Abstract：
:Many forms of psychopathology and/or psychiatric illness can occur through the pathways of altered environmental sensitivity, impulsivity, social functioning, and anxious responding. While these traits are also heritable, environmental conditions are known to play a critical role. The genetic factors that contribute to these traits may be adaptive in certain contexts, but can - under the environmental conditions commonly faced among modern humans - also be key moderators of risk for psychopathological outcomes. This article will discuss how animal studies inform us of the various environmental mechanisms through which prenatal or early postnatal environmental challenge can produce long-term effects on behavior and will briefly address how pre-copulatory, pre-natal and early postnatal epigenetic effects can contribute to persistent alterations in offspring behavior. Its main focus will be how nonhuman primate studies have helped us to understand how genetic vulnerability factors can moderate responses to early environmental factors, suggesting pathways through which early stress might produce long-term effects, thus pointing to systems that might moderate risk for psychiatric illnesses in humans.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Driscoll CA,Barr CSdoi
10.1016/j.neures.2015.08.001subject
Has Abstractpub_date
2016-01-01 00:00:00pages
67-77eissn
0168-0102issn
1872-8111pii
S0168-0102(15)00208-4journal_volume
102pub_type
杂志文章,评审abstract：:The subthalamic nucleus occupies a position in the indirect pathway of basal ganglia circuit, which plays an important role in the movement regulation. Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA(A) receptors containing alpha 1 subunit. Recently, zolpidem has been rep...
journal_title：Neuroscience research
pub_type： 杂志文章
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abstract：:Changes in the expression of estrogen-related substances in monkeys' brains at the menopausal transition, when estrogen deficit starts to occur, have not yet been examined thoroughly. In the present study, we immunohistochemically investigated the expression levels of estrogen receptor beta (ERβ) and aromatase (local ...
journal_title：Neuroscience research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.11.004
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pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00159-0
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01071-1
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.12.005
更新日期：2011-03-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.10.004
更新日期：2008-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.09.010
更新日期：2005-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00012-9
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.03.009
更新日期：2008-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2011-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00042-x
更新日期：1998-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.08.006
更新日期：2008-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.04.003
更新日期：2007-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.03.001
更新日期：2016-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.08.005
更新日期：2006-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1986-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2001-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.01.001
更新日期：2006-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00290-5
更新日期：2001-12-01 00:00:00
abstract：:Repetitive transcranial magnetic stimulation (rTMS), which could improve learning and memory, is widely used in psychiatry and neurology as a therapeutic approach. There are few studies reporting effective countermeasures to cognition decline in astronauts during space flight. Accordingly, we examined whether rTMS was...
journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.12.008
更新日期：2018-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)01162-0
更新日期：1997-04-01 00:00:00
abstract：:Glutamate receptor subtypes mediating excitatory synaptic neurotransmission in the cerebellar cortex are briefly reviewed from molecular biological, electrophysiological and pharmacological points of view. In particular, molecular biological findings of a novel family of AMPA-selective glutamate receptors are introduc...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(91)90023-r
更新日期：1991-01-01 00:00:00
