Haloperidol reduces the sympathetic and thermogenic activation induced by orexin A.

Abstract:

:This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before and 5 h after an injection of orexin A (1.5 nmol) into the lateral cerebral ventricle. The same variables were monitored in rats with an intraperitoneal administration of haloperidol (1 mg/kg bw), a D(2) receptor antagonist. The results show that orexin A increases the sympathetic firing rate, IBAT and colonic temperatures and heart rate. This increase is reduced by the haloperidol. These findings suggest that dopaminergic system is activated during the orexin A-induced hyperthermia.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Monda M,Viggiano A,De Luca V

doi

10.1016/s0168-0102(02)00191-8

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

17-23

issue

1

eissn

0168-0102

issn

1872-8111

pii

S0168010202001918

journal_volume

45

pub_type

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