-8

    authors: Sieniewicz BJ,Gould J,Porter B,Sidhu BS,Teall T,Webb J,Carr-White G,Rinaldi CA

    更新日期:2019-01-01 00:00:00

  • Biomarkers in heart failure: a clinical review.

    abstract::The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are freq...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-008-9123-9

    authors: Rocchiccioli JP,McMurray JJ,Dominiczak AF

    更新日期:2010-07-01 00:00:00

  • Cor pulmonale: the role of traditional and advanced echocardiography in the acute and chronic settings.

    abstract::Cor pulmonale is the condition in which the right ventricle undergoes morphological and/or functional changes due to diseases that affect the lungs, the pulmonary circulation, or the breathing process. Depending on the speed of onset of the pathological condition and subsequent effects on the right ventricle, it is po...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-10014-4

    authors: Mandoli GE,Sciaccaluga C,Bandera F,Cameli P,Esposito R,D'Andrea A,Evola V,Sorrentino R,Malagoli A,Sisti N,Nistor D,Santoro C,Bargagli E,Mondillo S,Galderisi M,Cameli M,Working group of Echocardiography of Italian Society

    更新日期:2020-08-29 00:00:00

  • A pathway and network review on beta-adrenoceptor signaling and beta blockers in cardiac remodeling.

    abstract::It is well established that cardiac remodeling plays a pivotal role in the development of heart failure, a leading cause of death worldwide. Meanwhile, sympathetic hyperactivity is an important factor in inducing cardiac remodeling. Therefore, an in-depth understanding of beta-adrenoceptor signaling pathways would hel...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-013-9417-4

    authors: Yang J,Liu Y,Fan X,Li Z,Cheng Y

    更新日期:2014-11-01 00:00:00

  • Cardiorespiratory fitness in patients with type 2 diabetes: A missing piece of the puzzle.

    abstract::Functional capacity represents an important predictor for cardiovascular and all-cause mortality in patients with diabetes mellitus (DM). Impaired cardiopulmonary fitness is frequently seen in DM patients, and it might partly explain morbidity and mortality in these patients. There are several potential reasons that c...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-10015-3

    authors: Tadic M,Grassi G,Cuspidi C

    更新日期:2020-08-15 00:00:00

  • RV diastolic dysfunction: time to re-evaluate its importance in heart failure.

    abstract::Right ventricular (RV) diastolic dysfunction was first reported as an indicator for the assessment of ventricular dysfunction in heart failure a little over two decades ago. However, the underlying mechanisms and precise role of RV diastolic dysfunction in heart failure remain poorly described. Complexities in the str...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-015-9472-0

    authors: Axell RG,Hoole SP,Hampton-Till J,White PA

    更新日期:2015-05-01 00:00:00

  • Beta-blockers in heart failure: are pharmacological differences clinically important?

    abstract::Beta-blockers are not an homogeneous group of agents. Only three beta-blockers, carvedilol, bisoprolol and metoprolol succinate, have had favorable effects on prognosis in controlled clinical trials in the patients with chronic heart failure. However, pharmacological differences exist between them. Metoprolol and biso...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1023/B:HREV.0000046367.99002.a4

    authors: Metra M,Cas LD,di Lenarda A,Poole-Wilson P

    更新日期:2004-04-01 00:00:00

  • Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease.

    abstract::There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially im...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-016-9569-0

    authors: Mikhailov AT,Torrado M

    更新日期:2016-11-01 00:00:00

  • Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients.

    abstract::Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-017-9653-0

    authors: Ruggeri C,Gioffré S,Achilli F,Colombo GI,D'Alessandra Y

    更新日期:2018-01-01 00:00:00

  • Correction to: Angiotensin II and angiotensin 1-7: which is their role in atrial fibrillation?

    abstract::There was a mistake in Prof. Giuseppe Massimo Claudio Rosano's affiliation. ...

    journal_title:Heart failure reviews

    pub_type: 已发布勘误

    doi:10.1007/s10741-020-10000-w

    authors: Mascolo A,Urbanek K,De Angelis A,Sessa M,Scavone C,Berrino L,Rosano GMC,Capuano A,Rossi F

    更新日期:2020-09-01 00:00:00

  • Mechanical circulatory support for elderly heart failure patients.

    abstract::End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-012-9298-y

    authors: Butler CR,Jugdutt BI

    更新日期:2012-09-01 00:00:00

  • Metabolic and structural impairment of skeletal muscle in heart failure.

    abstract::Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-012-9353-8

    authors: Zizola C,Schulze PC

    更新日期:2013-09-01 00:00:00

  • Classical inotropes and new cardiac enhancers.

    abstract::Acute heat failure syndromes are a heterogenous group of conditions. Chronic heart failure exacerbations represent the vast majority of cases. Pathophysiologic mechanisms, such as hypotension with peripheral tissue hypoperfusion, renal function impairment and myocardial ischemia and injury, adversely affect patients' ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-007-9014-5

    authors: Parissis JT,Farmakis D,Nieminen M

    更新日期:2007-06-01 00:00:00

  • Renin-angiotensin-system inhibition in the context of corona virus disease-19: experimental evidence, observational studies, and clinical implications.

    abstract::Coronavirus disease 2019 (COVID-19) is due to severe acute respiratory syndrome coronavirus (SARS-CoV)-2 which binds and enters the host cells through the angiotensin-converting enzyme (ACE)2. While the potential for benefit with the use of renin-angiotensin-aldosterone system inhibitors (RAASi) and the risks from sto...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-10022-4

    authors: Triposkiadis F,Starling RC,Xanthopoulos A,Butler J,Boudoulas H

    更新日期:2020-09-01 00:00:00

  • Structural and functional abnormalities in iron-depleted heart.

    abstract::Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact ro...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-018-9738-4

    authors: Kobak KA,Radwańska M,Dzięgała M,Kasztura M,Josiak K,Banasiak W,Ponikowski P,Jankowska EA

    更新日期:2019-03-01 00:00:00

  • B-type natriuretic peptide: physiologic role and assay characteristics.

    abstract::The discovery of cardiac natriuretic peptides two decades ago has lead to considerable research to investigate their biochemical and physiological properties. Clearly the heart is not just a pump but is also an endocrine organ that together with the kidneys control volume overload. The natriuretic peptides are a group...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1023/a:1026182912461

    authors: Azzazy HM,Christenson RH

    更新日期:2003-10-01 00:00:00