Neurodevelopmental effects of insulin-like growth factor signaling.

Abstract:

:Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also influence the growth and maturation of neural cells, augmenting dendritic growth and spine formation, axon outgrowth, synaptogenesis, and myelination. Specific IGF actions, however, likely depend on cell type, developmental stage, and local microenvironmental milieu within the brain. Emerging research also indicates that alterations in IGF signaling likely contribute to the pathogenesis of some neurological disorders. This review summarizes experimental studies and shed light on the critical roles of IGF signaling, as well as its mechanisms, during CNS development.

journal_name

Front Neuroendocrinol

authors

O'Kusky J,Ye P

doi

10.1016/j.yfrne.2012.06.002

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

230-51

issue

3

eissn

0091-3022

issn

1095-6808

pii

S0091-3022(12)00028-3

journal_volume

33

pub_type

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