Pathophysiological mechanisms implicated in postpartum depression.

Abstract:

:This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinnings. The evidence supporting a role for neuroendocrine changes, neuroinflammation, neurotransmitter alterations, circuit dysfunction, and the involvement of genetics and epigenetics in the pathophysiology of postpartum depression are discussed. This review integrates clinical and preclinical findings and highlights the diversity in the patient population, in which numerous pathophysiological changes may contribute to this disorder. Finally, we attempt to integrate these findings to understand how diverse neurobiological changes may contribute to a common pathological phenotype. This review is meant to serve as a comprehensive resource reviewing the proposed pathophysiological mechanisms underlying postpartum depression.

journal_name

Front Neuroendocrinol

authors

Payne JL,Maguire J

doi

10.1016/j.yfrne.2018.12.001

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

165-180

eissn

0091-3022

issn

1095-6808

pii

S0091-3022(18)30074-8

journal_volume

52

pub_type

杂志文章,评审
  • Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis.

    abstract::Psychosocial stress, and within the neuroendocrine reaction to stress specifically the glucocorticoid hormones, are well-characterized inhibitors of neural stem/progenitor cell proliferation in the adult hippocampus, resulting in a marked reduction in the production of new neurons in this brain area relevant for learn...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2016.05.001

    authors: Fitzsimons CP,Herbert J,Schouten M,Meijer OC,Lucassen PJ,Lightman S

    更新日期:2016-04-01 00:00:00

  • Developmental gene x environment interactions affecting systems regulating energy homeostasis and obesity.

    abstract::Most human obesity is inherited as a polygenic trait which is largely refractory to medical therapy because obese individuals avidly defend their elevated body weight set-point. This set-point is mediated by an integrated neural network that controls energy homeostasis. Epidemiological studies suggest that perinatal a...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2010.02.005

    authors: Levin BE

    更新日期:2010-07-01 00:00:00

  • Assessing viral gene therapy in neuroendocrine models.

    abstract::A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1999.0184

    authors: Geddes BJ,Harding TC,Lightman SL,Uney JB

    更新日期:1999-10-01 00:00:00

  • Mouse model systems to study sex chromosome genes and behavior: relevance to humans.

    abstract::Sex chromosome genes directly influence sex differences in behavior. The discovery of the Sry gene on the Y chromosome (Gubbay et al., 1990; Koopman et al., 1990) substantiated the sex chromosome mechanistic link to sex differences. Moreover, the pronounced connection between X chromosome gene mutations and mental ill...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2013.12.004

    authors: Cox KH,Bonthuis PJ,Rissman EF

    更新日期:2014-10-01 00:00:00

  • Influence of immune signals on the hypothalamic-pituitary axis of the rodent.

    abstract::The immune system and the hypothalamic-pituitary (H-P) axis are functionally connected, so that exposure to antigens elicits a coordinated response which allows the organism to successfully withstand immunologic challenges. An important feature of this bilateral communication is the appearance of proteins released int...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1995.1005

    authors: Rivier C

    更新日期:1995-04-01 00:00:00

  • The song remains the same: coactivators and sex differences in the songbird brain.

    abstract::The majority of songbird species have sexually dimorphic neuronal circuits for song learning and production and these differences are paralleled by sex differences in behavior, with only males singing or singing at a higher rate than females. Therefore songbirds serve as an excellent model for studying the mechanisms ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2010.11.001

    authors: Duncan KA,Carruth LL

    更新日期:2011-01-01 00:00:00

  • Role of the cytokines in the neuroendocrine-immune system axis.

    abstract::A rapidly growing body of evidence reveals that complex networks of communication exist between the neuroendocrine and the immune systems. Essential to the maintenance and function of the immune-endocrine circuitry are an array of chemical mediators produced by cells of the immune and endocrine systems. Cytokines are ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1995.1001

    authors: Spangelo BL,Gorospe WC

    更新日期:1995-01-01 00:00:00

  • Neurodevelopmental effects of insulin-like growth factor signaling.

    abstract::Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also i...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2012.06.002

    authors: O'Kusky J,Ye P

    更新日期:2012-08-01 00:00:00

  • The area postrema and vomiting.

    abstract::The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1994.1012

    authors: Miller AD,Leslie RA

    更新日期:1994-12-01 00:00:00

  • VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance.

    abstract::Insight into the mechanisms of action of neurotrophic growth factors has been obtained through the identification and characterization of gene products that are regulated or modified at the transcriptional, translational, and/or posttranslational level in response to neurotrophin treatment. VGF (non-acronymic) was ide...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.2000.0199

    authors: Salton SR,Ferri GL,Hahm S,Snyder SE,Wilson AJ,Possenti R,Levi A

    更新日期:2000-07-01 00:00:00

  • The EDGE hypothesis: epigenetically directed genetic errors in repeat-containing proteins (RCPs) involved in evolution, neuroendocrine signaling, and cancer.

    abstract::Trans-generational epigenetic phenomena, such as contamination with endocrine-disrupting chemicals (EDCs) that decrease fertility and the global methylation status of DNA in the offspring, are of great concern because they may affect health, particularly the health of children. However, of even greater concern is the ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2007.12.004

    authors: Ruden DM,Jamison DC,Zeeberg BR,Garfinkel MD,Weinstein JN,Rasouli P,Lu X

    更新日期:2008-06-01 00:00:00

  • Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevance.

    abstract::Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2013.10.006

    authors: Rivier JE,Rivier CL

    更新日期:2014-04-01 00:00:00

  • Sex differences in attention Deficit Hyperactivity Disorder: candidate genetic and endocrine mechanisms.

    abstract::Attention Deficit Hyperactivity Disorder (ADHD) is a developmental condition characterised by severe inattention, pathological impulsivity and hyperactivity; it is relatively common affecting up to 6% of children, and is associated with a risk of long-term adverse educational and social consequences. Males are conside...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2014.03.003

    authors: Davies W

    更新日期:2014-08-01 00:00:00

  • Roles of inhibins, activins, and follistatin in the female reproductive system.

    abstract::Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1996.0013

    authors: Knight PG

    更新日期:1996-10-01 00:00:00

  • Deciphering sex differences in the immune system and depression.

    abstract::Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribu...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2017.12.004

    authors: Rainville JR,Tsyglakova M,Hodes GE

    更新日期:2018-07-01 00:00:00

  • Neuroendocrinology of childbirth and mother-child attachment: the basis of an etiopathogenic model of perinatal neurobiological disorders.

    abstract::This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2014.03.007

    authors: Olza-Fernández I,Marín Gabriel MA,Gil-Sanchez A,Garcia-Segura LM,Arevalo MA

    更新日期:2014-10-01 00:00:00

  • Between-litter variation in developmental studies of hormones and behavior: Inflated false positives and diminished power.

    abstract::Developmental studies of hormones and behavior often include littermates-rodent siblings that share early-life experiences and genes. Due to between-litter variation (i.e., litter effects), the statistical assumption of independent observations is untenable. In two literatures-natural variation in maternal care and pr...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2017.08.003

    authors: Williams DR,Carlsson R,Bürkner PC

    更新日期:2017-10-01 00:00:00

  • Demographic, sampling- and assay-related confounders of endogenous oxytocin concentrations: A systematic review and meta-analysis.

    abstract::Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.yfrne.2019.100775

    authors: Engel S,Laufer S,Miller R,Niemeyer H,Knaevelsrud C,Schumacher S

    更新日期:2019-07-01 00:00:00

  • Neuroendocrine control of the onset of puberty.

    abstract::This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It provides the development of our understanding of the neuroendocrine control of puberty since Harris proposed in his 1955 monograph (Harris, 1955) th...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2015.04.002

    authors: Plant TM

    更新日期:2015-07-01 00:00:00

  • Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents.

    abstract::Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such dis...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2014.12.004

    authors: Parent AS,Franssen D,Fudvoye J,Gérard A,Bourguignon JP

    更新日期:2015-07-01 00:00:00

  • Offspring genetic effects on maternal care.

    abstract::Parental care is found widely across animal taxa and is manifest in a range of behaviours from basic provisioning in cockroaches to highly complex behaviours seen in mammals. The evolution of parental care is viewed as the outcome of an evolutionary cost/benefit trade-off between investing in current and future offspr...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2018.12.004

    authors: Potter HG,Ashbrook DG,Hager R

    更新日期:2019-01-01 00:00:00

  • The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels.

    abstract::Exercise is known to have beneficial effects on cognition, mood, and the brain. However, exercise also activates the hypothalamic-pituitary-adrenal axis and increases levels of the glucocorticoid cortisol (CORT). CORT, also known as the "stress hormone," is considered a mediator between chronic stress and depression a...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2016.12.001

    authors: Chen C,Nakagawa S,An Y,Ito K,Kitaichi Y,Kusumi I

    更新日期:2017-01-01 00:00:00

  • Fast glucocorticoid actions on brain: back to the future.

    abstract::Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2005.08.001

    authors: Dallman MF

    更新日期:2005-10-01 00:00:00

  • Corticotropin releasing factor: a key role in the neurobiology of addiction.

    abstract::Drug addiction is a chronically relapsing disorder characterized by loss of control over intake and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie Vale and his colleagues of corticotropin-releasing factor (CRF) and the structurally-related urocortins, CRF systems have emerged as ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2014.01.001

    authors: Zorrilla EP,Logrip ML,Koob GF

    更新日期:2014-04-01 00:00:00

  • Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems.

    abstract::The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprintin...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2008.02.002

    authors: Gore AC

    更新日期:2008-06-01 00:00:00

  • Reflexive testosterone release: a model system for studying the nongenomic effects of testosterone upon male behavior.

    abstract::Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2007.09.001

    authors: Nyby JG

    更新日期:2008-05-01 00:00:00

  • Sex differences in the neural circuit that mediates female sexual receptivity.

    abstract::Female sexual behavior in rodents, typified by the lordosis posture, is hormone-dependent and sex-specific. Ovarian hormones control this behavior via receptors in the hypothalamic ventromedial nucleus (VMH). This review considers the sex differences in the morphology, neurochemistry and neural circuitry of the VMH to...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2011.02.008

    authors: Flanagan-Cato LM

    更新日期:2011-04-01 00:00:00

  • Estrogenic encounters: how interactions between aromatase and the environment modulate aggression.

    abstract::Initial investigations into the mechanistic basis of aggression focused on the role of testosterone (T) and a variety of studies on non-human animals found that elevated T levels promote aggression. However, many correlational studies have not detected a significant association between aggression and peripheral T leve...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2005.11.001

    authors: Trainor BC,Kyomen HH,Marler CA

    更新日期:2006-07-01 00:00:00

  • Estrogen neuroprotection and the critical period hypothesis.

    abstract::17β-Estradiol (estradiol or E2) is implicated as a neuroprotective factor in a variety of neurodegenerative disorders. This review focuses on the mechanisms underlying E2 neuroprotection in cerebral ischemia, as well as emerging evidence from basic science and clinical studies, which suggests that there is a "critical...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2011.10.001

    authors: Scott E,Zhang QG,Wang R,Vadlamudi R,Brann D

    更新日期:2012-01-01 00:00:00

  • Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration.

    abstract::Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) is the most common mouse model of MS. Treatments with the sex hormones, estrogens and androgens, are capable of offering disease protection during...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2011.12.001

    authors: Spence RD,Voskuhl RR

    更新日期:2012-01-01 00:00:00