Abstract：
:Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Parent AS,Franssen D,Fudvoye J,Gérard A,Bourguignon JPdoi
10.1016/j.yfrne.2014.12.004subject
Has Abstractpub_date
2015-07-01 00:00:00pages
12-36eissn
0091-3022issn
1095-6808pii
S0091-3022(14)00112-5journal_volume
38pub_type
杂志文章,评审abstract：:A rapidly growing body of evidence reveals that complex networks of communication exist between the neuroendocrine and the immune systems. Essential to the maintenance and function of the immune-endocrine circuitry are an array of chemical mediators produced by cells of the immune and endocrine systems. Cytokines are ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1001
更新日期：1995-01-01 00:00:00
abstract：:In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2006.09.004
更新日期：2006-12-01 00:00:00
abstract：:Neuroscientists are likely to discover new sex differences in the coming years, spurred by the National Institutes of Health initiative to include both sexes in preclinical studies. This review summarizes the current state of knowledge of the cellular and molecular mechanisms underlying sex differences in the mammalia...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2016.01.001
更新日期：2016-01-01 00:00:00
abstract：:The concept is proposed that polypeptide neurotrophic factors contribute to the developmental regulation of ovarian and hypothalamic function in mammals. Nerve growth factor (NGF) and neurotrophin-3, two members of the neurotrophin family, have been identified in the rat ovary and one of its receptors has been localiz...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：:Endocrine organizational and activational influences on cognitive and affective circuits are likely critical to the development of premenstrual dysphoric disorder (PMDD), a sex-specific hormone-dependent mood disorder. An overview of the anatomical and functional neural characterization of this disorder is presented h...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100838
更新日期：2020-04-01 00:00:00
abstract：:Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also i...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2012.06.002
更新日期：2012-08-01 00:00:00
abstract：:The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells. The TME emerged as a key modulator of tumour initiation, progression and invasion, with extensive data available in many cancers, but little is ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100852
更新日期：2020-07-01 00:00:00
abstract：:There is considerable evidence that the central nervous system (CNS) is significantly involved in potassium homeostasis: (a) Potassium-specific receptors located in the liver or hepatic portal circulation initiate a reflex increase in potassium excretion via vagal afferents. This reflex is lost or diminished with hypo...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1993.1001
更新日期：1993-01-01 00:00:00
abstract：:The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：
更新日期：1992-07-01 00:00:00
abstract：:Human models demonstrate that experimental activation of the innate immune system has profound effects on brain activation and behavior, inducing fatigue, worsened mood and pain sensitivity. It has been proposed that inflammation is a mechanism involved in the etiology and maintenance of depression, chronic pain and l...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2018.06.005
更新日期：2018-07-01 00:00:00
abstract：:The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1994.1012
更新日期：1994-12-01 00:00:00
abstract：:Trans-generational epigenetic phenomena, such as contamination with endocrine-disrupting chemicals (EDCs) that decrease fertility and the global methylation status of DNA in the offspring, are of great concern because they may affect health, particularly the health of children. However, of even greater concern is the ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.12.004
更新日期：2008-06-01 00:00:00
abstract：:Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiol...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100768
更新日期：2019-07-01 00:00:00
abstract：:Lipids are essential for cellular functioning considering their role in membrane composition, signaling, and energy metabolism. The brain is the second most abundant organ in terms of lipid concentration and diversity only after adipose tissue. However, in the central system (CNS) lipid dysregulation has been linked t...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2021.100899
更新日期：2021-01-12 00:00:00
abstract：:The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprintin...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2008.02.002
更新日期：2008-06-01 00:00:00
abstract：:Insight into the mechanisms of action of neurotrophic growth factors has been obtained through the identification and characterization of gene products that are regulated or modified at the transcriptional, translational, and/or posttranslational level in response to neurotrophin treatment. VGF (non-acronymic) was ide...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.2000.0199
更新日期：2000-07-01 00:00:00
abstract：:A 37-kDa corticotropin releasing factor (CRF) binding protein (CRF-BP) was purified from human plasma by repeated affinity purification and subsequently sequenced and cloned. The human and rat CRF-BP cDNAs encode proteins of 322 amino acids with one putative signal sequence, one N-glycosylation site, and 10 conserved ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1013
更新日期：1995-10-01 00:00:00
abstract：:Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100815
更新日期：2020-01-01 00:00:00
abstract：:Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,meta分析
doi：10.1016/j.yfrne.2019.100775
更新日期：2019-07-01 00:00:00
abstract：:The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival - are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100766
更新日期：2019-07-01 00:00:00
abstract：:Mounting evidence suggests that--beyond the well-known genomic effects--glucocorticoids affect cell function via non-genomic mechanisms. Such mechanisms operate in many major systems and organs including the cardiovascular, immune, endocrine and nervous systems, smooth and skeletal muscles, liver, and fat cells. Non-g...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.10.004
更新日期：2008-05-01 00:00:00
abstract：:The majority of pituitary adenomas are trophically stable and change relatively little in size over many years. A comparatively small proportion behave more aggressively and come to clinical attention through inappropriate hormone secretion or adverse effects on surrounding structures. True malignant behaviour with me...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/s0091-3022(03)00012-8
更新日期：2003-04-01 00:00:00
abstract：:Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced ac...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2008.03.001
更新日期：2008-06-01 00:00:00
abstract：:Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1996.0013
更新日期：1996-10-01 00:00:00
abstract：:Mental illnesses originate early in life, governed by environmental and genetic factors. Because parents are a dominant source of signals to the developing child, parental signals - beginning with maternal signals in utero - are primary contributors to children's mental health. Existing literature on maternal signals ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.01.002
更新日期：2019-04-01 00:00:00
abstract：:Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in t...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.03.002
更新日期：2010-07-01 00:00:00
abstract：:This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinn...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2018.12.001
更新日期：2019-01-01 00:00:00
abstract：:Exercise is known to have beneficial effects on cognition, mood, and the brain. However, exercise also activates the hypothalamic-pituitary-adrenal axis and increases levels of the glucocorticoid cortisol (CORT). CORT, also known as the "stress hormone," is considered a mediator between chronic stress and depression a...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2016.12.001
更新日期：2017-01-01 00:00:00
abstract：:Most human obesity is inherited as a polygenic trait which is largely refractory to medical therapy because obese individuals avidly defend their elevated body weight set-point. This set-point is mediated by an integrated neural network that controls energy homeostasis. Epidemiological studies suggest that perinatal a...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.02.005
更新日期：2010-07-01 00:00:00
abstract：:Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2017.08.001
更新日期：2017-10-01 00:00:00
