Abstract:
:Drug addiction is a chronically relapsing disorder characterized by loss of control over intake and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie Vale and his colleagues of corticotropin-releasing factor (CRF) and the structurally-related urocortins, CRF systems have emerged as mediators of the body's response to stress. Relatedly, CRF systems have a prominent role in driving addiction via actions in the central extended amygdala, producing anxiety-like behavior, reward deficits, excessive, compulsive-like drug self-administration and stress-induced reinstatement of drug seeking. CRF neuron activation in the medial prefrontal cortex may also contribute to the loss of control. Polymorphisms in CRF system molecules are associated with drug use phenotypes in humans, often in interaction with stress history. Drug discovery efforts have yielded brain-penetrant CRF1 antagonists with activity in preclinical models of addiction. The results support the hypothesis that brain CRF-CRF1 systems contribute to the etiology and maintenance of addiction.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Zorrilla EP,Logrip ML,Koob GFdoi
10.1016/j.yfrne.2014.01.001subject
Has Abstractpub_date
2014-04-01 00:00:00pages
234-44issue
2eissn
0091-3022issn
1095-6808pii
S0091-3022(14)00002-8journal_volume
35pub_type
杂志文章,评审abstract::Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...
journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.07.003
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2012.01.002
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.12.004
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.12.001
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/s0091-3022(03)00012-8
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2014.11.004
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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abstract::Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2005.08.001
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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abstract::The extraction of cortisol from fingernails represents a recent advancement in the retrospective, long-term assessment of hypothalamic-pituitaryadrenal (HPA) axis activity: Fingernail cortisol has the potential to overcome some of the major disadvantages of established HPA axis markers. However, the introduction of an...
journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2017.08.003
更新日期:2017-10-01 00:00:00
abstract::The concept is proposed that polypeptide neurotrophic factors contribute to the developmental regulation of ovarian and hypothalamic function in mammals. Nerve growth factor (NGF) and neurotrophin-3, two members of the neurotrophin family, have been identified in the rat ovary and one of its receptors has been localiz...
journal_title:Frontiers in neuroendocrinology
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