Abstract:
:Food reward, not hunger, is the main driving force behind eating in the modern obesogenic environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily overconsumed despite the resulting health consequences. Important advances have been made to explain mechanisms underlying excessive consumption as an immediate response to presentation of rewarding tastants. However, our understanding of long-term neural adaptations to food reward that oftentimes persist during even a prolonged absence of palatable food and contribute to the reinstatement of compulsive overeating of high-fat high-sugar diets, is much more limited. Here we discuss the evidence from animal and human studies for neural and molecular adaptations in both homeostatic and non-homeostatic appetite regulation that may underlie the formation of a "feed-forward" system, sensitive to palatable food and propelling the individual from a basic preference for palatable diets to food craving and compulsive, addiction-like eating behavior.
journal_name
Front Neuroendocrinoljournal_title
Frontiers in neuroendocrinologyauthors
Alsiö J,Olszewski PK,Levine AS,Schiöth HBdoi
10.1016/j.yfrne.2012.01.002subject
Has Abstractpub_date
2012-04-01 00:00:00pages
127-39issue
2eissn
0091-3022issn
1095-6808pii
S0091-3022(12)00003-9journal_volume
33pub_type
杂志文章,评审abstract::In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...
journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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journal_title:Frontiers in neuroendocrinology
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