Abstract：
:The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival - are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of which the primary objective is to mitigate addiction-related stress. The aim of this review is to synthesize current information specific to pregnancy and parenting that may be affected by OUD. We first summarize a model of the parental brain supported by animal research and human neuroimaging. We then review animal models of exogenous opioid effects on parental brain and behavior. We also present preliminary data for a unifying hypothesis that may link different effects of exogenous opioids on parenting across species and in the context of OMT. Finally, we discuss future directions that may inform research and clinical decision making for peripartum women with OUD.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Swain JE,Ho SS,Fox H,Garry D,Brummelte Sdoi
10.1016/j.yfrne.2019.100766subject
Has Abstractpub_date
2019-07-01 00:00:00pages
100766eissn
0091-3022issn
1095-6808pii
S0091-3022(18)30130-4journal_volume
54pub_type
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