Abstract:
:Clinical introduction of octreotide, a long-acting somatostatin analog, has opened a new era in the medical therapy of patients with growth hormone (GH)- and thyroid-stimulating hormone (TSH)-secreting pituitary tumors. Good control of hormonal hypersecretion occurred in most patients, and tumor shrinkage has been observed in more than half of them. Octreotide therapy is of no value in most patients with Prolactin (PRL)- and adrenocorticotrophic (ACTH)-secreting pituitary tumors. However patients with Cushing's syndrome caused by ectopic ACTH secretion from a variety of endocrine tumors benefit from octreotide administration. In patients with visual disturbances related to chiasmal compression by nonfunctioning pituitary tumors, somatostatin analog administration has been reported to result in rapid improvement in visual acuity. This beneficial effect might not be related to a direct action of octreotide, but may reflect an effect on the retina and/or optic nerve. The presence of somatostatin receptors on a wide variety of pituitary tumors as well as on a number of parasellar tumors allows their in vivo visualization with radionucleotide-labelled somatostatin analogs. A positive scan in patients with GH- and TSH-secreting pituitary tumors is predictive of a good suppressive effect of octreotide on hormone release by these tumors. PRL- and ACTH-secreting pituitary adenomas cannot be visualized, but clinically nonfunctioning pituitary adenomas are visualized in 75% of cases with 111In-DTPA-octreotide. At present it is unclear whether this has consequences with regard to the medical treatment of these last group of patients. Somatostatin receptor scintigraphy can be successfully used in the differential diagnosis between pituitary hypersecretion of GH and/or ACTH and the ectopic secretion of growth hormone-releasing hormone (GHRH) and ACTH by peripherally localized endocrine tumors. Again the visualization of such tumors also predicts successful control of hormonal hypersecretion by octreotide.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Lamberts SW,Hofland LJ,de Herder WW,Kwekkeboom DJ,Reubi JC,Krenning EPdoi
10.1006/frne.1993.1002subject
Has Abstractpub_date
1993-01-01 00:00:00pages
27-55issue
1eissn
0091-3022issn
1095-6808pii
S0091302283710022journal_volume
14pub_type
杂志文章,评审abstract::Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced ac...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2008.03.001
更新日期:2008-06-01 00:00:00
abstract::Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2007.09.001
更新日期:2008-05-01 00:00:00
abstract::In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and b...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/s0091-3022(02)00005-5
更新日期:2002-10-01 00:00:00
abstract::Female sexual behavior in rodents, typified by the lordosis posture, is hormone-dependent and sex-specific. Ovarian hormones control this behavior via receptors in the hypothalamic ventromedial nucleus (VMH). This review considers the sex differences in the morphology, neurochemistry and neural circuitry of the VMH to...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.02.008
更新日期:2011-04-01 00:00:00
abstract::A 37-kDa corticotropin releasing factor (CRF) binding protein (CRF-BP) was purified from human plasma by repeated affinity purification and subsequently sequenced and cloned. The human and rat CRF-BP cDNAs encode proteins of 322 amino acids with one putative signal sequence, one N-glycosylation site, and 10 conserved ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1013
更新日期:1995-10-01 00:00:00
abstract::The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:
更新日期:1992-07-01 00:00:00
abstract::Psychosocial stress, and within the neuroendocrine reaction to stress specifically the glucocorticoid hormones, are well-characterized inhibitors of neural stem/progenitor cell proliferation in the adult hippocampus, resulting in a marked reduction in the production of new neurons in this brain area relevant for learn...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.05.001
更新日期:2016-04-01 00:00:00
abstract::The extraction of cortisol from fingernails represents a recent advancement in the retrospective, long-term assessment of hypothalamic-pituitaryadrenal (HPA) axis activity: Fingernail cortisol has the potential to overcome some of the major disadvantages of established HPA axis markers. However, the introduction of an...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2020.100855
更新日期:2020-07-01 00:00:00
abstract::Many vertebrates are highly motivated to communicate, suggesting that the consequences of communication may be rewarding. Past studies show that dopamine and opioids in the medial preoptic nucleus (mPOA) and ventral tegmental area (VTA) play distinct roles in motivation and reward. In songbirds, multiple lines of rece...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2012.04.002
更新日期:2012-04-01 00:00:00
abstract::The majority of songbird species have sexually dimorphic neuronal circuits for song learning and production and these differences are paralleled by sex differences in behavior, with only males singing or singing at a higher rate than females. Therefore songbirds serve as an excellent model for studying the mechanisms ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2010.11.001
更新日期:2011-01-01 00:00:00
abstract::Developmental studies of hormones and behavior often include littermates-rodent siblings that share early-life experiences and genes. Due to between-litter variation (i.e., litter effects), the statistical assumption of independent observations is untenable. In two literatures-natural variation in maternal care and pr...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2017.08.003
更新日期:2017-10-01 00:00:00
abstract::Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiol...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.100768
更新日期:2019-07-01 00:00:00
abstract::A rapidly growing body of evidence reveals that complex networks of communication exist between the neuroendocrine and the immune systems. Essential to the maintenance and function of the immune-endocrine circuitry are an array of chemical mediators produced by cells of the immune and endocrine systems. Cytokines are ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1995.1001
更新日期:1995-01-01 00:00:00
abstract::Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2005.08.001
更新日期:2005-10-01 00:00:00
abstract::Studies on endogenous oxytocin concentrations are often criticized for the debatable comparability between specimens and the variation in reported values. We performed meta-regressions on k = 229 studies (n = 12 741 participants), testing whether specimen, extraction, sex, age, time of day, or fasting instructions inf...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,meta分析
doi:10.1016/j.yfrne.2019.100775
更新日期:2019-07-01 00:00:00
abstract::Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2017.08.001
更新日期:2017-10-01 00:00:00
abstract::A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1999.0184
更新日期:1999-10-01 00:00:00
abstract::Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1996.0013
更新日期:1996-10-01 00:00:00
abstract::The maternal microbiota is positioned to regulate the development of offspring immunity, metabolism, as well as brain function and behavior. The mechanisms by which maternal microbial signals drive these processes are beginning to be elucidated. In this review, we provide a brief overview on the importance of the micr...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.100797
更新日期:2019-10-01 00:00:00
abstract::The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival - are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2019.100766
更新日期:2019-07-01 00:00:00
abstract::The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1006/frne.1994.1012
更新日期:1994-12-01 00:00:00
abstract::Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation of animal studies demonstrating the vital role for ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2020.100849
更新日期:2020-07-01 00:00:00
abstract::A majority of birds are socially monogamous, providing exceptional opportunities to discover neuroendocrine mechanisms underlying preferences for opposite-sex partners where the sexes form extended affiliative relationships. Zebra finches have been the focus of the most systematic program of research to date in any so...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.01.003
更新日期:2011-04-01 00:00:00
abstract::Alcohol stimulates the hypothalamic-pituitary-adrenal (HPA) axis through brain-based mechanisms in which endogenous corticotropin-releasing factor (CRF) plays a major role. This review first discusses the evidence for this role, as well as the possible importance of intermediates such as vasopressin, nitric oxide and ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2013.10.005
更新日期:2014-04-01 00:00:00
abstract::Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2013.10.006
更新日期:2014-04-01 00:00:00
abstract::The hippocampus plays an integral role in certain aspects of cognition. Hippocampal structural plasticity and in particular adult hippocampal neurogenesis can be influenced by several intrinsic and extrinsic factors. Here we review how hormones (i.e., intrinsic modulators) and physical exercise (i.e., an extrinsic mod...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.03.001
更新日期:2016-04-01 00:00:00
abstract::The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2011.07.003
更新日期:2011-10-01 00:00:00
abstract::Neuroscientists are likely to discover new sex differences in the coming years, spurred by the National Institutes of Health initiative to include both sexes in preclinical studies. This review summarizes the current state of knowledge of the cellular and molecular mechanisms underlying sex differences in the mammalia...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.01.001
更新日期:2016-01-01 00:00:00
abstract::The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease (PD) have not yet been clarified, and it is controversial whether there is a critical period for neuroprotection. Studies in animal models and clinical and epidemiological studies indicate that estrogens induce dopaminergic neuroprotecti...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2016.09.003
更新日期:2016-10-01 00:00:00
abstract::Trans-generational epigenetic phenomena, such as contamination with endocrine-disrupting chemicals (EDCs) that decrease fertility and the global methylation status of DNA in the offspring, are of great concern because they may affect health, particularly the health of children. However, of even greater concern is the ...
journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.yfrne.2007.12.004
更新日期:2008-06-01 00:00:00