Abstract:
:This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before and 5 h after an injection of orexin A (1.5 nmol) into the lateral cerebral ventricle. The same variables were monitored in rats with an intraperitoneal administration of haloperidol (1 mg/kg bw), a D(2) receptor antagonist. The results show that orexin A increases the sympathetic firing rate, IBAT and colonic temperatures and heart rate. This increase is reduced by the haloperidol. These findings suggest that dopaminergic system is activated during the orexin A-induced hyperthermia.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Monda M,Viggiano A,De Luca Vdoi
10.1016/s0168-0102(02)00191-8subject
Has Abstractpub_date
2003-01-01 00:00:00pages
17-23issue
1eissn
0168-0102issn
1872-8111pii
S0168010202001918journal_volume
45pub_type
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