Abstract：
:Detergent-unextractable structures of synaptic plasma membrane of rat cerebrum were observed by whole mount electron microscopy. The globular structures were identified as postsynaptic densities (PSDs) from several criteria and appeared to consist of folded strings, to which a number of other molecules might be attached. Some of the globular structures were attached with subsynaptic webs. The structures contained a number of finely striated small strips (10-20 nm wide, 60-100 nm long), parts of which were peeled off from PSD cytoskeletal base by N-lauroyl sarcosinate.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Suzuki T,Tanaka Rdoi
10.1016/0168-0102(86)90004-0subject
Has Abstractpub_date
1986-02-01 00:00:00pages
226-36issue
3eissn
0168-0102issn
1872-8111pii
0168-0102(86)90004-0journal_volume
3pub_type
杂志文章abstract：:The cranial nerves and the brain fiber systems of the medaka (Oryzias latipes) fry are revealed by a whole-mount staining method. Newly hatched fry of an albino strain of the medaka were fixed, partially digested with trypsin, treated in 1% Triton X-100, and finally immunohistochemically stained using anti-neurofilame...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90079-5
更新日期：1994-06-01 00:00:00
abstract：:This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00245-0
更新日期：2001-08-01 00:00:00
abstract：:Bacterial lipopolysaccharide (LPS) is a major component of the cell wall of gram negative bacteria contributing to the pathogenesis of bacterial infection, in particular in those diseases affecting central nervous system and reproductive tissues. The present work is an attempt to study the regulation of steroidogenic ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.02.011
更新日期：2014-06-01 00:00:00
abstract：:The distribution of neurofilament proteins and peripherin in the pituitary gland of the rat was studied with a panel of monoclonal and polyclonal antibodies recognizing different neurofilament subunits. In the posterior lobe, a dense plexus of neurofilament- and peripherin-immunoreactive fibers was seen. In the interm...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00903-7
更新日期：1995-06-01 00:00:00
abstract：:Ethanol's actions in brain have been suggested to be partially mediated by a mechanism involving the ethanol-induced activation of the endogenous opioid system. Opioid systems, which are closely linked with dopamine transmission, are thought to be affected by ethanol through alterations in the processing, release, and...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00188-3
更新日期：2003-10-01 00:00:00
abstract：:To elucidate biophysical mechanisms underlying the Zn2+ block on the low-threshold T-type Ca2+ current (I(T)), we examined the Zn(2+)-induced alterations of gating properties of I(T) of a rat thalamic relay neuron and of alpha1G channels expressed in HEK-293 cells, using a whole-cell voltage clamp technique. The effec...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.12.005
更新日期：2010-04-01 00:00:00
abstract：:Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie con...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2019.10.002
更新日期：2020-07-01 00:00:00
abstract：:Diazepam binding inhibitor (DBI), a putative endogenous polypeptide ligand for benzodiazepine (BZD) receptors, has been shown to act as an inverse BZD receptor agonist in the brain. We previously suggested that the social isolation stress-induced decrease in pentobarbital sleeping time in mice was partly due to an inc...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00010-3
更新日期：1999-03-01 00:00:00
abstract：:L-glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system and has also been implicated as a potent neurotoxin. To ensure a high signal-to-noise ratio during synaptic transmission and to prevent neuronal damage that might occur as a result of excessive activation of glutamate recept...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/s0168-0102(00)00104-8
更新日期：2000-05-01 00:00:00
abstract：:The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was gi...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00063-9
更新日期：2002-08-01 00:00:00
abstract：:To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus fol...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.11.007
更新日期：2007-03-01 00:00:00
abstract：:The magnitude of long-term potentiation (LTP) was re-examined for monosynaptic transmission between mossy fibers and CA3 neurons in thin sections of the hippocampus of the guinea pig. Although an initial negative deflection in the field potential showed apparent short-term potentiation, this deflection was concluded t...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(86)90060-x
更新日期：1986-09-01 00:00:00
abstract：:To investigate how motor programs can be modified by sensory inputs we recorded kinematic and EMG patterns from normal human subjects performing well-practised wrist flexion movements in response to an auditory tone. On random trials unexpected wrist perturbations were introduced at varying times after the signal to m...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90062-j
更新日期：1990-06-01 00:00:00
abstract：:Visual-spatial navigation in familiar and unfamiliar environments is an essential requirement of daily life. Animal studies indicated the importance of the hippocampus for navigation. Neuroimaging studies demonstrated gender difference or strategies dependent difference of neural substrates for navigation. Using funct...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.04.009
更新日期：2006-08-01 00:00:00
abstract：:Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal lev...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.12.018
更新日期：2011-04-01 00:00:00
abstract：:The NRG1 growth factor and ERBB4 receptor have been identified as leading schizophrenia risk genes. Although NRG1 and ERBB4 have been shown to modulate neuronal functions involved in schizophrenia, including both GABAergic and glutamatergic synapses, the exact molecular mechanisms remain poorly understood. Here we inv...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.02.009
更新日期：2011-06-01 00:00:00
abstract：:Glutamate receptor subtypes mediating excitatory synaptic neurotransmission in the cerebellar cortex are briefly reviewed from molecular biological, electrophysiological and pharmacological points of view. In particular, molecular biological findings of a novel family of AMPA-selective glutamate receptors are introduc...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(91)90023-r
更新日期：1991-01-01 00:00:00
abstract：:Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90081-z
更新日期：1993-02-01 00:00:00
abstract：:Hippocampal neurogenesis is influenced by many factors. In this study, we examined the effect of tactile stimulation (tickling), which induced positive emotion, on neurogenesis in the dentate gyrus (DG) of the hippocampus. Four week-old rats were tickled for 5 min/day on 5 consecutive days and received 5-bromo-2'-deox...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.09.001
更新日期：2010-12-01 00:00:00
abstract：:The role of cholinergic basal forebrain inputs to cerebral cortex in regulating regional nerve growth factor (NGF) secretion was examined in adult (4-6 months) and aged (29-31 months) rats. Halothane-anesthetized rats received unilateral electrical stimulation of the nucleus basalis of Meynert (NBM). NGF levels were m...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.11.004
更新日期：2009-02-01 00:00:00
abstract：:We have generated a transgenic mouse model in which astrocytes express an enhanced green fluorescent protein (EGFP) under the control of the mouse glial fibrillary acidic protein (GFAP) promoter. EGFP, which is characteristically found throughout the cell, was expressed in these animals even in astrocytic fine process...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.08.008
更新日期：2003-12-01 00:00:00
abstract：:The Approach-Avoidance Task (AAT) measures automatic approach-avoidance tendencies and their regulation: compatible reactions (approach positive, avoid negative) are faster than incompatible ones (approach negative, avoid positive). The present study assessed event-related potentials (ERPs) in 15 healthy persons for d...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.12.005
更新日期：2013-03-01 00:00:00
abstract：:Temporal changes in kainate-induced seizure activity and hippocampal NO generation were evaluated simultaneously in conscious rats by using in vivo microdialysis and by determining the concentrations of nitrite and nitrate in perfusates. Intraperitoneal injection of kainic acid produced 'wet dog shake', focal seizure ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00086-8
更新日期：1998-11-01 00:00:00
abstract：:Alcoholism is a psychiatric condition that develops through neuroadaptations in response to neuronal stresses caused by chronic ethanol intake. Neurons can adapt to ethanol-induced metabolic changes by activating cellular protective mechanisms, including autophagy. Here we show that expression of Ulk1, a gene critical...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.12.004
更新日期：2017-04-01 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-beta superfamily and acts as a neurotrophic factor for the nigrostriatal dopamine (DA) system. Although previous studies have shown that pretreatment with GDNF could prevent degenerative changes of nigrostriatal DA system ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00097-3
更新日期：2000-04-01 00:00:00
abstract：:Contradictory data on behavioral changes in MPTP-treated C57BL/6 mice have been reported, even though the toxin-treated mice have been widely used for non-clinical studies as an in vivo model of Parkinson's disease (PD). We found that the duration of immobility in the tail suspension test (TST) was significantly incre...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.11.008
更新日期：2005-03-01 00:00:00
abstract：:The effects of 5-HT3-receptor-related agents on long-term potentiation (LTP) in the mossy fiber-CA3 system were studied in guinea pig hippocampal slices. 5-HT3 receptor agonists, 1-(m-chlorophenyl)-biguanide (mCPBG) and 2-methyl serotonin (2-Me-5-HT) significantly attenuated the magnitude of LTP of the population spik...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90163-5
更新日期：1994-01-01 00:00:00
abstract：:During development, neurons migrate from their origin to their final destinations where they form neuronal architectures such as layers and nuclei. While the mechanisms for the formation of laminated structures have been studied extensively, little is known about nucleogenesis. Previously, we analyzed nucleogenesis in...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.01.007
更新日期：2009-05-01 00:00:00
abstract：:In the rat striatum numerous secretagogin (SCGN) positive neurons were scattered. They were heterogeneous in their morphological and chemical properties. We examined the colocalization of SCGN with known four interneuron markers, parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and choline acetyl transfe...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.01.004
更新日期：2017-06-01 00:00:00
abstract：:Given the amygdala's role in survival mechanisms, and its pivotal contributions to psychological processes, it is no surprise that it is one of the most well-studied brain regions. One of the common methods for understanding the functional role of the amygdala is the use of functional magnetic resonance imaging (fMRI)...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.01.009
更新日期：2020-01-01 00:00:00
