Abstract：
:Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively. Recent studies suggest that these neuropeptides may also signal via each other's receptors. The extent to which such cross-system signaling occurs likely depends on anatomical overlap between AVP/OXT fibers and V1aR/OTR expression. By comparing AVP/OXT fiber densities with V1aR/OTR binding densities throughout the rat social behavior neural network (SBNN), we propose the potential for cross-system signaling in four regions: the medial amygdala (MeA), bed nucleus of the stria terminalis (BNSTp), medial preoptic area, and periaqueductal grey. We also discuss possible implications of corresponding sex (higher in males versus females) and age (higher in adults versus juveniles) differences in AVP fiber and OTR binding densities in the MeA and BNSTp. Overall, this review reveals the need to unravel the consequences of potential cross-system signaling between AVP and OXT systems in the SBNN for the regulation of social behavior.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Smith CJW,DiBenedictis BT,Veenema AHdoi
10.1016/j.yfrne.2019.02.001subject
Has Abstractpub_date
2019-04-01 00:00:00pages
100737eissn
0091-3022issn
1095-6808pii
S0091-3022(19)30007-Xjournal_volume
53pub_type
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