Abstract:
:Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus that serve as the last step in synaptic integration before neurohormone release. While these synapses exhibit many similarities with other glutamate synapses described throughout the brain, they also exhibit a number of unique properties that are particularly well suited to the physiology of this system and will be discussed here. In addition, a number of recent studies begin to provide insights into new forms of synaptic plasticity that may be common in other brain regions, but in these cells, may serve important adaptive roles.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Iremonger KJ,Benediktsson AM,Bains JSdoi
10.1016/j.yfrne.2010.03.002subject
Has Abstractpub_date
2010-07-01 00:00:00pages
296-306issue
3eissn
0091-3022issn
1095-6808pii
S0091-3022(10)00024-5journal_volume
31pub_type
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