Abstract：
:Most human obesity is inherited as a polygenic trait which is largely refractory to medical therapy because obese individuals avidly defend their elevated body weight set-point. This set-point is mediated by an integrated neural network that controls energy homeostasis. Epidemiological studies suggest that perinatal and pre-pubertal environmental factors can promote offspring obesity. Rodent studies demonstrate the important interactions between genetic predisposition and environmental factors in promoting obesity. This review covers issues of development and function of neural systems involved in the regulation of energy homeostasis and the roles of leptin and insulin in these processes, the ways in which interventions at various phases from gestation, lactation and pre-pubertal stages of development can favorably and unfavorably alter the development of obesity n offspring. These studies suggest that early identification of obesity-prone humans and of the factors that can prevent them from becoming obese could provide an effective strategy for preventing the world-wide epidemic of obesity.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Levin BEdoi
10.1016/j.yfrne.2010.02.005subject
Has Abstractpub_date
2010-07-01 00:00:00pages
270-83issue
3eissn
0091-3022issn
1095-6808pii
S0091-3022(10)00009-9journal_volume
31pub_type
杂志文章,评审abstract：:Exercise is known to have beneficial effects on cognition, mood, and the brain. However, exercise also activates the hypothalamic-pituitary-adrenal axis and increases levels of the glucocorticoid cortisol (CORT). CORT, also known as the "stress hormone," is considered a mediator between chronic stress and depression a...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2016.12.001
更新日期：2017-01-01 00:00:00
abstract：:In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and b...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/s0091-3022(02)00005-5
更新日期：2002-10-01 00:00:00
abstract：:The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：
更新日期：1992-07-01 00:00:00
abstract：:The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells. The TME emerged as a key modulator of tumour initiation, progression and invasion, with extensive data available in many cancers, but little is ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100852
更新日期：2020-07-01 00:00:00
abstract：:Two different approaches have been utilized to study the controlling mechanisms that underlie the generation and entrainment of circadian rhythms in mammals. The use of specific drugs to alter the period and/or the phase of circadian rhythms has provided new insights into both the pathways by which environmental infor...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1007
更新日期：1995-07-01 00:00:00
abstract：:In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2006.09.004
更新日期：2006-12-01 00:00:00
abstract：:Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.09.001
更新日期：2008-05-01 00:00:00
abstract：:Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively. Recent studies suggest that these neuropeptides may also signal via each other's receptors. The extent to which such cross-system signali...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.02.001
更新日期：2019-04-01 00:00:00
abstract：:In addition to its well documented action in female-typical behaviors, progesterone exerts an influence on the brain and behavior of males. This review will discuss the role of progesterone and its receptor in male-typical reproductive behaviors in adulthood and the role of progesterone and its receptor in neural deve...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2006.07.003
更新日期：2006-09-01 00:00:00
abstract：:There is considerable evidence that the central nervous system (CNS) is significantly involved in potassium homeostasis: (a) Potassium-specific receptors located in the liver or hepatic portal circulation initiate a reflex increase in potassium excretion via vagal afferents. This reflex is lost or diminished with hypo...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1993.1001
更新日期：1993-01-01 00:00:00
abstract：:The maternal microbiota is positioned to regulate the development of offspring immunity, metabolism, as well as brain function and behavior. The mechanisms by which maternal microbial signals drive these processes are beginning to be elucidated. In this review, we provide a brief overview on the importance of the micr...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100797
更新日期：2019-10-01 00:00:00
abstract：:This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2014.03.007
更新日期：2014-10-01 00:00:00
abstract：:Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also i...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2012.06.002
更新日期：2012-08-01 00:00:00
abstract：:The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.07.003
更新日期：2011-10-01 00:00:00
abstract：:Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in t...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.03.002
更新日期：2010-07-01 00:00:00
abstract：:This review examines recent advances in the study of the behavioral responses to deficits of body water and body sodium that in humans are accompanied by the sensations of thirst and salt appetite. Thirst and salt appetite are satisfied by ingesting water and salty substances. These behavioral responses to losses of b...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1997.0153
更新日期：1997-07-01 00:00:00
abstract：:The concept is proposed that polypeptide neurotrophic factors contribute to the developmental regulation of ovarian and hypothalamic function in mammals. Nerve growth factor (NGF) and neurotrophin-3, two members of the neurotrophin family, have been identified in the rat ovary and one of its receptors has been localiz...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：:The majority of pituitary adenomas are trophically stable and change relatively little in size over many years. A comparatively small proportion behave more aggressively and come to clinical attention through inappropriate hormone secretion or adverse effects on surrounding structures. True malignant behaviour with me...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/s0091-3022(03)00012-8
更新日期：2003-04-01 00:00:00
abstract：:Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100815
更新日期：2020-01-01 00:00:00
abstract：:This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It provides the development of our understanding of the neuroendocrine control of puberty since Harris proposed in his 1955 monograph (Harris, 1955) th...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2015.04.002
更新日期：2015-07-01 00:00:00
abstract：:Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2005.08.001
更新日期：2005-10-01 00:00:00
abstract：:Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100849
更新日期：2020-07-01 00:00:00
abstract：:Food reward, not hunger, is the main driving force behind eating in the modern obesogenic environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily overconsumed despite the resulting health consequences. Important advances have been made to explain mechanisms underlying excessive co...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2012.01.002
更新日期：2012-04-01 00:00:00
abstract：:Identification of novel neurohormones that regulate the reproductive axis is essential for the progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin modulate gonado...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.03.001
更新日期：2010-07-01 00:00:00
abstract：:Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) is the most common mouse model of MS. Treatments with the sex hormones, estrogens and androgens, are capable of offering disease protection during...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.12.001
更新日期：2012-01-01 00:00:00
abstract：:Initial investigations into the mechanistic basis of aggression focused on the role of testosterone (T) and a variety of studies on non-human animals found that elevated T levels promote aggression. However, many correlational studies have not detected a significant association between aggression and peripheral T leve...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2005.11.001
更新日期：2006-07-01 00:00:00
abstract：:Insight into the mechanisms of action of neurotrophic growth factors has been obtained through the identification and characterization of gene products that are regulated or modified at the transcriptional, translational, and/or posttranslational level in response to neurotrophin treatment. VGF (non-acronymic) was ide...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.2000.0199
更新日期：2000-07-01 00:00:00
abstract：:Appropriate regulatory control of the hypothalamo-pituitary-adrenocortical stress axis is essential to health and survival. The following review documents the principle extrinsic and intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the hypothalamic paraventricular nucleus, which summate...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2003.07.001
更新日期：2003-07-01 00:00:00
abstract：:Trans-generational epigenetic phenomena, such as contamination with endocrine-disrupting chemicals (EDCs) that decrease fertility and the global methylation status of DNA in the offspring, are of great concern because they may affect health, particularly the health of children. However, of even greater concern is the ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.12.004
更新日期：2008-06-01 00:00:00
abstract：:A rapidly growing body of evidence reveals that complex networks of communication exist between the neuroendocrine and the immune systems. Essential to the maintenance and function of the immune-endocrine circuitry are an array of chemical mediators produced by cells of the immune and endocrine systems. Cytokines are ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1001
更新日期：1995-01-01 00:00:00
