Abstract:
:Glutamate receptor subtypes mediating excitatory synaptic neurotransmission in the cerebellar cortex are briefly reviewed from molecular biological, electrophysiological and pharmacological points of view. In particular, molecular biological findings of a novel family of AMPA-selective glutamate receptors are introduced, and the pharmacological and electrophysiological properties and the identity of cerebellar N-methyl-D-aspartate-sensitive receptors probably existing on Purkinje cells are discussed in comparison with well-established cerebral NMDA receptors. As possible intracellular mechanisms of the long-term depression of parallel fiber-Purkinje cell neurotransmission, the perspective of the roles of novel messengers, nitric oxide and arachidonic acid, is particularly commented based on recent information about cerebral long-term events. The specificity and possible independence of cerebellar excitatory amino acid receptors and linked intracellular second messengers are also suggested, taking the highly active guanylate cyclase system in Purkinje cells and other cerebellum-specific proteins into consideration.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Okamoto K,Sekiguchi Mdoi
10.1016/0168-0102(91)90023-rsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
213-37issue
4eissn
0168-0102issn
1872-8111pii
0168-0102(91)90023-Rjournal_volume
9pub_type
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