Abstract:
:The hippocampus plays an integral role in certain aspects of cognition. Hippocampal structural plasticity and in particular adult hippocampal neurogenesis can be influenced by several intrinsic and extrinsic factors. Here we review how hormones (i.e., intrinsic modulators) and physical exercise (i.e., an extrinsic modulator) can differentially modulate hippocampal plasticity in general and adult hippocampal neurogenesis in particular. Specifically, we provide an overview of the effects of sex hormones, stress hormones, and metabolic hormones on hippocampal structural plasticity and adult hippocampal neurogenesis. In addition, we also discuss how physical exercise modulates these forms of hippocampal plasticity, giving particular emphasis on how this modulation can be affected by variables such as exercise regime, duration, and intensity. Understanding the neurobiological mechanisms underlying the modulation of hippocampal structural plasticity by intrinsic and extrinsic factors will impact the design of new therapeutic approaches aimed at restoring hippocampal plasticity following brain injury or neurodegeneration.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Triviño-Paredes J,Patten AR,Gil-Mohapel J,Christie BRdoi
10.1016/j.yfrne.2016.03.001subject
Has Abstractpub_date
2016-04-01 00:00:00pages
23-43eissn
0091-3022issn
1095-6808pii
S0091-3022(16)30009-7journal_volume
41pub_type
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