Abstract:
:Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for microbiota-brain communication in brain development, behavior, and brain function over the life span, clinical studies have started to consider the microbiome in psychiatric disorders. The composition, diversity and function of commensal microbes is influenced by genetic, lifestyle, and environmental factors. This review provides an overview of the factors contributing to individual differences in the microbiome, reviews recent work in psychiatric disorders, and considers what is needed to advance a better understanding of how the microbiome impacts mental health which may help us understand the heterogeneity observed in clinical psychiatric populations.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Hayes CL,Peters BJ,Foster JAdoi
10.1016/j.yfrne.2020.100849subject
Has Abstractpub_date
2020-07-01 00:00:00pages
100849eissn
0091-3022issn
1095-6808pii
S0091-3022(20)30040-6journal_volume
58pub_type
杂志文章,评审abstract::Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,meta分析
doi:10.1016/j.yfrne.2019.100775
更新日期:2019-07-01 00:00:00
abstract::Mounting evidence suggests that--beyond the well-known genomic effects--glucocorticoids affect cell function via non-genomic mechanisms. Such mechanisms operate in many major systems and organs including the cardiovascular, immune, endocrine and nervous systems, smooth and skeletal muscles, liver, and fat cells. Non-g...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2007.10.004
更新日期:2008-05-01 00:00:00
abstract::Mental illnesses originate early in life, governed by environmental and genetic factors. Because parents are a dominant source of signals to the developing child, parental signals - beginning with maternal signals in utero - are primary contributors to children's mental health. Existing literature on maternal signals ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.01.002
更新日期:2019-04-01 00:00:00
abstract::Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced ac...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2008.03.001
更新日期:2008-06-01 00:00:00
abstract::Initial investigations into the mechanistic basis of aggression focused on the role of testosterone (T) and a variety of studies on non-human animals found that elevated T levels promote aggression. However, many correlational studies have not detected a significant association between aggression and peripheral T leve...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2005.11.001
更新日期:2006-07-01 00:00:00
abstract::Many vertebrates are highly motivated to communicate, suggesting that the consequences of communication may be rewarding. Past studies show that dopamine and opioids in the medial preoptic nucleus (mPOA) and ventral tegmental area (VTA) play distinct roles in motivation and reward. In songbirds, multiple lines of rece...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2012.04.002
更新日期:2012-04-01 00:00:00
abstract::Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2007.09.001
更新日期:2008-05-01 00:00:00
abstract::The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease (PD) have not yet been clarified, and it is controversial whether there is a critical period for neuroprotection. Studies in animal models and clinical and epidemiological studies indicate that estrogens induce dopaminergic neuroprotecti...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.09.003
更新日期:2016-10-01 00:00:00
abstract::The immune system and the hypothalamic-pituitary (H-P) axis are functionally connected, so that exposure to antigens elicits a coordinated response which allows the organism to successfully withstand immunologic challenges. An important feature of this bilateral communication is the appearance of proteins released int...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1005
更新日期:1995-04-01 00:00:00
abstract::The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1994.1012
更新日期:1994-12-01 00:00:00
abstract::Two different approaches have been utilized to study the controlling mechanisms that underlie the generation and entrainment of circadian rhythms in mammals. The use of specific drugs to alter the period and/or the phase of circadian rhythms has provided new insights into both the pathways by which environmental infor...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1007
更新日期:1995-07-01 00:00:00
abstract::The extraction of cortisol from fingernails represents a recent advancement in the retrospective, long-term assessment of hypothalamic-pituitaryadrenal (HPA) axis activity: Fingernail cortisol has the potential to overcome some of the major disadvantages of established HPA axis markers. However, the introduction of an...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2020.100855
更新日期:2020-07-01 00:00:00
abstract::The majority of songbird species have sexually dimorphic neuronal circuits for song learning and production and these differences are paralleled by sex differences in behavior, with only males singing or singing at a higher rate than females. Therefore songbirds serve as an excellent model for studying the mechanisms ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2010.11.001
更新日期:2011-01-01 00:00:00
abstract::This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.03.007
更新日期:2014-10-01 00:00:00
abstract::A majority of birds are socially monogamous, providing exceptional opportunities to discover neuroendocrine mechanisms underlying preferences for opposite-sex partners where the sexes form extended affiliative relationships. Zebra finches have been the focus of the most systematic program of research to date in any so...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.01.003
更新日期:2011-04-01 00:00:00
abstract::The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:
更新日期:1992-07-01 00:00:00
abstract::The concept is proposed that polypeptide neurotrophic factors contribute to the developmental regulation of ovarian and hypothalamic function in mammals. Nerve growth factor (NGF) and neurotrophin-3, two members of the neurotrophin family, have been identified in the rat ovary and one of its receptors has been localiz...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00
abstract::Gene therapy, which entails the use of nucleic acids as drugs, is a new approach to treat disease. Gene therapy has been successfully implemented in several preclinical animal models, including several paradigms of experimental pituitary tumors. In spite of these successes, several critical issues need to be addressed...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/s0091-3022(02)00106-1
更新日期:2003-01-01 00:00:00
abstract::In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and b...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/s0091-3022(02)00005-5
更新日期:2002-10-01 00:00:00
abstract::Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2005.08.001
更新日期:2005-10-01 00:00:00
abstract::Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in t...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2010.03.002
更新日期:2010-07-01 00:00:00
abstract::Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiol...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.100768
更新日期:2019-07-01 00:00:00
abstract::A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1999.0184
更新日期:1999-10-01 00:00:00
abstract::Female sexual behavior in rodents, typified by the lordosis posture, is hormone-dependent and sex-specific. Ovarian hormones control this behavior via receptors in the hypothalamic ventromedial nucleus (VMH). This review considers the sex differences in the morphology, neurochemistry and neural circuitry of the VMH to...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.02.008
更新日期:2011-04-01 00:00:00
abstract::This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinn...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2018.12.001
更新日期:2019-01-01 00:00:00
abstract::Lipids are essential for cellular functioning considering their role in membrane composition, signaling, and energy metabolism. The brain is the second most abundant organ in terms of lipid concentration and diversity only after adipose tissue. However, in the central system (CNS) lipid dysregulation has been linked t...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2021.100899
更新日期:2021-01-12 00:00:00
abstract::In addition to its well documented action in female-typical behaviors, progesterone exerts an influence on the brain and behavior of males. This review will discuss the role of progesterone and its receptor in male-typical reproductive behaviors in adulthood and the role of progesterone and its receptor in neural deve...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2006.07.003
更新日期:2006-09-01 00:00:00
abstract::The pulsatile release of gonadotropin-releasing hormone (GnRH) into the portal vasculature is responsible for the maintenance of reproductive function. Levels of GnRH decapeptide available for this process can be regulated at transcriptional, posttranscriptional, and posttranslational levels. In the immortalized neuro...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1996.0149
更新日期:1997-04-01 00:00:00
abstract::Drug addiction is a chronically relapsing disorder characterized by loss of control over intake and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie Vale and his colleagues of corticotropin-releasing factor (CRF) and the structurally-related urocortins, CRF systems have emerged as ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.01.001
更新日期:2014-04-01 00:00:00
abstract::Sex chromosome genes directly influence sex differences in behavior. The discovery of the Sry gene on the Y chromosome (Gubbay et al., 1990; Koopman et al., 1990) substantiated the sex chromosome mechanistic link to sex differences. Moreover, the pronounced connection between X chromosome gene mutations and mental ill...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2013.12.004
更新日期:2014-10-01 00:00:00