Abstract：
:Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-mediated effect, and that these may be the primordial glucocorticoid receptors. Although the fast feedback actions of the glucocorticoids enjoyed study in the middle of the last century, new results and the availability of new techniques suggest that it is again time for a concerted effort to be made to understand the mechanism(s) of these rapid effects.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Dallman MFdoi
10.1016/j.yfrne.2005.08.001subject
Has Abstractpub_date
2005-10-01 00:00:00pages
103-8issue
3-4eissn
0091-3022issn
1095-6808pii
S0091-3022(05)00044-0journal_volume
26pub_type
杂志文章,评审abstract：:The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells. The TME emerged as a key modulator of tumour initiation, progression and invasion, with extensive data available in many cancers, but little is ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100852
更新日期：2020-07-01 00:00:00
abstract：:Gene therapy, which entails the use of nucleic acids as drugs, is a new approach to treat disease. Gene therapy has been successfully implemented in several preclinical animal models, including several paradigms of experimental pituitary tumors. In spite of these successes, several critical issues need to be addressed...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/s0091-3022(02)00106-1
更新日期：2003-01-01 00:00:00
abstract：:Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiol...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100768
更新日期：2019-07-01 00:00:00
abstract：:Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,meta分析
doi：10.1016/j.yfrne.2019.100775
更新日期：2019-07-01 00:00:00
abstract：:The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival - are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100766
更新日期：2019-07-01 00:00:00
abstract：:Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also i...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2012.06.002
更新日期：2012-08-01 00:00:00
abstract：:A 37-kDa corticotropin releasing factor (CRF) binding protein (CRF-BP) was purified from human plasma by repeated affinity purification and subsequently sequenced and cloned. The human and rat CRF-BP cDNAs encode proteins of 322 amino acids with one putative signal sequence, one N-glycosylation site, and 10 conserved ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1013
更新日期：1995-10-01 00:00:00
abstract：:Appropriate regulatory control of the hypothalamo-pituitary-adrenocortical stress axis is essential to health and survival. The following review documents the principle extrinsic and intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the hypothalamic paraventricular nucleus, which summate...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2003.07.001
更新日期：2003-07-01 00:00:00
abstract：:Many vertebrates are highly motivated to communicate, suggesting that the consequences of communication may be rewarding. Past studies show that dopamine and opioids in the medial preoptic nucleus (mPOA) and ventral tegmental area (VTA) play distinct roles in motivation and reward. In songbirds, multiple lines of rece...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2012.04.002
更新日期：2012-04-01 00:00:00
abstract：:Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively. Recent studies suggest that these neuropeptides may also signal via each other's receptors. The extent to which such cross-system signali...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.02.001
更新日期：2019-04-01 00:00:00
abstract：:This review examines recent advances in the study of the behavioral responses to deficits of body water and body sodium that in humans are accompanied by the sensations of thirst and salt appetite. Thirst and salt appetite are satisfied by ingesting water and salty substances. These behavioral responses to losses of b...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1997.0153
更新日期：1997-07-01 00:00:00
abstract：:In addition to its well documented action in female-typical behaviors, progesterone exerts an influence on the brain and behavior of males. This review will discuss the role of progesterone and its receptor in male-typical reproductive behaviors in adulthood and the role of progesterone and its receptor in neural deve...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2006.07.003
更新日期：2006-09-01 00:00:00
abstract：:This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It provides the development of our understanding of the neuroendocrine control of puberty since Harris proposed in his 1955 monograph (Harris, 1955) th...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2015.04.002
更新日期：2015-07-01 00:00:00
abstract：:A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1999.0184
更新日期：1999-10-01 00:00:00
abstract：:The majority of songbird species have sexually dimorphic neuronal circuits for song learning and production and these differences are paralleled by sex differences in behavior, with only males singing or singing at a higher rate than females. Therefore songbirds serve as an excellent model for studying the mechanisms ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.11.001
更新日期：2011-01-01 00:00:00
abstract：:Initial investigations into the mechanistic basis of aggression focused on the role of testosterone (T) and a variety of studies on non-human animals found that elevated T levels promote aggression. However, many correlational studies have not detected a significant association between aggression and peripheral T leve...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2005.11.001
更新日期：2006-07-01 00:00:00
abstract：:Human models demonstrate that experimental activation of the innate immune system has profound effects on brain activation and behavior, inducing fatigue, worsened mood and pain sensitivity. It has been proposed that inflammation is a mechanism involved in the etiology and maintenance of depression, chronic pain and l...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2018.06.005
更新日期：2018-07-01 00:00:00
abstract：:Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced ac...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2008.03.001
更新日期：2008-06-01 00:00:00
abstract：:The hippocampus plays an integral role in certain aspects of cognition. Hippocampal structural plasticity and in particular adult hippocampal neurogenesis can be influenced by several intrinsic and extrinsic factors. Here we review how hormones (i.e., intrinsic modulators) and physical exercise (i.e., an extrinsic mod...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2016.03.001
更新日期：2016-04-01 00:00:00
abstract：:Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribu...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2017.12.004
更新日期：2018-07-01 00:00:00
abstract：:Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100815
更新日期：2020-01-01 00:00:00
abstract：:Food reward, not hunger, is the main driving force behind eating in the modern obesogenic environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily overconsumed despite the resulting health consequences. Important advances have been made to explain mechanisms underlying excessive co...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2012.01.002
更新日期：2012-04-01 00:00:00
abstract：:To cope with variations in the environment, most mammalian species exhibit seasonal cycles in physiology and behaviour. Seasonal plasticity during the lifetime contributes to seasonal physiology. Over the years, our ideas regarding adult brain plasticity and, more specifically, hypothalamic plasticity have greatly evo...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2014.11.004
更新日期：2015-04-01 00:00:00
abstract：:This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2014.03.007
更新日期：2014-10-01 00:00:00
abstract：:Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) is the most common mouse model of MS. Treatments with the sex hormones, estrogens and androgens, are capable of offering disease protection during...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.12.001
更新日期：2012-01-01 00:00:00
abstract：:Endocrine organizational and activational influences on cognitive and affective circuits are likely critical to the development of premenstrual dysphoric disorder (PMDD), a sex-specific hormone-dependent mood disorder. An overview of the anatomical and functional neural characterization of this disorder is presented h...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100838
更新日期：2020-04-01 00:00:00
abstract：:Mounting evidence suggests that--beyond the well-known genomic effects--glucocorticoids affect cell function via non-genomic mechanisms. Such mechanisms operate in many major systems and organs including the cardiovascular, immune, endocrine and nervous systems, smooth and skeletal muscles, liver, and fat cells. Non-g...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.10.004
更新日期：2008-05-01 00:00:00
abstract：:The maternal microbiota is positioned to regulate the development of offspring immunity, metabolism, as well as brain function and behavior. The mechanisms by which maternal microbial signals drive these processes are beginning to be elucidated. In this review, we provide a brief overview on the importance of the micr...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100797
更新日期：2019-10-01 00:00:00
abstract：:Neuroscientists are likely to discover new sex differences in the coming years, spurred by the National Institutes of Health initiative to include both sexes in preclinical studies. This review summarizes the current state of knowledge of the cellular and molecular mechanisms underlying sex differences in the mammalia...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2016.01.001
更新日期：2016-01-01 00:00:00
abstract：:In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and b...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/s0091-3022(02)00005-5
更新日期：2002-10-01 00:00:00
