Abstract:
:Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also influence the growth and maturation of neural cells, augmenting dendritic growth and spine formation, axon outgrowth, synaptogenesis, and myelination. Specific IGF actions, however, likely depend on cell type, developmental stage, and local microenvironmental milieu within the brain. Emerging research also indicates that alterations in IGF signaling likely contribute to the pathogenesis of some neurological disorders. This review summarizes experimental studies and shed light on the critical roles of IGF signaling, as well as its mechanisms, during CNS development.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
O'Kusky J,Ye Pdoi
10.1016/j.yfrne.2012.06.002subject
Has Abstractpub_date
2012-08-01 00:00:00pages
230-51issue
3eissn
0091-3022issn
1095-6808pii
S0091-3022(12)00028-3journal_volume
33pub_type
杂志文章,评审abstract::The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:
更新日期:1992-07-01 00:00:00
abstract::In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and b...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/s0091-3022(02)00005-5
更新日期:2002-10-01 00:00:00
abstract::Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiol...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.100768
更新日期:2019-07-01 00:00:00
abstract::Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2007.09.001
更新日期:2008-05-01 00:00:00
abstract::Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced ac...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2008.03.001
更新日期:2008-06-01 00:00:00
abstract::Initial investigations into the mechanistic basis of aggression focused on the role of testosterone (T) and a variety of studies on non-human animals found that elevated T levels promote aggression. However, many correlational studies have not detected a significant association between aggression and peripheral T leve...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2005.11.001
更新日期:2006-07-01 00:00:00
abstract::The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells. The TME emerged as a key modulator of tumour initiation, progression and invasion, with extensive data available in many cancers, but little is ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2020.100852
更新日期:2020-07-01 00:00:00
abstract::Neuroscientists are likely to discover new sex differences in the coming years, spurred by the National Institutes of Health initiative to include both sexes in preclinical studies. This review summarizes the current state of knowledge of the cellular and molecular mechanisms underlying sex differences in the mammalia...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.01.001
更新日期:2016-01-01 00:00:00
abstract::Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,meta分析
doi:10.1016/j.yfrne.2019.100775
更新日期:2019-07-01 00:00:00
abstract::A rapidly growing body of evidence reveals that complex networks of communication exist between the neuroendocrine and the immune systems. Essential to the maintenance and function of the immune-endocrine circuitry are an array of chemical mediators produced by cells of the immune and endocrine systems. Cytokines are ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1001
更新日期:1995-01-01 00:00:00
abstract::This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.03.007
更新日期:2014-10-01 00:00:00
abstract::Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribu...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2017.12.004
更新日期:2018-07-01 00:00:00
abstract::The pulsatile release of gonadotropin-releasing hormone (GnRH) into the portal vasculature is responsible for the maintenance of reproductive function. Levels of GnRH decapeptide available for this process can be regulated at transcriptional, posttranscriptional, and posttranslational levels. In the immortalized neuro...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1996.0149
更新日期:1997-04-01 00:00:00
abstract::17β-Estradiol (estradiol or E2) is implicated as a neuroprotective factor in a variety of neurodegenerative disorders. This review focuses on the mechanisms underlying E2 neuroprotection in cerebral ischemia, as well as emerging evidence from basic science and clinical studies, which suggests that there is a "critical...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.10.001
更新日期:2012-01-01 00:00:00
abstract::This review examines recent advances in the study of the behavioral responses to deficits of body water and body sodium that in humans are accompanied by the sensations of thirst and salt appetite. Thirst and salt appetite are satisfied by ingesting water and salty substances. These behavioral responses to losses of b...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1997.0153
更新日期:1997-07-01 00:00:00
abstract::Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1996.0013
更新日期:1996-10-01 00:00:00
abstract::Parental care is found widely across animal taxa and is manifest in a range of behaviours from basic provisioning in cockroaches to highly complex behaviours seen in mammals. The evolution of parental care is viewed as the outcome of an evolutionary cost/benefit trade-off between investing in current and future offspr...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2018.12.004
更新日期:2019-01-01 00:00:00
abstract::To cope with variations in the environment, most mammalian species exhibit seasonal cycles in physiology and behaviour. Seasonal plasticity during the lifetime contributes to seasonal physiology. Over the years, our ideas regarding adult brain plasticity and, more specifically, hypothalamic plasticity have greatly evo...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.11.004
更新日期:2015-04-01 00:00:00
abstract::Exercise is known to have beneficial effects on cognition, mood, and the brain. However, exercise also activates the hypothalamic-pituitary-adrenal axis and increases levels of the glucocorticoid cortisol (CORT). CORT, also known as the "stress hormone," is considered a mediator between chronic stress and depression a...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.12.001
更新日期:2017-01-01 00:00:00
abstract::Drug addiction is a chronically relapsing disorder characterized by loss of control over intake and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie Vale and his colleagues of corticotropin-releasing factor (CRF) and the structurally-related urocortins, CRF systems have emerged as ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.01.001
更新日期:2014-04-01 00:00:00
abstract::Human models demonstrate that experimental activation of the innate immune system has profound effects on brain activation and behavior, inducing fatigue, worsened mood and pain sensitivity. It has been proposed that inflammation is a mechanism involved in the etiology and maintenance of depression, chronic pain and l...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2018.06.005
更新日期:2018-07-01 00:00:00
abstract::Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2017.08.001
更新日期:2017-10-01 00:00:00
abstract::The immune system and the hypothalamic-pituitary (H-P) axis are functionally connected, so that exposure to antigens elicits a coordinated response which allows the organism to successfully withstand immunologic challenges. An important feature of this bilateral communication is the appearance of proteins released int...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1005
更新日期:1995-04-01 00:00:00
abstract::Clinical introduction of octreotide, a long-acting somatostatin analog, has opened a new era in the medical therapy of patients with growth hormone (GH)- and thyroid-stimulating hormone (TSH)-secreting pituitary tumors. Good control of hormonal hypersecretion occurred in most patients, and tumor shrinkage has been obs...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1993.1002
更新日期:1993-01-01 00:00:00
abstract::Two different approaches have been utilized to study the controlling mechanisms that underlie the generation and entrainment of circadian rhythms in mammals. The use of specific drugs to alter the period and/or the phase of circadian rhythms has provided new insights into both the pathways by which environmental infor...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1007
更新日期:1995-07-01 00:00:00
abstract::The hippocampus plays an integral role in certain aspects of cognition. Hippocampal structural plasticity and in particular adult hippocampal neurogenesis can be influenced by several intrinsic and extrinsic factors. Here we review how hormones (i.e., intrinsic modulators) and physical exercise (i.e., an extrinsic mod...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.03.001
更新日期:2016-04-01 00:00:00
abstract::Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such dis...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.12.004
更新日期:2015-07-01 00:00:00
abstract::A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1999.0184
更新日期:1999-10-01 00:00:00
abstract::Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2013.10.006
更新日期:2014-04-01 00:00:00
abstract::The concept is proposed that polypeptide neurotrophic factors contribute to the developmental regulation of ovarian and hypothalamic function in mammals. Nerve growth factor (NGF) and neurotrophin-3, two members of the neurotrophin family, have been identified in the rat ovary and one of its receptors has been localiz...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00