Stress by noise produces differential effects on the proliferation rate of radial astrocytes and survival of neuroblasts in the adult subgranular zone.

Abstract:

:The subgranular zone (SGZ) in the dentate gyrus contains radial astrocytes, known as Type-1 or Type-B cells, which generate neuroblasts (Type-2 cells or Type-D cells) that give rise to granular neurons. Stress increases glucocorticoid levels that target SGZ and modify the proliferation and apoptosis of hippocampal cells. Yet, it is not well-known whether stress differentially affects SGZ progenitors. We investigated the effects of noise-induced stress on the rate of proliferation and apoptosis of the Type-1 cells, Type-2 cells and newly generated granular neurons in the SGZ. We exposed Balb/C mice to noise using a standardized rodents' audiogram-fitted adaptation of a human noisy environment. We measured corticosterone serum levels at different time points. Animals received BrdU injections for 3 days and sequential sacrifices were done to carry out double-immunohistochemical analyses. We found that a 24-h noise exposure did not produce adaptative response in the curve of corticosterone as compared to a 12-h noise exposure. The percentage of BrdU+/GFAP+ cells was significantly reduced in the stress group as compared to controls. A high proportion of CASP-3+/GFAP+ radial astrocytes were found in the stress group. The percentage of BrdU+/doublecortin+ cells was higher in controls than in the stress group. Interestingly, the apoptosis rate of doublecortin-expressing cells in the stress group was slightly lesser than in controls. Remarkably, we did not find significant differences in the number of BrdU+/NeuN+ and CASP-3+/NeuN+ neurons. These data indicate that stress differentially affects the rate of proliferation and apoptosis in SGZ progenitors and suggest a possible compensatory mechanism to keep the net number of granular neurons.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Gonzalez-Perez O,Chavez-Casillas O,Jauregui-Huerta F,Lopez-Virgen V,Guzman-Muniz J,Moy-Lopez N,Gonzalez-Castaneda RE,Luquin S

doi

10.1016/j.neures.2011.03.013

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

243-50

issue

3

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(11)00101-5

journal_volume

70

pub_type

杂志文章
  • Change in phase synchronization of local field potentials in anesthetized rats after chronic dopamine depletion.

    abstract::In order to investigate temporal characteristics of oscillatory neural activity and the effect of chronic dopamine depletion on it, local field potentials were measured in anesthetized rats without or with a 6-OHDA lesion at either the ventral tegmental area or the substantia nigra compacta, using a pair of electrodes...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2004.02.008

    authors: Lee KM,Ahn TB,Jeon BS,Kim DG

    更新日期:2004-06-01 00:00:00

  • Functional roles of the superior laryngeal nerve afferents in electrically induced vocalization in anesthetized cats.

    abstract::Our purpose was to elucidate the functional roles of the laryngeal afferents in controlling vocalization. We investigated the effects of laryngeal deafferentation (sectioning the internal branch of the superior laryngeal nerve (ISLN)) on respiration and voice quality during electrically-induced vocalization in twelve ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(95)00877-v

    authors: Shiba K,Yoshida K,Miura T

    更新日期:1995-03-01 00:00:00

  • Immunohistochemical study on the neuronal diversity and three-dimensional organization of the mouse entopeduncular nucleus.

    abstract::The entopeduncular nucleus (EPN) is one of the major output nuclei of the basal ganglia in rodents. Previous studies have divided it into rostral and caudal halves, with the former containing somatostatin (SOM)-immunoreactive neurons and the latter dominated by parvalbumin (PV)-containing neurons, respectively. Howeve...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2015.02.006

    authors: Miyamoto Y,Fukuda T

    更新日期:2015-05-01 00:00:00

  • Do pontocerebellar mossy fibres give off collaterals to the cerebellar nuclei? An experimental study in the cat with implantation of crystalline HRP-WGA.

    abstract::In 15 cats with implantations of crystalline HRP-WGA in the cerebellar nuclei and tetramethylbenzidine histochemistry, the pontine nuclei were carefully examined for presence of retrogradely labelled cells. Findings in the nucleus reticularis tegmenti pontis and the inferior olive, both known to project to the cerebel...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(86)90013-1

    authors: Brodal P,Dietrichs E,Walberg F

    更新日期:1986-11-01 00:00:00

  • Somatic noxious mechanical stimulation induces Fos expression in the postsynaptic dorsal column neurons in laminae III and IV of the rat spinal dorsal horn.

    abstract::This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(01)00245-0

    authors: Day AS,Wen CY,Shieh JY,Sun WZ,Lue JH

    更新日期:2001-08-01 00:00:00

  • Activity in receptor afferents from the anterior cruciate ligament evokes reflex effects on fusimotor neurones.

    abstract::Responses from 2-4 muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles were simultaneously recorded in cats anaesthetized with alpha-chloralose. It was demonstrated that stretch of the anterior cruciate ligament (ACL) of the ipsilateral knee causes changes in dynamic and/or s...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(90)90057-l

    authors: Johansson H,Sjölander P,Sojka P

    更新日期:1990-04-01 00:00:00

  • Concept and molecular basis of axonal regeneration after central nervous system injury.

    abstract::Damage to the central nervous system (CNS) leads to the disruption of the axonal network and causes neurological dysfunction. Recovery of neurological functions requires restoration of the axonal network; however, injured axons in the adult mammalian CNS rarely regenerate after injury. Failure of the injured axon to r...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2013.07.002

    authors: Muramatsu R,Yamashita T

    更新日期:2014-01-01 00:00:00

  • Ingroup favoritism or the black sheep effect: Perceived intentions modulate subjective responses to aggressive interactions.

    abstract::Social categorization plays an important role in provoking the victim's responses to aggressive interactions. Pioneering studies suggested that uncertainty in the perpetrator's hostile intention influences whether ingroup favoritism or the black sheep effect (ingroup strictness) will be manifested to a greater extent....

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2016.01.011

    authors: Wang L,Zheng J,Meng L,Lu Q,Ma Q

    更新日期:2016-07-01 00:00:00

  • Interaction between nitric oxide and substance P on heat-induced inflammation in rat paw.

    abstract::To elucidate the interaction between nitric oxide (NO) and substance P (SP) in neurogenic inflammatory responses, we measured the change in the degree of Evans blue leakage and NO levels in perfusate from the subcutaneous space in the rat instep following noxious heat stimulation (47 degrees C for 30 min). Furthermore...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(99)00107-8

    authors: Yonehara N,Yoshimura M

    更新日期:2000-01-01 00:00:00

  • Regulation of cortical blood flow responses by the nucleus basalis of Meynert during nociceptive processing.

    abstract::Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in system...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2019.01.008

    authors: Paquette T,Tokunaga R,Touj S,Leblond H,Piché M

    更新日期:2019-12-01 00:00:00

  • Cell death mechanisms in the early stages of acute glutamate neurotoxicity.

    abstract::The present study focused on the early stages of acute glutamate (L-Glu)-induced neurotoxic mechanisms, both biochemical, e.g. intracellular reactive oxygen species (ROS) and associated parameters as well as gene expression of cell survival/death pathways, i.e. Bcl-2 and caspases. Stereotactic intracortical injections...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.11.009

    authors: Kumar A,Singh RL,Babu GN

    更新日期:2010-03-01 00:00:00

  • Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats.

    abstract::There is an endocrinological concern that environmental endocrine disrupters (EEDs) may influence sexual differentiation. Bisphenol A (BPA), one of EEDs, is released from polycarbonate plastics, and has been detected in the human umbilical cord. In this study, we examined the effect of BPA on the sexual differentiatio...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(02)00251-1

    authors: Kubo K,Arai O,Omura M,Watanabe R,Ogata R,Aou S

    更新日期:2003-03-01 00:00:00

  • Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system.

    abstract::Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Chicken Bsg (HT7/neurothelin/ 5A11) is expressed in neuroblasts, but disappears from neurons after a specific stage of cytodifferentiation, and becomes restrictedly expressed in the capillary endothelium in the adult brain. We s...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)00119-3

    authors: Fan QW,Yuasa S,Kuno N,Senda T,Kobayashi M,Muramatsu T,Kadomatsu K

    更新日期:1998-01-01 00:00:00

  • Corticotropin releasing factor and galanin-containing neurons projecting to the median eminence of the rat.

    abstract::To identify corticotropin releasing factor (CRF)- and galanin (GAL)-containing neurons projecting to the median eminence, a retrograde tracing method with True blue was combined with a double-staining method. It was demonstrated that some True blue-labeled CRF neurons in the paraventricular nucleus were also immunorea...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(92)90073-l

    authors: Niimi M,Takahara J,Kawanishi K

    更新日期:1992-09-01 00:00:00

  • Real time analysis of pontine neurons during initial stages of nucleogenesis.

    abstract::During development, neurons migrate from their origin to their final destinations where they form neuronal architectures such as layers and nuclei. While the mechanisms for the formation of laminated structures have been studied extensively, little is known about nucleogenesis. Previously, we analyzed nucleogenesis in...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.01.007

    authors: Watanabe H,Murakami F

    更新日期:2009-05-01 00:00:00

  • Membrane properties of rat medial vestibular nucleus neurons in vivo.

    abstract::In our previous study using the whole-cell patch clamp technique combined with reverse transcription-polymerase chain reaction analysis in rat brainstem slices, we demonstrated that the classification of neurons in the medial vestibular nucleus (MVN) based on three membrane properties detected as voltage response prop...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2007.06.1479

    authors: Saito Y,Ozawa S

    更新日期:2007-10-01 00:00:00

  • Neuronal connections between the auricular skin and the sympathetic pre- and postganglionic neurons of the dog as studied by using pseudorabies virus.

    abstract::Pseudorabies virus (PrV) as a neuronal tracer was microinjected into the concave surface of the puppy's left pinna to establish the morphological basis of somato-visceral linkage. The virus infected neurons were detected by FITC conjugated with polyclonal swine anti-PrV serum. Labelled neurons were localized in: (1) t...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)00129-6

    authors: Chien CH,Shieh JY,Liao MH,Ling EA,Wen CY

    更新日期:1998-02-01 00:00:00

  • Adaptive ability to cope with atypical or novel situations involving tool use: an fMRI approach.

    abstract::We investigated the neural mechanisms underlying the ability to cope in atypical or novel situations using tools. We hypothesized that two cognitive components support this ability: adaptive coordination (for adapting to situational demands) and cognitive inhibition (for inhibiting the incongruent actions afforded by ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2014.03.008

    authors: Wakusawa K,Sugiura M,Sassa Y,Jeong H,Yomogida Y,Horie K,Sato S,Yokoyama H,Kure S,Takei N,Mori N,Kawashima R

    更新日期:2015-01-01 00:00:00

  • Reticulo-collicular and spino-collicular projections involved in eye and eyelid movements during the blink reflex.

    abstract::Reflex blinking provides a useful experimental tool for various functional studies on the peripheral and central nervous system, yet the neuronal circuitry underlying this reflex is not precisely known. In the present study, we investigated as to whether neurons in the reticular formation and rostral cervical spinal c...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2006.08.005

    authors: Smit AE,Buisseret P,Buisseret-Delmas C,De Zeeuw CI,VanderWerf F,Zerari-Mailly F

    更新日期:2006-12-01 00:00:00

  • Augmentation of GABA-induced chloride current in frog sensory neurons by diazepam.

    abstract::The effect of diazepam (DZP) on the GABA-induced macroscopic and microscopic Cl- current was investigated in isolated frog sensory neurons using both 'concentration-clamp' and patch-clamp techniques. At concentration range between 10(-9) and 10(-4) M, DZP itself evoked no response but potentiated time- and dose-depend...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(89)90023-0

    authors: Yakushiji T,Tokutomi N,Akaike N

    更新日期:1989-04-01 00:00:00

  • Evoked local cerebral blood flow induced by somatosensory stimulation is proportional to the baseline flow.

    abstract::The purpose of this study was to determine the relationship between the increase in local cerebral blood flow during neuronal activation (evoked LCBF) and the baseline flow level. We measured the hemodynamics in alpha-chloralose-anesthetized rats using laser-Doppler flowmetry during somatosensory stimulation under the...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(00)00175-9

    authors: Matsuura T,Fujita H,Kashikura K,Kanno I

    更新日期:2000-12-01 00:00:00

  • Comparison of the expression of two immediate early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brainstem during pregnancy, parturition and lactation.

    abstract::Medial preoptic area (MPA), supraoptic nucleus (SON), magnocellular (MaPVN) and parvocellular (PaPVN) paraventricular hypothalamic nuclei, and mesencephalic lateral tegmentum (MLT) are involved in maternal behavior, parturition and lactation. This study investigated the FosB and Fos immunoreactivity in these regions o...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(98)00100-x

    authors: Lin SH,Miyata S,Weng W,Matsunaga W,Ichikawa J,Furuya K,Nakashima T,Kiyohara T

    更新日期:1998-12-01 00:00:00

  • Zolpidem modulates GABA(A) receptor function in subthalamic nucleus.

    abstract::The subthalamic nucleus occupies a position in the indirect pathway of basal ganglia circuit, which plays an important role in the movement regulation. Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA(A) receptors containing alpha 1 subunit. Recently, zolpidem has been rep...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2007.02.002

    authors: Chen L,Xie JX,Fung KS,Yung WH

    更新日期:2007-05-01 00:00:00

  • Voltage-gated ionic currents and their roles in timing coding in auditory neurons of the nucleus magnocellularis of the chick.

    abstract::Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In volta...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(96)01071-1

    authors: Koyano K,Funabiki K,Ohmori H

    更新日期:1996-09-01 00:00:00

  • Pericyte function in the physiological central nervous system.

    abstract::Damage to the central nervous system (CNS) leads to disruption of the vascular network, causing vascular dysfunction. Vascular dysfunction is the major event in the pathogenesis of CNS diseases and is closely associated with the severity of neuronal dysfunction. The suppression of vascular dysfunction has been conside...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2014.01.007

    authors: Muramatsu R,Yamashita T

    更新日期:2014-04-01 00:00:00

  • Functional properties of strychnine-sensitive glycine receptors expressed in Xenopus oocytes injected with a single mRNA.

    abstract::Mature rat spinal cord cDNA libraries constructed in lambda gt10 and lambda ZAPII were screened with an oligonucleotide probe (39 mer), and 4 clones that possess DNA-inserts encoding a glycine receptor subunit were obtained. The cloned cDNAs were used to reconstruct the nucleotide sequence of the full-length open read...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(91)90064-6

    authors: Akagi H,Hirai K,Hishinuma F

    更新日期:1991-06-01 00:00:00

  • Hydrogen sulfide regulates intracellular pH in rat primary cultured glia cells.

    abstract::Intracellular pH (pH(i)) plays an important role in the regulation of central nervous system function. In the present study, we examined whether hydrogen sulfide (H(2)S), a recently recognized neuromodulator, regulates pH(i) in rat primary cultured glia cells. pH(i) was measured with a fluorescent sensitive dye, BCECF...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.09.1713

    authors: Lu M,Choo CH,Hu LF,Tan BH,Hu G,Bian JS

    更新日期:2010-01-01 00:00:00

  • Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors.

    abstract::Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarif...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2006.10.020

    authors: Dai H,Kaneko K,Kato H,Fujii S,Jing Y,Xu A,Sakurai E,Kato M,Okamura N,Kuramasu A,Yanai K

    更新日期:2007-02-01 00:00:00

  • Calcium-binding protein, secretagogin, characterizes novel groups of interneurons in the rat striatum.

    abstract::In the rat striatum numerous secretagogin (SCGN) positive neurons were scattered. They were heterogeneous in their morphological and chemical properties. We examined the colocalization of SCGN with known four interneuron markers, parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and choline acetyl transfe...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2017.01.004

    authors: Kosaka T,Yasuda S,Kosaka K

    更新日期:2017-06-01 00:00:00

  • Organizing motor imageries.

    abstract::Over the last few decades, motor imagery has attracted the attention of researchers as a prototypical example of 'embodied cognition' and also as a basis for neuro-rehabilitation and brain-machine interfaces. The current definition of motor imagery is widely accepted, but it is important to note that various abilities...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2015.11.003

    authors: Hanakawa T

    更新日期:2016-03-01 00:00:00