The tumour microenvironment of pituitary neuroendocrine tumours.

abstract：:In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...

journal_title：Frontiers in neuroendocrinology

authors： Scharfman HE,MacLusky NJ

更新日期：2006-12-01 00:00:00

abstract：:A 37-kDa corticotropin releasing factor (CRF) binding protein (CRF-BP) was purified from human plasma by repeated affinity purification and subsequently sequenced and cloned. The human and rat CRF-BP cDNAs encode proteins of 322 amino acids with one putative signal sequence, one N-glycosylation site, and 10 conserved ...

journal_title：Frontiers in neuroendocrinology

authors： Behan DP,De Souza EB,Lowry PJ,Potter E,Sawchenko P,Vale WW

更新日期：1995-10-01 00:00:00

abstract：:Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...

journal_title：Frontiers in neuroendocrinology

authors： Engel S,Laufer S,Miller R,Niemeyer H,Knaevelsrud C,Schumacher S

更新日期：2019-07-01 00:00:00

abstract：:Identification of novel neurohormones that regulate the reproductive axis is essential for the progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin modulate gonado...

journal_title：Frontiers in neuroendocrinology

authors： Tsutsui K,Bentley GE,Bedecarrats G,Osugi T,Ubuka T,Kriegsfeld LJ

更新日期：2010-07-01 00:00:00

abstract：:This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It provides the development of our understanding of the neuroendocrine control of puberty since Harris proposed in his 1955 monograph (Harris, 1955) th...

journal_title：Frontiers in neuroendocrinology

authors： Plant TM

更新日期：2015-07-01 00:00:00

abstract：:Attention Deficit Hyperactivity Disorder (ADHD) is a developmental condition characterised by severe inattention, pathological impulsivity and hyperactivity; it is relatively common affecting up to 6% of children, and is associated with a risk of long-term adverse educational and social consequences. Males are conside...

journal_title：Frontiers in neuroendocrinology

authors： Davies W

更新日期：2014-08-01 00:00:00

abstract：:This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...

journal_title：Frontiers in neuroendocrinology

authors： Olza-Fernández I,Marín Gabriel MA,Gil-Sanchez A,Garcia-Segura LM,Arevalo MA

更新日期：2014-10-01 00:00:00

abstract：:Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced ac...

journal_title：Frontiers in neuroendocrinology

authors： Keverne EB,Curley JP

更新日期：2008-06-01 00:00:00

abstract：:The hippocampus plays an integral role in certain aspects of cognition. Hippocampal structural plasticity and in particular adult hippocampal neurogenesis can be influenced by several intrinsic and extrinsic factors. Here we review how hormones (i.e., intrinsic modulators) and physical exercise (i.e., an extrinsic mod...

journal_title：Frontiers in neuroendocrinology

authors： Triviño-Paredes J,Patten AR,Gil-Mohapel J,Christie BR

更新日期：2016-04-01 00:00:00

abstract：:In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and b...

journal_title：Frontiers in neuroendocrinology

authors： Burbach JP

更新日期：2002-10-01 00:00:00

abstract：:The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival - are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of ...

journal_title：Frontiers in neuroendocrinology

authors： Swain JE,Ho SS,Fox H,Garry D,Brummelte S

更新日期：2019-07-01 00:00:00

abstract：:Exercise is known to have beneficial effects on cognition, mood, and the brain. However, exercise also activates the hypothalamic-pituitary-adrenal axis and increases levels of the glucocorticoid cortisol (CORT). CORT, also known as the "stress hormone," is considered a mediator between chronic stress and depression a...

journal_title：Frontiers in neuroendocrinology

authors： Chen C,Nakagawa S,An Y,Ito K,Kitaichi Y,Kusumi I

更新日期：2017-01-01 00:00:00

abstract：:A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...

journal_title：Frontiers in neuroendocrinology

authors： Geddes BJ,Harding TC,Lightman SL,Uney JB

更新日期：1999-10-01 00:00:00

abstract：:Drug addiction is a chronically relapsing disorder characterized by loss of control over intake and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie Vale and his colleagues of corticotropin-releasing factor (CRF) and the structurally-related urocortins, CRF systems have emerged as ...

journal_title：Frontiers in neuroendocrinology

authors： Zorrilla EP,Logrip ML,Koob GF

更新日期：2014-04-01 00:00:00

abstract：:Food reward, not hunger, is the main driving force behind eating in the modern obesogenic environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily overconsumed despite the resulting health consequences. Important advances have been made to explain mechanisms underlying excessive co...

journal_title：Frontiers in neuroendocrinology

authors： Alsiö J,Olszewski PK,Levine AS,Schiöth HB

更新日期：2012-04-01 00:00:00

abstract：:Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...

journal_title：Frontiers in neuroendocrinology

authors： Knight PG

更新日期：1996-10-01 00:00:00

abstract：:Mental illnesses originate early in life, governed by environmental and genetic factors. Because parents are a dominant source of signals to the developing child, parental signals - beginning with maternal signals in utero - are primary contributors to children's mental health. Existing literature on maternal signals ...

journal_title：Frontiers in neuroendocrinology

authors： Glynn LM,Baram TZ

更新日期：2019-04-01 00:00:00

abstract：:The maternal microbiota is positioned to regulate the development of offspring immunity, metabolism, as well as brain function and behavior. The mechanisms by which maternal microbial signals drive these processes are beginning to be elucidated. In this review, we provide a brief overview on the importance of the micr...

journal_title：Frontiers in neuroendocrinology

authors： Jašarević E,Bale TL

更新日期：2019-10-01 00:00:00

abstract：:Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for ...

journal_title：Frontiers in neuroendocrinology

authors： Hayes CL,Peters BJ,Foster JA

更新日期：2020-07-01 00:00:00

abstract：:Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in t...

journal_title：Frontiers in neuroendocrinology

authors： Iremonger KJ,Benediktsson AM,Bains JS

更新日期：2010-07-01 00:00:00

abstract：:The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...

journal_title：Frontiers in neuroendocrinology

authors： Miller AD,Leslie RA

更新日期：1994-12-01 00:00:00

abstract：:The immune system and the hypothalamic-pituitary (H-P) axis are functionally connected, so that exposure to antigens elicits a coordinated response which allows the organism to successfully withstand immunologic challenges. An important feature of this bilateral communication is the appearance of proteins released int...

journal_title：Frontiers in neuroendocrinology

authors： Rivier C

更新日期：1995-04-01 00:00:00

abstract：:Clinical introduction of octreotide, a long-acting somatostatin analog, has opened a new era in the medical therapy of patients with growth hormone (GH)- and thyroid-stimulating hormone (TSH)-secreting pituitary tumors. Good control of hormonal hypersecretion occurred in most patients, and tumor shrinkage has been obs...

journal_title：Frontiers in neuroendocrinology

authors： Lamberts SW,Hofland LJ,de Herder WW,Kwekkeboom DJ,Reubi JC,Krenning EP

更新日期：1993-01-01 00:00:00

abstract：:Lipids are essential for cellular functioning considering their role in membrane composition, signaling, and energy metabolism. The brain is the second most abundant organ in terms of lipid concentration and diversity only after adipose tissue. However, in the central system (CNS) lipid dysregulation has been linked t...

journal_title：Frontiers in neuroendocrinology

authors： Castellanos DB,Martín-Jiménez CA,Rojas-Rodríguez F,Barreto GE,González J

更新日期：2021-01-12 00:00:00

abstract：:Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) is the most common mouse model of MS. Treatments with the sex hormones, estrogens and androgens, are capable of offering disease protection during...

journal_title：Frontiers in neuroendocrinology

authors： Spence RD,Voskuhl RR

更新日期：2012-01-01 00:00:00

abstract：:Mounting evidence suggests that--beyond the well-known genomic effects--glucocorticoids affect cell function via non-genomic mechanisms. Such mechanisms operate in many major systems and organs including the cardiovascular, immune, endocrine and nervous systems, smooth and skeletal muscles, liver, and fat cells. Non-g...

journal_title：Frontiers in neuroendocrinology

authors： Haller J,Mikics E,Makara GB

更新日期：2008-05-01 00:00:00

abstract：:Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex ...

journal_title：Frontiers in neuroendocrinology

authors： Jaggar M,Rea K,Spichak S,Dinan TG,Cryan JF

更新日期：2020-01-01 00:00:00

abstract：:Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...

journal_title：Frontiers in neuroendocrinology

authors： Dallman MF

更新日期：2005-10-01 00:00:00

abstract：:The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...

journal_title：Frontiers in neuroendocrinology

authors： Imura H,Nakao K,Itoh H

更新日期：1992-07-01 00:00:00

abstract：:A majority of birds are socially monogamous, providing exceptional opportunities to discover neuroendocrine mechanisms underlying preferences for opposite-sex partners where the sexes form extended affiliative relationships. Zebra finches have been the focus of the most systematic program of research to date in any so...

journal_title：Frontiers in neuroendocrinology

authors： Adkins-Regan E

更新日期：2011-04-01 00:00:00