abstract：:Lipids are essential for cellular functioning considering their role in membrane composition, signaling, and energy metabolism. The brain is the second most abundant organ in terms of lipid concentration and diversity only after adipose tissue. However, in the central system (CNS) lipid dysregulation has been linked t...

journal_title：Frontiers in neuroendocrinology

authors： Castellanos DB,Martín-Jiménez CA,Rojas-Rodríguez F,Barreto GE,González J

更新日期：2021-01-12 00:00:00

abstract：:The extraction of cortisol from fingernails represents a recent advancement in the retrospective, long-term assessment of hypothalamic-pituitaryadrenal (HPA) axis activity: Fingernail cortisol has the potential to overcome some of the major disadvantages of established HPA axis markers. However, the introduction of an...

journal_title：Frontiers in neuroendocrinology

authors： Fischer S,Schumacher S,Skoluda N,Strahler J

更新日期：2020-07-01 00:00:00

abstract：:Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for ...

journal_title：Frontiers in neuroendocrinology

authors： Hayes CL,Peters BJ,Foster JA

更新日期：2020-07-01 00:00:00

abstract：:The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells. The TME emerged as a key modulator of tumour initiation, progression and invasion, with extensive data available in many cancers, but little is ...

journal_title：Frontiers in neuroendocrinology

authors： Marques P,Grossman AB,Korbonits M

更新日期：2020-07-01 00:00:00

abstract：:Endocrine organizational and activational influences on cognitive and affective circuits are likely critical to the development of premenstrual dysphoric disorder (PMDD), a sex-specific hormone-dependent mood disorder. An overview of the anatomical and functional neural characterization of this disorder is presented h...

journal_title：Frontiers in neuroendocrinology

authors： Dubol M,Epperson CN,Lanzenberger R,Sundström-Poromaa I,Comasco E

更新日期：2020-04-01 00:00:00

abstract：:Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex ...

journal_title：Frontiers in neuroendocrinology

authors： Jaggar M,Rea K,Spichak S,Dinan TG,Cryan JF

更新日期：2020-01-01 00:00:00

abstract：:The maternal microbiota is positioned to regulate the development of offspring immunity, metabolism, as well as brain function and behavior. The mechanisms by which maternal microbial signals drive these processes are beginning to be elucidated. In this review, we provide a brief overview on the importance of the micr...

journal_title：Frontiers in neuroendocrinology

authors： Jašarević E,Bale TL

更新日期：2019-10-01 00:00:00

abstract：:Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...

journal_title：Frontiers in neuroendocrinology

authors： Engel S,Laufer S,Miller R,Niemeyer H,Knaevelsrud C,Schumacher S

更新日期：2019-07-01 00:00:00

abstract：:Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiol...

journal_title：Frontiers in neuroendocrinology

authors： Brenhouse HC,Bath KG

更新日期：2019-07-01 00:00:00

abstract：:The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival - are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of ...

journal_title：Frontiers in neuroendocrinology

authors： Swain JE,Ho SS,Fox H,Garry D,Brummelte S

更新日期：2019-07-01 00:00:00

abstract：:Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively. Recent studies suggest that these neuropeptides may also signal via each other's receptors. The extent to which such cross-system signali...

journal_title：Frontiers in neuroendocrinology

authors： Smith CJW,DiBenedictis BT,Veenema AH

更新日期：2019-04-01 00:00:00

abstract：:Mental illnesses originate early in life, governed by environmental and genetic factors. Because parents are a dominant source of signals to the developing child, parental signals - beginning with maternal signals in utero - are primary contributors to children's mental health. Existing literature on maternal signals ...

journal_title：Frontiers in neuroendocrinology

authors： Glynn LM,Baram TZ

更新日期：2019-04-01 00:00:00

abstract：:This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinn...

journal_title：Frontiers in neuroendocrinology

authors： Payne JL,Maguire J

更新日期：2019-01-01 00:00:00

abstract：:Parental care is found widely across animal taxa and is manifest in a range of behaviours from basic provisioning in cockroaches to highly complex behaviours seen in mammals. The evolution of parental care is viewed as the outcome of an evolutionary cost/benefit trade-off between investing in current and future offspr...

journal_title：Frontiers in neuroendocrinology

authors： Potter HG,Ashbrook DG,Hager R

更新日期：2019-01-01 00:00:00

abstract：:Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribu...

journal_title：Frontiers in neuroendocrinology

authors： Rainville JR,Tsyglakova M,Hodes GE

更新日期：2018-07-01 00:00:00

abstract：:Human models demonstrate that experimental activation of the innate immune system has profound effects on brain activation and behavior, inducing fatigue, worsened mood and pain sensitivity. It has been proposed that inflammation is a mechanism involved in the etiology and maintenance of depression, chronic pain and l...

journal_title：Frontiers in neuroendocrinology

authors： Lasselin J,Lekander M,Axelsson J,Karshikoff B

更新日期：2018-07-01 00:00:00

abstract：:As adolescents transition from childhood to adulthood, many physiological and neurobehavioral changes occur. Shifts in neuroendocrine function are one such change, including the hormonal systems that respond to stressors. This review will focus on these hormonal changes, with a particular emphasis on the pubertal and ...

journal_title：Frontiers in neuroendocrinology

authors： Romeo RD

更新日期：2018-04-01 00:00:00

abstract：:Developmental studies of hormones and behavior often include littermates-rodent siblings that share early-life experiences and genes. Due to between-litter variation (i.e., litter effects), the statistical assumption of independent observations is untenable. In two literatures-natural variation in maternal care and pr...

journal_title：Frontiers in neuroendocrinology

authors： Williams DR,Carlsson R,Bürkner PC

更新日期：2017-10-01 00:00:00

abstract：:Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol ...

journal_title：Frontiers in neuroendocrinology

authors： Rosenfeld CS

更新日期：2017-10-01 00:00:00

abstract：:Exercise is known to have beneficial effects on cognition, mood, and the brain. However, exercise also activates the hypothalamic-pituitary-adrenal axis and increases levels of the glucocorticoid cortisol (CORT). CORT, also known as the "stress hormone," is considered a mediator between chronic stress and depression a...

journal_title：Frontiers in neuroendocrinology

authors： Chen C,Nakagawa S,An Y,Ito K,Kitaichi Y,Kusumi I

更新日期：2017-01-01 00:00:00

abstract：:The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease (PD) have not yet been clarified, and it is controversial whether there is a critical period for neuroprotection. Studies in animal models and clinical and epidemiological studies indicate that estrogens induce dopaminergic neuroprotecti...

journal_title：Frontiers in neuroendocrinology

authors： Labandeira-Garcia JL,Rodriguez-Perez AI,Valenzuela R,Costa-Besada MA,Guerra MJ

更新日期：2016-10-01 00:00:00

abstract：:Psychosocial stress, and within the neuroendocrine reaction to stress specifically the glucocorticoid hormones, are well-characterized inhibitors of neural stem/progenitor cell proliferation in the adult hippocampus, resulting in a marked reduction in the production of new neurons in this brain area relevant for learn...

journal_title：Frontiers in neuroendocrinology

authors： Fitzsimons CP,Herbert J,Schouten M,Meijer OC,Lucassen PJ,Lightman S

更新日期：2016-04-01 00:00:00

abstract：:The hippocampus plays an integral role in certain aspects of cognition. Hippocampal structural plasticity and in particular adult hippocampal neurogenesis can be influenced by several intrinsic and extrinsic factors. Here we review how hormones (i.e., intrinsic modulators) and physical exercise (i.e., an extrinsic mod...

journal_title：Frontiers in neuroendocrinology

authors： Triviño-Paredes J,Patten AR,Gil-Mohapel J,Christie BR

更新日期：2016-04-01 00:00:00

abstract：:Neuroscientists are likely to discover new sex differences in the coming years, spurred by the National Institutes of Health initiative to include both sexes in preclinical studies. This review summarizes the current state of knowledge of the cellular and molecular mechanisms underlying sex differences in the mammalia...

journal_title：Frontiers in neuroendocrinology

authors： Forger NG,Strahan JA,Castillo-Ruiz A

更新日期：2016-01-01 00:00:00

abstract：:Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such dis...

journal_title：Frontiers in neuroendocrinology

authors： Parent AS,Franssen D,Fudvoye J,Gérard A,Bourguignon JP

更新日期：2015-07-01 00:00:00

abstract：:This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It provides the development of our understanding of the neuroendocrine control of puberty since Harris proposed in his 1955 monograph (Harris, 1955) th...

journal_title：Frontiers in neuroendocrinology

authors： Plant TM

更新日期：2015-07-01 00:00:00

abstract：:To cope with variations in the environment, most mammalian species exhibit seasonal cycles in physiology and behaviour. Seasonal plasticity during the lifetime contributes to seasonal physiology. Over the years, our ideas regarding adult brain plasticity and, more specifically, hypothalamic plasticity have greatly evo...

journal_title：Frontiers in neuroendocrinology

authors： Migaud M,Butrille L,Batailler M

更新日期：2015-04-01 00:00:00

abstract：:This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...

journal_title：Frontiers in neuroendocrinology

authors： Olza-Fernández I,Marín Gabriel MA,Gil-Sanchez A,Garcia-Segura LM,Arevalo MA

更新日期：2014-10-01 00:00:00

abstract：:Sex chromosome genes directly influence sex differences in behavior. The discovery of the Sry gene on the Y chromosome (Gubbay et al., 1990; Koopman et al., 1990) substantiated the sex chromosome mechanistic link to sex differences. Moreover, the pronounced connection between X chromosome gene mutations and mental ill...

journal_title：Frontiers in neuroendocrinology

authors： Cox KH,Bonthuis PJ,Rissman EF

更新日期：2014-10-01 00:00:00

abstract：:Attention Deficit Hyperactivity Disorder (ADHD) is a developmental condition characterised by severe inattention, pathological impulsivity and hyperactivity; it is relatively common affecting up to 6% of children, and is associated with a risk of long-term adverse educational and social consequences. Males are conside...

journal_title：Frontiers in neuroendocrinology

authors： Davies W

更新日期：2014-08-01 00:00:00

abstract：:Drug addiction is a chronically relapsing disorder characterized by loss of control over intake and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie Vale and his colleagues of corticotropin-releasing factor (CRF) and the structurally-related urocortins, CRF systems have emerged as ...

journal_title：Frontiers in neuroendocrinology

authors： Zorrilla EP,Logrip ML,Koob GF

更新日期：2014-04-01 00:00:00

abstract：:Alcohol stimulates the hypothalamic-pituitary-adrenal (HPA) axis through brain-based mechanisms in which endogenous corticotropin-releasing factor (CRF) plays a major role. This review first discusses the evidence for this role, as well as the possible importance of intermediates such as vasopressin, nitric oxide and ...

journal_title：Frontiers in neuroendocrinology

authors： Rivier C

更新日期：2014-04-01 00:00:00

abstract：:Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and ...

journal_title：Frontiers in neuroendocrinology

authors： Rivier JE,Rivier CL

更新日期：2014-04-01 00:00:00

abstract：:Organisms living outside the tropics use changes in photoperiod to adapt to seasonal changes in the environment. Several models have contributed to an understanding of this mechanism at the molecular and endocrine levels. Subtropical birds are excellent models for the study of these mechanisms because of their rapid a...

journal_title：Frontiers in neuroendocrinology

authors： Yoshimura T

更新日期：2013-08-01 00:00:00

abstract：:Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also i...

journal_title：Frontiers in neuroendocrinology

authors： O'Kusky J,Ye P

更新日期：2012-08-01 00:00:00

abstract：:Food reward, not hunger, is the main driving force behind eating in the modern obesogenic environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily overconsumed despite the resulting health consequences. Important advances have been made to explain mechanisms underlying excessive co...

journal_title：Frontiers in neuroendocrinology

authors： Alsiö J,Olszewski PK,Levine AS,Schiöth HB

更新日期：2012-04-01 00:00:00

abstract：:Many vertebrates are highly motivated to communicate, suggesting that the consequences of communication may be rewarding. Past studies show that dopamine and opioids in the medial preoptic nucleus (mPOA) and ventral tegmental area (VTA) play distinct roles in motivation and reward. In songbirds, multiple lines of rece...

journal_title：Frontiers in neuroendocrinology

authors： Riters LV

更新日期：2012-04-01 00:00:00

abstract：:Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) is the most common mouse model of MS. Treatments with the sex hormones, estrogens and androgens, are capable of offering disease protection during...

journal_title：Frontiers in neuroendocrinology

authors： Spence RD,Voskuhl RR

更新日期：2012-01-01 00:00:00

abstract：:17β-Estradiol (estradiol or E2) is implicated as a neuroprotective factor in a variety of neurodegenerative disorders. This review focuses on the mechanisms underlying E2 neuroprotection in cerebral ischemia, as well as emerging evidence from basic science and clinical studies, which suggests that there is a "critical...

journal_title：Frontiers in neuroendocrinology

authors： Scott E,Zhang QG,Wang R,Vadlamudi R,Brann D

更新日期：2012-01-01 00:00:00

abstract：:The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup ...

journal_title：Frontiers in neuroendocrinology

authors： Son GH,Chung S,Kim K

更新日期：2011-10-01 00:00:00