Abstract：
:Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiological differences can mediate risk and resilience has proven difficult in population based studies. Use of animal models provides a powerful toolset to isolate key variables underlying risk for altered neural and behavioral maturational trajectories. However, a lack of clarity regarding the unique features of differing forms of adversity, lab differences in the implementation and reporting of methods, and the ability compare across labs and types of ELA has led to some confusion. Here, we highlight the diversity of approaches available, current challenges, and a possible ways forward to increase clarity and drive more meaningful and fruitful implementation and comparison of these approaches.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Brenhouse HC,Bath KGdoi
10.1016/j.yfrne.2019.100768subject
Has Abstractpub_date
2019-07-01 00:00:00pages
100768eissn
0091-3022issn
1095-6808pii
S0091-3022(19)30030-5journal_volume
54pub_type
杂志文章,评审abstract：:Identification of novel neurohormones that regulate the reproductive axis is essential for the progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin modulate gonado...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.03.001
更新日期：2010-07-01 00:00:00
abstract：:Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2013.10.006
更新日期：2014-04-01 00:00:00
abstract：:Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.09.001
更新日期：2008-05-01 00:00:00
abstract：:The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：
更新日期：1992-07-01 00:00:00
abstract：:Organisms living outside the tropics use changes in photoperiod to adapt to seasonal changes in the environment. Several models have contributed to an understanding of this mechanism at the molecular and endocrine levels. Subtropical birds are excellent models for the study of these mechanisms because of their rapid a...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2013.04.002
更新日期：2013-08-01 00:00:00
abstract：:Sex chromosome genes directly influence sex differences in behavior. The discovery of the Sry gene on the Y chromosome (Gubbay et al., 1990; Koopman et al., 1990) substantiated the sex chromosome mechanistic link to sex differences. Moreover, the pronounced connection between X chromosome gene mutations and mental ill...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2013.12.004
更新日期：2014-10-01 00:00:00
abstract：:Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such dis...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2014.12.004
更新日期：2015-07-01 00:00:00
abstract：:Attention Deficit Hyperactivity Disorder (ADHD) is a developmental condition characterised by severe inattention, pathological impulsivity and hyperactivity; it is relatively common affecting up to 6% of children, and is associated with a risk of long-term adverse educational and social consequences. Males are conside...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2014.03.003
更新日期：2014-08-01 00:00:00
abstract：:Clinical introduction of octreotide, a long-acting somatostatin analog, has opened a new era in the medical therapy of patients with growth hormone (GH)- and thyroid-stimulating hormone (TSH)-secreting pituitary tumors. Good control of hormonal hypersecretion occurred in most patients, and tumor shrinkage has been obs...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1993.1002
更新日期：1993-01-01 00:00:00
abstract：:Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100849
更新日期：2020-07-01 00:00:00
abstract：:The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.07.003
更新日期：2011-10-01 00:00:00
abstract：:Female sexual behavior in rodents, typified by the lordosis posture, is hormone-dependent and sex-specific. Ovarian hormones control this behavior via receptors in the hypothalamic ventromedial nucleus (VMH). This review considers the sex differences in the morphology, neurochemistry and neural circuitry of the VMH to...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.02.008
更新日期：2011-04-01 00:00:00
abstract：:In addition to its well documented action in female-typical behaviors, progesterone exerts an influence on the brain and behavior of males. This review will discuss the role of progesterone and its receptor in male-typical reproductive behaviors in adulthood and the role of progesterone and its receptor in neural deve...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2006.07.003
更新日期：2006-09-01 00:00:00
abstract：:This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It provides the development of our understanding of the neuroendocrine control of puberty since Harris proposed in his 1955 monograph (Harris, 1955) th...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2015.04.002
更新日期：2015-07-01 00:00:00
abstract：:This review examines recent advances in the study of the behavioral responses to deficits of body water and body sodium that in humans are accompanied by the sensations of thirst and salt appetite. Thirst and salt appetite are satisfied by ingesting water and salty substances. These behavioral responses to losses of b...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1997.0153
更新日期：1997-07-01 00:00:00
abstract：:The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1994.1012
更新日期：1994-12-01 00:00:00
abstract：:Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in t...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.03.002
更新日期：2010-07-01 00:00:00
abstract：:17β-Estradiol (estradiol or E2) is implicated as a neuroprotective factor in a variety of neurodegenerative disorders. This review focuses on the mechanisms underlying E2 neuroprotection in cerebral ischemia, as well as emerging evidence from basic science and clinical studies, which suggests that there is a "critical...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.10.001
更新日期：2012-01-01 00:00:00
abstract：:A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1999.0184
更新日期：1999-10-01 00:00:00
abstract：:The maternal microbiota is positioned to regulate the development of offspring immunity, metabolism, as well as brain function and behavior. The mechanisms by which maternal microbial signals drive these processes are beginning to be elucidated. In this review, we provide a brief overview on the importance of the micr...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100797
更新日期：2019-10-01 00:00:00
abstract：:In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2006.09.004
更新日期：2006-12-01 00:00:00
abstract：:Initial investigations into the mechanistic basis of aggression focused on the role of testosterone (T) and a variety of studies on non-human animals found that elevated T levels promote aggression. However, many correlational studies have not detected a significant association between aggression and peripheral T leve...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2005.11.001
更新日期：2006-07-01 00:00:00
abstract：:Two different approaches have been utilized to study the controlling mechanisms that underlie the generation and entrainment of circadian rhythms in mammals. The use of specific drugs to alter the period and/or the phase of circadian rhythms has provided new insights into both the pathways by which environmental infor...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1007
更新日期：1995-07-01 00:00:00
abstract：:Mounting evidence suggests that--beyond the well-known genomic effects--glucocorticoids affect cell function via non-genomic mechanisms. Such mechanisms operate in many major systems and organs including the cardiovascular, immune, endocrine and nervous systems, smooth and skeletal muscles, liver, and fat cells. Non-g...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.10.004
更新日期：2008-05-01 00:00:00
abstract：:Gene therapy, which entails the use of nucleic acids as drugs, is a new approach to treat disease. Gene therapy has been successfully implemented in several preclinical animal models, including several paradigms of experimental pituitary tumors. In spite of these successes, several critical issues need to be addressed...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/s0091-3022(02)00106-1
更新日期：2003-01-01 00:00:00
abstract：:Most human obesity is inherited as a polygenic trait which is largely refractory to medical therapy because obese individuals avidly defend their elevated body weight set-point. This set-point is mediated by an integrated neural network that controls energy homeostasis. Epidemiological studies suggest that perinatal a...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.02.005
更新日期：2010-07-01 00:00:00
abstract：:This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2014.03.007
更新日期：2014-10-01 00:00:00
abstract：:Endocrine organizational and activational influences on cognitive and affective circuits are likely critical to the development of premenstrual dysphoric disorder (PMDD), a sex-specific hormone-dependent mood disorder. An overview of the anatomical and functional neural characterization of this disorder is presented h...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100838
更新日期：2020-04-01 00:00:00
abstract：:Food reward, not hunger, is the main driving force behind eating in the modern obesogenic environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily overconsumed despite the resulting health consequences. Important advances have been made to explain mechanisms underlying excessive co...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2012.01.002
更新日期：2012-04-01 00:00:00
abstract：:The extraction of cortisol from fingernails represents a recent advancement in the retrospective, long-term assessment of hypothalamic-pituitaryadrenal (HPA) axis activity: Fingernail cortisol has the potential to overcome some of the major disadvantages of established HPA axis markers. However, the introduction of an...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100855
更新日期：2020-07-01 00:00:00
