Abstract：
:The extraction of cortisol from fingernails represents a recent advancement in the retrospective, long-term assessment of hypothalamic-pituitaryadrenal (HPA) axis activity: Fingernail cortisol has the potential to overcome some of the major disadvantages of established HPA axis markers. However, the introduction of any novel methodology also raises certain caveats. This review provides a comprehensive summary of the current state of research on fingernail cortisol. It identifies a number of strengths of his novel methodology (e.g., its high feasibility), while also pointing out open questions which currently challenge the interpretability of fingernail findings, in particular regarding the time period of cortisol secretion reflected in fingernail samples, as well as regarding potential determinants or confounders of fingernail cortisol (e.g. sociodemographic, lifestyle, or health characteristics). Clarification of these issues in the context of further methodological studies is necessary to validate the use of fingernail cortisol as a retrospective marker of HPA axis activity.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Fischer S,Schumacher S,Skoluda N,Strahler Jdoi
10.1016/j.yfrne.2020.100855subject
Has Abstractpub_date
2020-07-01 00:00:00pages
100855eissn
0091-3022issn
1095-6808pii
S0091-3022(20)30046-7journal_volume
58pub_type
杂志文章,评审abstract：:Most human obesity is inherited as a polygenic trait which is largely refractory to medical therapy because obese individuals avidly defend their elevated body weight set-point. This set-point is mediated by an integrated neural network that controls energy homeostasis. Epidemiological studies suggest that perinatal a...
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