Influence of immune signals on the hypothalamic-pituitary axis of the rodent.

Abstract:

:The immune system and the hypothalamic-pituitary (H-P) axis are functionally connected, so that exposure to antigens elicits a coordinated response which allows the organism to successfully withstand immunologic challenges. An important feature of this bilateral communication is the appearance of proteins released into the circulation by activated immune cells. These proteins, called cytokines or interleukins, stimulate the activity of the H-P axis, thus increasing circulating ACTH and corticosteroid levels. This in turn induces metabolic changes such as increases in energy substrates, restrains the activity of specific immune cells, and alters the release of secretagogues important for both the immune system and neuroendocrine organs. After acute increases in blood-borne levels of cytokines, nerve terminals in the median eminence, particularly those containing corticotropin-releasing factor (CRF), represent an important site of action of these immune signals. Subsequently, changes take place within the brain in general and the hypothalamus in particular. They include the synthesis/release of peptides such as CRF and vasopressin, of neurotransmitters such as catecholamines and prostaglandins, and of cytokines themselves. Upon prolonged exposure to blood-borne immune signals additional mechanisms come into play, including those taking place directly at the pituitary level. These observations indicate that cytokines released into the general circulation act on multiple sites within the H-P axis, a phenomenon that relies on the recruitment of a large number of pathways. This review discusses these pathways and the mechanisms through which they allow cytokines to convey the occurrence of immune activation to the brain.

journal_name

Front Neuroendocrinol

authors

Rivier C

doi

10.1006/frne.1995.1005

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

151-82

issue

2

eissn

0091-3022

issn

1095-6808

pii

S0091-3022(85)71005-9

journal_volume

16

pub_type

杂志文章,评审
  • The natriuretic peptide system in the brain: implications in the central control of cardiovascular and neuroendocrine functions.

    abstract::The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:

    authors: Imura H,Nakao K,Itoh H

    更新日期:1992-07-01 00:00:00

  • Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: Implications for cross-system signaling.

    abstract::Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively. Recent studies suggest that these neuropeptides may also signal via each other's receptors. The extent to which such cross-system signali...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2019.02.001

    authors: Smith CJW,DiBenedictis BT,Veenema AH

    更新日期:2019-04-01 00:00:00

  • Developmental gene x environment interactions affecting systems regulating energy homeostasis and obesity.

    abstract::Most human obesity is inherited as a polygenic trait which is largely refractory to medical therapy because obese individuals avidly defend their elevated body weight set-point. This set-point is mediated by an integrated neural network that controls energy homeostasis. Epidemiological studies suggest that perinatal a...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2010.02.005

    authors: Levin BE

    更新日期:2010-07-01 00:00:00

  • Seasonal regulation of structural plasticity and neurogenesis in the adult mammalian brain: focus on the sheep hypothalamus.

    abstract::To cope with variations in the environment, most mammalian species exhibit seasonal cycles in physiology and behaviour. Seasonal plasticity during the lifetime contributes to seasonal physiology. Over the years, our ideas regarding adult brain plasticity and, more specifically, hypothalamic plasticity have greatly evo...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2014.11.004

    authors: Migaud M,Butrille L,Batailler M

    更新日期:2015-04-01 00:00:00

  • Roles of inhibins, activins, and follistatin in the female reproductive system.

    abstract::Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1996.0013

    authors: Knight PG

    更新日期:1996-10-01 00:00:00

  • Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevance.

    abstract::Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2013.10.006

    authors: Rivier JE,Rivier CL

    更新日期:2014-04-01 00:00:00

  • The neuroendocrinology of thirst and salt appetite: visceral sensory signals and mechanisms of central integration.

    abstract::This review examines recent advances in the study of the behavioral responses to deficits of body water and body sodium that in humans are accompanied by the sensations of thirst and salt appetite. Thirst and salt appetite are satisfied by ingesting water and salty substances. These behavioral responses to losses of b...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1997.0153

    authors: Johnson AK,Thunhorst RL

    更新日期:1997-07-01 00:00:00

  • The song remains the same: coactivators and sex differences in the songbird brain.

    abstract::The majority of songbird species have sexually dimorphic neuronal circuits for song learning and production and these differences are paralleled by sex differences in behavior, with only males singing or singing at a higher rate than females. Therefore songbirds serve as an excellent model for studying the mechanisms ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2010.11.001

    authors: Duncan KA,Carruth LL

    更新日期:2011-01-01 00:00:00

  • Epigenetics, brain evolution and behaviour.

    abstract::Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced ac...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2008.03.001

    authors: Keverne EB,Curley JP

    更新日期:2008-06-01 00:00:00

  • Pathophysiological mechanisms implicated in postpartum depression.

    abstract::This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinn...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2018.12.001

    authors: Payne JL,Maguire J

    更新日期:2019-01-01 00:00:00

  • Fast glucocorticoid actions on brain: back to the future.

    abstract::Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2005.08.001

    authors: Dallman MF

    更新日期:2005-10-01 00:00:00

  • Neuroimaging premenstrual dysphoric disorder: A systematic and critical review.

    abstract::Endocrine organizational and activational influences on cognitive and affective circuits are likely critical to the development of premenstrual dysphoric disorder (PMDD), a sex-specific hormone-dependent mood disorder. An overview of the anatomical and functional neural characterization of this disorder is presented h...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2020.100838

    authors: Dubol M,Epperson CN,Lanzenberger R,Sundström-Poromaa I,Comasco E

    更新日期:2020-04-01 00:00:00

  • Regulation of gene promoters of hypothalamic peptides.

    abstract::In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and b...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/s0091-3022(02)00005-5

    authors: Burbach JP

    更新日期:2002-10-01 00:00:00

  • Reflexive testosterone release: a model system for studying the nongenomic effects of testosterone upon male behavior.

    abstract::Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2007.09.001

    authors: Nyby JG

    更新日期:2008-05-01 00:00:00

  • Mouse model systems to study sex chromosome genes and behavior: relevance to humans.

    abstract::Sex chromosome genes directly influence sex differences in behavior. The discovery of the Sry gene on the Y chromosome (Gubbay et al., 1990; Koopman et al., 1990) substantiated the sex chromosome mechanistic link to sex differences. Moreover, the pronounced connection between X chromosome gene mutations and mental ill...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2013.12.004

    authors: Cox KH,Bonthuis PJ,Rissman EF

    更新日期:2014-10-01 00:00:00

  • The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings.

    abstract::Mounting evidence suggests that--beyond the well-known genomic effects--glucocorticoids affect cell function via non-genomic mechanisms. Such mechanisms operate in many major systems and organs including the cardiovascular, immune, endocrine and nervous systems, smooth and skeletal muscles, liver, and fat cells. Non-g...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2007.10.004

    authors: Haller J,Mikics E,Makara GB

    更新日期:2008-05-01 00:00:00

  • Neuroendocrine contributions to sexual partner preference in birds.

    abstract::A majority of birds are socially monogamous, providing exceptional opportunities to discover neuroendocrine mechanisms underlying preferences for opposite-sex partners where the sexes form extended affiliative relationships. Zebra finches have been the focus of the most systematic program of research to date in any so...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2011.01.003

    authors: Adkins-Regan E

    更新日期:2011-04-01 00:00:00

  • Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS.

    abstract::In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2006.09.004

    authors: Scharfman HE,MacLusky NJ

    更新日期:2006-12-01 00:00:00

  • Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues.

    abstract::Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2017.08.001

    authors: Rosenfeld CS

    更新日期:2017-10-01 00:00:00

  • Assessing viral gene therapy in neuroendocrine models.

    abstract::A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1999.0184

    authors: Geddes BJ,Harding TC,Lightman SL,Uney JB

    更新日期:1999-10-01 00:00:00

  • Sex differences in attention Deficit Hyperactivity Disorder: candidate genetic and endocrine mechanisms.

    abstract::Attention Deficit Hyperactivity Disorder (ADHD) is a developmental condition characterised by severe inattention, pathological impulsivity and hyperactivity; it is relatively common affecting up to 6% of children, and is associated with a risk of long-term adverse educational and social consequences. Males are conside...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2014.03.003

    authors: Davies W

    更新日期:2014-08-01 00:00:00

  • Molecular defects in the pathogenesis of pituitary tumours.

    abstract::The majority of pituitary adenomas are trophically stable and change relatively little in size over many years. A comparatively small proportion behave more aggressively and come to clinical attention through inappropriate hormone secretion or adverse effects on surrounding structures. True malignant behaviour with me...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/s0091-3022(03)00012-8

    authors: Levy A,Lightman S

    更新日期:2003-04-01 00:00:00

  • Sex differences in how inflammation affects behavior: What we can learn from experimental inflammatory models in humans.

    abstract::Human models demonstrate that experimental activation of the innate immune system has profound effects on brain activation and behavior, inducing fatigue, worsened mood and pain sensitivity. It has been proposed that inflammation is a mechanism involved in the etiology and maintenance of depression, chronic pain and l...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2018.06.005

    authors: Lasselin J,Lekander M,Axelsson J,Karshikoff B

    更新日期:2018-07-01 00:00:00

  • The EDGE hypothesis: epigenetically directed genetic errors in repeat-containing proteins (RCPs) involved in evolution, neuroendocrine signaling, and cancer.

    abstract::Trans-generational epigenetic phenomena, such as contamination with endocrine-disrupting chemicals (EDCs) that decrease fertility and the global methylation status of DNA in the offspring, are of great concern because they may affect health, particularly the health of children. However, of even greater concern is the ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2007.12.004

    authors: Ruden DM,Jamison DC,Zeeberg BR,Garfinkel MD,Weinstein JN,Rasouli P,Lu X

    更新日期:2008-06-01 00:00:00

  • Sex differences in the neural circuit that mediates female sexual receptivity.

    abstract::Female sexual behavior in rodents, typified by the lordosis posture, is hormone-dependent and sex-specific. Ovarian hormones control this behavior via receptors in the hypothalamic ventromedial nucleus (VMH). This review considers the sex differences in the morphology, neurochemistry and neural circuitry of the VMH to...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2011.02.008

    authors: Flanagan-Cato LM

    更新日期:2011-04-01 00:00:00

  • Pharmacological and genetic approaches for the study of circadian rhythms in mammals.

    abstract::Two different approaches have been utilized to study the controlling mechanisms that underlie the generation and entrainment of circadian rhythms in mammals. The use of specific drugs to alter the period and/or the phase of circadian rhythms has provided new insights into both the pathways by which environmental infor...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1995.1007

    authors: Turek FW,Pinto LH,Vitaterna MH,Penev PD,Zee PC,Takahashi JS

    更新日期:1995-07-01 00:00:00

  • Microbes and mental health: Can the microbiome help explain clinical heterogeneity in psychiatry?

    abstract::Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2020.100849

    authors: Hayes CL,Peters BJ,Foster JA

    更新日期:2020-07-01 00:00:00

  • Neurodevelopmental effects of insulin-like growth factor signaling.

    abstract::Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also i...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2012.06.002

    authors: O'Kusky J,Ye P

    更新日期:2012-08-01 00:00:00

  • The metamorphosis of adolescent hormonal stress reactivity: A focus on animal models.

    abstract::As adolescents transition from childhood to adulthood, many physiological and neurobehavioral changes occur. Shifts in neuroendocrine function are one such change, including the hormonal systems that respond to stressors. This review will focus on these hormonal changes, with a particular emphasis on the pubertal and ...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yfrne.2017.12.003

    authors: Romeo RD

    更新日期:2018-04-01 00:00:00

  • The central nervous system in potassium homeostasis.

    abstract::There is considerable evidence that the central nervous system (CNS) is significantly involved in potassium homeostasis: (a) Potassium-specific receptors located in the liver or hepatic portal circulation initiate a reflex increase in potassium excretion via vagal afferents. This reflex is lost or diminished with hypo...

    journal_title:Frontiers in neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1006/frne.1993.1001

    authors: Rabinowitz L,Aizman RI

    更新日期:1993-01-01 00:00:00