Abstract:
:Endocrine organizational and activational influences on cognitive and affective circuits are likely critical to the development of premenstrual dysphoric disorder (PMDD), a sex-specific hormone-dependent mood disorder. An overview of the anatomical and functional neural characterization of this disorder is presented here by means of neuroimaging correlates, identified from eighteen publications (n = 361 subjects). While white matter integrity remains uninvestigated, greater cerebellar grey matter volume and metabolism were observed in patients with PMDD, along with altered serotonergic and GABAergic neurotransmission. Differential corticolimbic activation in response to emotional stimuli distinguishes the PMDD brain, namely enhanced amygdalar and diminished fronto-cortical function. Thus far, the emotional distress and dysregulation linked to PMDD seem to be defined by structural, chemical and functional brain signatures; however, their characterization remains sparsely studied and somewhat inconsistent. Clear and well-replicated neurobiological features of PMDD are needed to promote timely diagnoses and inform development of prevention and treatment strategies.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Dubol M,Epperson CN,Lanzenberger R,Sundström-Poromaa I,Comasco Edoi
10.1016/j.yfrne.2020.100838subject
Has Abstractpub_date
2020-04-01 00:00:00pages
100838eissn
0091-3022issn
1095-6808pii
S0091-3022(20)30029-7journal_volume
57pub_type
杂志文章,评审abstract::Human models demonstrate that experimental activation of the innate immune system has profound effects on brain activation and behavior, inducing fatigue, worsened mood and pain sensitivity. It has been proposed that inflammation is a mechanism involved in the etiology and maintenance of depression, chronic pain and l...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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abstract::A 37-kDa corticotropin releasing factor (CRF) binding protein (CRF-BP) was purified from human plasma by repeated affinity purification and subsequently sequenced and cloned. The human and rat CRF-BP cDNAs encode proteins of 322 amino acids with one putative signal sequence, one N-glycosylation site, and 10 conserved ...
journal_title:Frontiers in neuroendocrinology
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doi:10.1006/frne.1995.1013
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abstract::Organisms living outside the tropics use changes in photoperiod to adapt to seasonal changes in the environment. Several models have contributed to an understanding of this mechanism at the molecular and endocrine levels. Subtropical birds are excellent models for the study of these mechanisms because of their rapid a...
journal_title:Frontiers in neuroendocrinology
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abstract::Food reward, not hunger, is the main driving force behind eating in the modern obesogenic environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily overconsumed despite the resulting health consequences. Important advances have been made to explain mechanisms underlying excessive co...
journal_title:Frontiers in neuroendocrinology
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abstract::Psychosocial stress, and within the neuroendocrine reaction to stress specifically the glucocorticoid hormones, are well-characterized inhibitors of neural stem/progenitor cell proliferation in the adult hippocampus, resulting in a marked reduction in the production of new neurons in this brain area relevant for learn...
journal_title:Frontiers in neuroendocrinology
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abstract::Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...
journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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abstract::Gene therapy, which entails the use of nucleic acids as drugs, is a new approach to treat disease. Gene therapy has been successfully implemented in several preclinical animal models, including several paradigms of experimental pituitary tumors. In spite of these successes, several critical issues need to be addressed...
journal_title:Frontiers in neuroendocrinology
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doi:10.1016/s0091-3022(02)00106-1
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abstract::The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprintin...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2008.02.002
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abstract::The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1994.1012
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abstract::A majority of birds are socially monogamous, providing exceptional opportunities to discover neuroendocrine mechanisms underlying preferences for opposite-sex partners where the sexes form extended affiliative relationships. Zebra finches have been the focus of the most systematic program of research to date in any so...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.01.003
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.07.003
更新日期:2011-10-01 00:00:00
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2020.100849
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abstract::In addition to its well documented action in female-typical behaviors, progesterone exerts an influence on the brain and behavior of males. This review will discuss the role of progesterone and its receptor in male-typical reproductive behaviors in adulthood and the role of progesterone and its receptor in neural deve...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2006.07.003
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abstract::Identification of novel neurohormones that regulate the reproductive axis is essential for the progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin modulate gonado...
journal_title:Frontiers in neuroendocrinology
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abstract::The maternal microbiota is positioned to regulate the development of offspring immunity, metabolism, as well as brain function and behavior. The mechanisms by which maternal microbial signals drive these processes are beginning to be elucidated. In this review, we provide a brief overview on the importance of the micr...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.100797
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abstract::Appropriate regulatory control of the hypothalamo-pituitary-adrenocortical stress axis is essential to health and survival. The following review documents the principle extrinsic and intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the hypothalamic paraventricular nucleus, which summate...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2003.07.001
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abstract::This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It provides the development of our understanding of the neuroendocrine control of puberty since Harris proposed in his 1955 monograph (Harris, 1955) th...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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abstract::17β-Estradiol (estradiol or E2) is implicated as a neuroprotective factor in a variety of neurodegenerative disorders. This review focuses on the mechanisms underlying E2 neuroprotection in cerebral ischemia, as well as emerging evidence from basic science and clinical studies, which suggests that there is a "critical...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.10.001
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abstract::Lipids are essential for cellular functioning considering their role in membrane composition, signaling, and energy metabolism. The brain is the second most abundant organ in terms of lipid concentration and diversity only after adipose tissue. However, in the central system (CNS) lipid dysregulation has been linked t...
journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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abstract::Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in t...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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abstract::The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:
更新日期:1992-07-01 00:00:00