Abstract:
:This review examines recent advances in the study of the behavioral responses to deficits of body water and body sodium that in humans are accompanied by the sensations of thirst and salt appetite. Thirst and salt appetite are satisfied by ingesting water and salty substances. These behavioral responses to losses of body fluids, together with reflex endocrine and neural responses, are critical for reestablishing homeostasis. Like their endocrine and neural counterparts, these behaviors are under the control of both excitatory and inhibitory influences arising from changes in osmolality, endocrine factors such as angiotensin and aldosterone, and neural signals from low and high pressure baroreceptors. The excitatory and inhibitory influences reaching the brain require the integrative capacity of a neural network which includes the structures of the lamina terminalis, the amygdala, the perifornical area, and the paraventricular nucleus in the forebrain, and the lateral parabrachial nucleus (LPBN), the nucleus tractus solitarius (NTS), and the area postrema in the hindbrain. These regions are discussed in terms of their roles in receiving afferent sensory input and in processing information related to hydromineral balance. Osmoreceptors controlling thirst are located in systemic viscera and in central structures that lack the blood-brain barrier. Angiotensin and aldosterone act on and through structures of the lamina terminalis and the amygdala to stimulate thirst and sodium appetite under conditions of hypovolemia. The NTS and LPBN receive neural signals from baroreceptors and are responsible for inhibiting the ingestion of fluids under conditions of increased volume and pressure and for stimulating thirst under conditions of hypovolemia and hypotension. The interplay of multiple facilitory influences within the brain may take the form of interactions between descending angiotensinergic systems originating in the forebrain and ascending adrenergic systems emanating from the hindbrain. Oxytocin and serotonin are additional candidate neurochemicals with postulated inhibitory central actions and with essential roles in the overall integration of sensory input within the neural network devoted to maintaining hydromineral balance.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Johnson AK,Thunhorst RLdoi
10.1006/frne.1997.0153subject
Has Abstractpub_date
1997-07-01 00:00:00pages
292-353issue
3eissn
0091-3022issn
1095-6808pii
S0091-3022(97)90153-9journal_volume
18pub_type
杂志文章,评审abstract::Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,meta分析
doi:10.1016/j.yfrne.2019.100775
更新日期:2019-07-01 00:00:00
abstract::The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival - are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.100766
更新日期:2019-07-01 00:00:00
abstract::Psychosocial stress, and within the neuroendocrine reaction to stress specifically the glucocorticoid hormones, are well-characterized inhibitors of neural stem/progenitor cell proliferation in the adult hippocampus, resulting in a marked reduction in the production of new neurons in this brain area relevant for learn...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.05.001
更新日期:2016-04-01 00:00:00
abstract::Human models demonstrate that experimental activation of the innate immune system has profound effects on brain activation and behavior, inducing fatigue, worsened mood and pain sensitivity. It has been proposed that inflammation is a mechanism involved in the etiology and maintenance of depression, chronic pain and l...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2018.06.005
更新日期:2018-07-01 00:00:00
abstract::The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.07.003
更新日期:2011-10-01 00:00:00
abstract::Clinical introduction of octreotide, a long-acting somatostatin analog, has opened a new era in the medical therapy of patients with growth hormone (GH)- and thyroid-stimulating hormone (TSH)-secreting pituitary tumors. Good control of hormonal hypersecretion occurred in most patients, and tumor shrinkage has been obs...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1993.1002
更新日期:1993-01-01 00:00:00
abstract::Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such dis...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.12.004
更新日期:2015-07-01 00:00:00
abstract::Organisms living outside the tropics use changes in photoperiod to adapt to seasonal changes in the environment. Several models have contributed to an understanding of this mechanism at the molecular and endocrine levels. Subtropical birds are excellent models for the study of these mechanisms because of their rapid a...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2013.04.002
更新日期:2013-08-01 00:00:00
abstract::The pulsatile release of gonadotropin-releasing hormone (GnRH) into the portal vasculature is responsible for the maintenance of reproductive function. Levels of GnRH decapeptide available for this process can be regulated at transcriptional, posttranscriptional, and posttranslational levels. In the immortalized neuro...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1996.0149
更新日期:1997-04-01 00:00:00
abstract::This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.03.007
更新日期:2014-10-01 00:00:00
abstract::The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells. The TME emerged as a key modulator of tumour initiation, progression and invasion, with extensive data available in many cancers, but little is ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2020.100852
更新日期:2020-07-01 00:00:00
abstract::Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribu...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2017.12.004
更新日期:2018-07-01 00:00:00
abstract::Sex chromosome genes directly influence sex differences in behavior. The discovery of the Sry gene on the Y chromosome (Gubbay et al., 1990; Koopman et al., 1990) substantiated the sex chromosome mechanistic link to sex differences. Moreover, the pronounced connection between X chromosome gene mutations and mental ill...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2013.12.004
更新日期:2014-10-01 00:00:00
abstract::Attention Deficit Hyperactivity Disorder (ADHD) is a developmental condition characterised by severe inattention, pathological impulsivity and hyperactivity; it is relatively common affecting up to 6% of children, and is associated with a risk of long-term adverse educational and social consequences. Males are conside...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.03.003
更新日期:2014-08-01 00:00:00
abstract::Developmental studies of hormones and behavior often include littermates-rodent siblings that share early-life experiences and genes. Due to between-litter variation (i.e., litter effects), the statistical assumption of independent observations is untenable. In two literatures-natural variation in maternal care and pr...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2017.08.003
更新日期:2017-10-01 00:00:00
abstract::Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1996.0013
更新日期:1996-10-01 00:00:00
abstract::Parental care is found widely across animal taxa and is manifest in a range of behaviours from basic provisioning in cockroaches to highly complex behaviours seen in mammals. The evolution of parental care is viewed as the outcome of an evolutionary cost/benefit trade-off between investing in current and future offspr...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2018.12.004
更新日期:2019-01-01 00:00:00
abstract::Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2013.10.006
更新日期:2014-04-01 00:00:00
abstract::Lipids are essential for cellular functioning considering their role in membrane composition, signaling, and energy metabolism. The brain is the second most abundant organ in terms of lipid concentration and diversity only after adipose tissue. However, in the central system (CNS) lipid dysregulation has been linked t...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2021.100899
更新日期:2021-01-12 00:00:00
abstract::Gene therapy, which entails the use of nucleic acids as drugs, is a new approach to treat disease. Gene therapy has been successfully implemented in several preclinical animal models, including several paradigms of experimental pituitary tumors. In spite of these successes, several critical issues need to be addressed...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/s0091-3022(02)00106-1
更新日期:2003-01-01 00:00:00
abstract::Neuroscientists are likely to discover new sex differences in the coming years, spurred by the National Institutes of Health initiative to include both sexes in preclinical studies. This review summarizes the current state of knowledge of the cellular and molecular mechanisms underlying sex differences in the mammalia...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.01.001
更新日期:2016-01-01 00:00:00
abstract::Mental illnesses originate early in life, governed by environmental and genetic factors. Because parents are a dominant source of signals to the developing child, parental signals - beginning with maternal signals in utero - are primary contributors to children's mental health. Existing literature on maternal signals ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.01.002
更新日期:2019-04-01 00:00:00
abstract::Two different approaches have been utilized to study the controlling mechanisms that underlie the generation and entrainment of circadian rhythms in mammals. The use of specific drugs to alter the period and/or the phase of circadian rhythms has provided new insights into both the pathways by which environmental infor...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1007
更新日期:1995-07-01 00:00:00
abstract::Exercise is known to have beneficial effects on cognition, mood, and the brain. However, exercise also activates the hypothalamic-pituitary-adrenal axis and increases levels of the glucocorticoid cortisol (CORT). CORT, also known as the "stress hormone," is considered a mediator between chronic stress and depression a...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.12.001
更新日期:2017-01-01 00:00:00
abstract::The hippocampus plays an integral role in certain aspects of cognition. Hippocampal structural plasticity and in particular adult hippocampal neurogenesis can be influenced by several intrinsic and extrinsic factors. Here we review how hormones (i.e., intrinsic modulators) and physical exercise (i.e., an extrinsic mod...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.03.001
更新日期:2016-04-01 00:00:00
abstract::Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) is the most common mouse model of MS. Treatments with the sex hormones, estrogens and androgens, are capable of offering disease protection during...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.12.001
更新日期:2012-01-01 00:00:00
abstract::In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2006.09.004
更新日期:2006-12-01 00:00:00
abstract::This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinn...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2018.12.001
更新日期:2019-01-01 00:00:00
abstract::The immune system and the hypothalamic-pituitary (H-P) axis are functionally connected, so that exposure to antigens elicits a coordinated response which allows the organism to successfully withstand immunologic challenges. An important feature of this bilateral communication is the appearance of proteins released int...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1005
更新日期:1995-04-01 00:00:00
abstract::The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1994.1012
更新日期:1994-12-01 00:00:00