Abstract:
:Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie context-dependence. Input summation and output normalization are mediated by input-output relationships in canonical microcircuits (CM). DN/CM are altered in psychiatric disorders like schizophrenia or depression whose various symptoms can be characterized by abnormal context-dependence.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Northoff G,Mushiake Hdoi
10.1016/j.neures.2019.10.002subject
Has Abstractpub_date
2020-07-01 00:00:00pages
130-140eissn
0168-0102issn
1872-8111pii
S0168-0102(19)30536-Xjournal_volume
156pub_type
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