Abstract:
:The majority of songbird species have sexually dimorphic neuronal circuits for song learning and production and these differences are paralleled by sex differences in behavior, with only males singing or singing at a higher rate than females. Therefore songbirds serve as an excellent model for studying the mechanisms that influence the sexually dimorphic development of the brain and behavior. Past research focused on the actions of steroid hormones or their receptors in the development of these sex differences. This review examines the distribution and action of steroid receptor coactivators in the songbird brain; more specifically the actions of RPL7, SRC-1, and CBP on the song control system. Coactivators enhance the transcriptional activity of the nuclear steroid receptors with which they associate, and therefore may play a role in modulating the development of sex differences in the brain and behavior. The actions of these proteins may help elucidate the hormonal mechanisms that underlie song nuclei development and steroid activated singing behavior in adulthood.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Duncan KA,Carruth LLdoi
10.1016/j.yfrne.2010.11.001subject
Has Abstractpub_date
2011-01-01 00:00:00pages
84-94issue
1eissn
0091-3022issn
1095-6808pii
S0091-3022(10)00074-9journal_volume
32pub_type
杂志文章,评审abstract::Developmental studies of hormones and behavior often include littermates-rodent siblings that share early-life experiences and genes. Due to between-litter variation (i.e., litter effects), the statistical assumption of independent observations is untenable. In two literatures-natural variation in maternal care and pr...
journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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abstract::Identification of novel neurohormones that regulate the reproductive axis is essential for the progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin modulate gonado...
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