Sex differences in the neural circuit that mediates female sexual receptivity.

Abstract:

:Female sexual behavior in rodents, typified by the lordosis posture, is hormone-dependent and sex-specific. Ovarian hormones control this behavior via receptors in the hypothalamic ventromedial nucleus (VMH). This review considers the sex differences in the morphology, neurochemistry and neural circuitry of the VMH to gain insights into the mechanisms that control lordosis. The VMH is larger in males compared with females, due to more synaptic connections. Another sex difference is the responsiveness to estradiol, with males exhibiting muted, and in some cases reverse, effects compared with females. The lack of lordosis in males may be explained by differences in synaptic organization or estrogen responsiveness, or both, in the VMH. However, given that damage to other brain regions unmasks lordosis behavior in males, a male-typical VMH is unlikely the main factor that prevents lordosis. In females, key questions remain regarding the mechanisms whereby ovarian hormones modulate VMH function to promote lordosis.

journal_name

Front Neuroendocrinol

authors

Flanagan-Cato LM

doi

10.1016/j.yfrne.2011.02.008

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

124-36

issue

2

eissn

0091-3022

issn

1095-6808

pii

S0091-3022(11)00026-4

journal_volume

32

pub_type

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