Abstract：
:The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprinting effects upon the morphology of sexually differentiated hypothalamic brain regions, the mechanisms underlying these effects, and their implications in adulthood. Then, I review the evidence that aberrant exposure to hormonally-active substances such as exogenous endocrine-disrupting chemicals (EDCs), may result in improper hypothalamic programming, thereby decreasing reproductive success in adulthood. The field of endocrine disruption has shed new light on the discipline of basic reproductive neuroendocrinology through studies on how early life exposures to EDCs may alter gene expression via non-genomic, epigenetic mechanisms, including DNA methylation and histone acetylation. Importantly, these effects may be transmitted to future generations if the germline is affected via transgenerational, epigenetic actions. By understanding the mechanisms by which natural hormones and xenobiotics affect reproductive neuroendocrine systems, we will gain a better understanding of normal developmental processes, as well as develop the potential ability to intervene when development is disrupted.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Gore ACdoi
10.1016/j.yfrne.2008.02.002subject
Has Abstractpub_date
2008-06-01 00:00:00pages
358-74issue
3eissn
0091-3022issn
1095-6808pii
S0091-3022(08)00006-Xjournal_volume
29pub_type
杂志文章,评审abstract：:Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2013.10.006
更新日期：2014-04-01 00:00:00
abstract：:Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribu...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2017.12.004
更新日期：2018-07-01 00:00:00
abstract：:Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in t...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.03.002
更新日期：2010-07-01 00:00:00
abstract：:Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100849
更新日期：2020-07-01 00:00:00
abstract：:Initial investigations into the mechanistic basis of aggression focused on the role of testosterone (T) and a variety of studies on non-human animals found that elevated T levels promote aggression. However, many correlational studies have not detected a significant association between aggression and peripheral T leve...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2005.11.001
更新日期：2006-07-01 00:00:00
abstract：:The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease (PD) have not yet been clarified, and it is controversial whether there is a critical period for neuroprotection. Studies in animal models and clinical and epidemiological studies indicate that estrogens induce dopaminergic neuroprotecti...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2016.09.003
更新日期：2016-10-01 00:00:00
abstract：:Insight into the mechanisms of action of neurotrophic growth factors has been obtained through the identification and characterization of gene products that are regulated or modified at the transcriptional, translational, and/or posttranslational level in response to neurotrophin treatment. VGF (non-acronymic) was ide...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.2000.0199
更新日期：2000-07-01 00:00:00
abstract：:Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.09.001
更新日期：2008-05-01 00:00:00
abstract：:Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1996.0013
更新日期：1996-10-01 00:00:00
abstract：:Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) is the most common mouse model of MS. Treatments with the sex hormones, estrogens and androgens, are capable of offering disease protection during...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.12.001
更新日期：2012-01-01 00:00:00
abstract：:The extraction of cortisol from fingernails represents a recent advancement in the retrospective, long-term assessment of hypothalamic-pituitaryadrenal (HPA) axis activity: Fingernail cortisol has the potential to overcome some of the major disadvantages of established HPA axis markers. However, the introduction of an...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2020.100855
更新日期：2020-07-01 00:00:00
abstract：:In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2006.09.004
更新日期：2006-12-01 00:00:00
abstract：:Alcohol stimulates the hypothalamic-pituitary-adrenal (HPA) axis through brain-based mechanisms in which endogenous corticotropin-releasing factor (CRF) plays a major role. This review first discusses the evidence for this role, as well as the possible importance of intermediates such as vasopressin, nitric oxide and ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2013.10.005
更新日期：2014-04-01 00:00:00
abstract：:Female sexual behavior in rodents, typified by the lordosis posture, is hormone-dependent and sex-specific. Ovarian hormones control this behavior via receptors in the hypothalamic ventromedial nucleus (VMH). This review considers the sex differences in the morphology, neurochemistry and neural circuitry of the VMH to...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.02.008
更新日期：2011-04-01 00:00:00
abstract：:A 37-kDa corticotropin releasing factor (CRF) binding protein (CRF-BP) was purified from human plasma by repeated affinity purification and subsequently sequenced and cloned. The human and rat CRF-BP cDNAs encode proteins of 322 amino acids with one putative signal sequence, one N-glycosylation site, and 10 conserved ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1013
更新日期：1995-10-01 00:00:00
abstract：:Trans-generational epigenetic phenomena, such as contamination with endocrine-disrupting chemicals (EDCs) that decrease fertility and the global methylation status of DNA in the offspring, are of great concern because they may affect health, particularly the health of children. However, of even greater concern is the ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2007.12.004
更新日期：2008-06-01 00:00:00
abstract：:A majority of birds are socially monogamous, providing exceptional opportunities to discover neuroendocrine mechanisms underlying preferences for opposite-sex partners where the sexes form extended affiliative relationships. Zebra finches have been the focus of the most systematic program of research to date in any so...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.01.003
更新日期：2011-04-01 00:00:00
abstract：:Many vertebrates are highly motivated to communicate, suggesting that the consequences of communication may be rewarding. Past studies show that dopamine and opioids in the medial preoptic nucleus (mPOA) and ventral tegmental area (VTA) play distinct roles in motivation and reward. In songbirds, multiple lines of rece...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2012.04.002
更新日期：2012-04-01 00:00:00
abstract：:Most human obesity is inherited as a polygenic trait which is largely refractory to medical therapy because obese individuals avidly defend their elevated body weight set-point. This set-point is mediated by an integrated neural network that controls energy homeostasis. Epidemiological studies suggest that perinatal a...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2010.02.005
更新日期：2010-07-01 00:00:00
abstract：:The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2011.07.003
更新日期：2011-10-01 00:00:00
abstract：:In addition to its well documented action in female-typical behaviors, progesterone exerts an influence on the brain and behavior of males. This review will discuss the role of progesterone and its receptor in male-typical reproductive behaviors in adulthood and the role of progesterone and its receptor in neural deve...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2006.07.003
更新日期：2006-09-01 00:00:00
abstract：:Gene therapy, which entails the use of nucleic acids as drugs, is a new approach to treat disease. Gene therapy has been successfully implemented in several preclinical animal models, including several paradigms of experimental pituitary tumors. In spite of these successes, several critical issues need to be addressed...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/s0091-3022(02)00106-1
更新日期：2003-01-01 00:00:00
abstract：:A rapidly growing body of evidence reveals that complex networks of communication exist between the neuroendocrine and the immune systems. Essential to the maintenance and function of the immune-endocrine circuitry are an array of chemical mediators produced by cells of the immune and endocrine systems. Cytokines are ...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1001
更新日期：1995-01-01 00:00:00
abstract：:Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiol...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2019.100768
更新日期：2019-07-01 00:00:00
abstract：:Appropriate regulatory control of the hypothalamo-pituitary-adrenocortical stress axis is essential to health and survival. The following review documents the principle extrinsic and intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the hypothalamic paraventricular nucleus, which summate...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2003.07.001
更新日期：2003-07-01 00:00:00
abstract：:Attention Deficit Hyperactivity Disorder (ADHD) is a developmental condition characterised by severe inattention, pathological impulsivity and hyperactivity; it is relatively common affecting up to 6% of children, and is associated with a risk of long-term adverse educational and social consequences. Males are conside...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2014.03.003
更新日期：2014-08-01 00:00:00
abstract：:The immune system and the hypothalamic-pituitary (H-P) axis are functionally connected, so that exposure to antigens elicits a coordinated response which allows the organism to successfully withstand immunologic challenges. An important feature of this bilateral communication is the appearance of proteins released int...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1995.1005
更新日期：1995-04-01 00:00:00
abstract：:Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2005.08.001
更新日期：2005-10-01 00:00:00
abstract：:Parental care is found widely across animal taxa and is manifest in a range of behaviours from basic provisioning in cockroaches to highly complex behaviours seen in mammals. The evolution of parental care is viewed as the outcome of an evolutionary cost/benefit trade-off between investing in current and future offspr...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.yfrne.2018.12.004
更新日期：2019-01-01 00:00:00
abstract：:Clinical introduction of octreotide, a long-acting somatostatin analog, has opened a new era in the medical therapy of patients with growth hormone (GH)- and thyroid-stimulating hormone (TSH)-secreting pituitary tumors. Good control of hormonal hypersecretion occurred in most patients, and tumor shrinkage has been obs...
journal_title：Frontiers in neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1006/frne.1993.1002
更新日期：1993-01-01 00:00:00
