Antisense hippocampal knockdown of NMDA-NR1 by HVJ-liposome vector induces deficit of prepulse inhibition but not of spatial memory.

abstract：:We excised the dorsal part of the optic vesicle of chick embryos at stages 13-14 (embryonic day 2). The remainder of the optic vesicle reoganized and developed a small eye. This study was undertaken to determine how locus specificity is kept within the reorganized retina. The projection pattern from the reorganized ey...

journal_title：Neuroscience research

authors： Matsuno T,Itasaki N,Ichijo H,Nakamura H

更新日期：1992-10-01 00:00:00

abstract：:l-Serine is required for the synthesis of glycine and d-serine, both of which are NMDA receptor co-agonists. Although roles for d-serine and glycine have been suggested in schizophrenia, little is known about the role of the l-serine synthesizing cascade in schizophrenia or related psychiatric conditions. Here we repo...

journal_title：Neuroscience research

authors： Ozeki Y,Pickard BS,Kano S,Malloy MP,Zeledon M,Sun DQ,Fujii K,Wakui K,Shirayama Y,Fukushima Y,Kunugi H,Hashimoto K,Muir WJ,Blackwood DH,Sawa A

更新日期：2011-02-01 00:00:00

abstract：:Recent technologies and developments in neuroscience have contributed to remarkable scientific discoveries, and have also raised many new philosophical, ethical, legal, and social issues. Research in "neuroethics" has identified various ethical issues, which will be difficult for current biomedical ethics to resolve f...

journal_title：Neuroscience research

authors： Fukushi T,Sakura O,Koizumi H

更新日期：2007-01-01 00:00:00

abstract：:Amyloid-beta (Aβ) peptides, Aβ 1-42 (Aβ42) and Aβ43 in particular, cause neurotoxicity and cell death in the brain of Alzheimer's disease (AD) at higher concentrations. Carnosic acid (CA), a phenolic diterpene compound in the labiate herbs rosemary and sage, serves as an activator for neuroprotective and neurotrophic ...

journal_title：Neuroscience research

authors： Meng P,Yoshida H,Tanji K,Matsumiya T,Xing F,Hayakari R,Wang L,Tsuruga K,Tanaka H,Mimura J,Kosaka K,Itoh K,Takahashi I,Kawaguchi S,Imaizumi T

更新日期：2015-05-01 00:00:00

abstract：:Although sleep is strongly implicated in memory consolidation, the molecular basis for the role of sleep in memory is not known. It has been established that the consolidation of hippocampus-dependent memory depends on the activation of the Erk1,2 MAP kinase (MAPK) pathway which activates de novo CRE-mediated transcri...

journal_title：Neuroscience research

authors： Xia Z,Storm D

更新日期：2017-05-01 00:00:00

abstract：:In rat hippocampal CA1 neurons recorded intracellularly from tissue slices, a rapid depolarization occurred approximately 5 min after application of ischemia-simulating medium. In extracellular recordings obtained from CA1 region, a rapid negative-going DC potential (rapid DC potential) was recorded, corresponding to ...

journal_title：Neuroscience research

authors： Uchikado H,Tanaka E,Yamamoto S,Isagai T,Shigemori M,Higashi H

更新日期：2000-02-01 00:00:00

abstract：:NMDA receptors play an important functional role in the neuron excitability and plasticity. The conditions and consequences of their activation are of interest for many neuroscientists. This investigation was designed to explore an activation of the NMDA receptors of frog tectal neurons in vivo by a burst of spikes of...

journal_title：Neuroscience research

authors： Kuras A,Baginskas A,Batuleviciene V

更新日期：2006-04-01 00:00:00

abstract：:In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...

journal_title：Neuroscience research

authors： Liberini P,Valerio A,Moretto G,Rizzonelli P,Memo M,Rizzuto N,Spano PF

更新日期：1995-05-01 00:00:00

abstract：:Recent technological progress has yielded great amounts of information about the molecular constituents of postsynaptic scaffolds in the dendritic spine. Actin filaments are major cytoskeletal elements in the dendritic spine, and they functionally interact with neurotransmitter receptors via regulatory actin-binding p...

journal_title：Neuroscience research

authors： Shirao T,Sekino Y

更新日期：2001-05-01 00:00:00

abstract：:The radioprotective effect of herb epimedium (or yin yang huo) extract (5 g/kg, oral administration daily for 4 weeks) on neurogenesis and cognition after acute radiation exposure with 5.5 Gy was evaluated in Balb/c mice by behavioral tests and immunohistochemical study. The results indicated that epimedium extract co...

journal_title：Neuroscience research

authors： Wang SW,Ren BX,Qian F,Luo XZ,Tang X,Peng XC,Huang JR,Tang FR

更新日期：2019-08-01 00:00:00

abstract：:[3H]Glutamic acid binding to hippocampi was increased after amygdaloid kindling in rats, and diazepam inhibited this increased binding, without any effect on the enhanced binding by CaCl2 or the binding in control rats. By inducing kindling in the same way as that used in the binding experiment, the inhibiting effects...

journal_title：Neuroscience research

authors： Oka J,Yamada M,Goto M,Fukuda H

更新日期：1987-02-01 00:00:00

abstract：:Trans-2,4-dimethoxystibene (S(3)) is a synthetic stilbene. In this study, S(3) was investigated in terms of its neuroprotective effect against the toxicity induced by beta-amyloid(25-35) (Abeta(25-35)) both in vitro and in vivo. Protection by S(3) was studied at the in vivo level using a model of intracerebroventricul...

journal_title：Neuroscience research

authors： Ruan CJ,Zhang L,Chen DH,Li Z,Du GH,Sun L

更新日期：2010-07-01 00:00:00

abstract：:Dopaminergic neurons of the substantia nigra pars compacta play a major role in goal-directed behavior and reinforcement learning. The study of their local interactions has revealed that they are connected by electrical synapses. Connexins, the molecular substrate of electrical synapses, constitute a multigenic family...

journal_title：Neuroscience research

authors： Vandecasteele M,Glowinski J,Venance L

更新日期：2006-12-01 00:00:00

abstract：:Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane...

journal_title：Neuroscience research

authors： Furukawa K,Onodera H,Kogure K,Akaike N

更新日期：1993-02-01 00:00:00

abstract：:We recorded 101 neurons in the nucleus of the optic tract (NOT) of 3 rhesus monkeys. The neurons were tested in a variety of oculomotor paradigms. This report focusses on the modulation of NOT neuronal activity during smooth pursuit eye movements. A small horizontally moving spot (less than 1 degrees) elicited a direc...

journal_title：Neuroscience research

authors： Ilg UJ,Hoffmann KP

更新日期：1991-10-01 00:00:00

abstract：:The 14-3-3 protein family consists of evolutionarily conserved, acidic 30 kDa proteins composed of seven isoforms named beta, gamma, epsilon, zeta, eta, theta, and sigma in mammalian cells. The dimeric complex of 14-3-3 isoforms, acting as a molecular adaptor, plays a central role in regulation of neuronal function. S...

journal_title：Neuroscience research

authors： Tabunoki H,Shimada T,Banno Y,Sato R,Kajiwara H,Mita K,Satoh J

更新日期：2008-07-01 00:00:00

abstract：:Huntington's disease (HD) is caused due to expansion of CAG repeats in the gene huntingtin (Htt). Adaptor protein Grb2, involved in Ras-MAP kinase pathway, is a known interactor of Htt. Mutant Htt-Grb2 interaction reduces Ras-MAPK signaling in HD models. In normal cells Grb2 forms Grb2-Sos1-Gab1 complex through its N-...

journal_title：Neuroscience research

authors： Baksi S,Basu S,Mukhopadhyay D

更新日期：2014-10-01 00:00:00

abstract：:The synthesis of glial-fibrillary acidic protein (GFAP) or the re-expression of progenitor markers such as Nestin increases in reactive astrocytes after brain ischemia. We investigated the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-bindin...

journal_title：Neuroscience research

authors： Oki K,Kaneko N,Kanki H,Imai T,Suzuki N,Sawamoto K,Okano H

更新日期：2010-04-01 00:00:00

abstract：:A single-pulse TMS to the human motor cortex (M1) influences reaction time (RT). We may summarize from previous studies where different groups of subjects participated in various types of RT tasks that TMS above motor threshold (MT) delays RT, whereas TMS below MT shortens RT and that these RT changes depends on TMS t...

journal_title：Neuroscience research

authors： Hashimoto T,Inaba D,Matsumura M,Naito E

更新日期：2004-12-01 00:00:00

abstract：:The effect of diazepam (DZP) on the GABA-induced macroscopic and microscopic Cl- current was investigated in isolated frog sensory neurons using both 'concentration-clamp' and patch-clamp techniques. At concentration range between 10(-9) and 10(-4) M, DZP itself evoked no response but potentiated time- and dose-depend...

journal_title：Neuroscience research

authors： Yakushiji T,Tokutomi N,Akaike N

更新日期：1989-04-01 00:00:00

abstract：:Whole-cell recordings were performed to examine the morphological properties of electrophysiologically classified area postrema (AP) neurons in rat brain slices. Using electrophysiological criteria, AP neurons were subdivided into three groups: (1) cells displaying both the hyperpolarization-activated cation current (...

journal_title：Neuroscience research

authors： Funahashi M,Mitoh Y,Akaike T,Matsuo R

更新日期：2006-01-01 00:00:00

abstract：:The effect of apamin, a bee venom toxin, on the action potential and the spike after hyperpolarization was studied in bullfrog sympathetic ganglion cells. Apamin reduced the duration of the afterhyperpolarization but did not affect the maximum rates of rise and fall of Na+- and Ca2+-dependent action potentials. In the...

journal_title：Neuroscience research

authors： Koyano K,Abe T

更新日期：1985-12-01 00:00:00

abstract：:To elucidate the interaction between nitric oxide (NO) and substance P (SP) in neurogenic inflammatory responses, we measured the change in the degree of Evans blue leakage and NO levels in perfusate from the subcutaneous space in the rat instep following noxious heat stimulation (47 degrees C for 30 min). Furthermore...

journal_title：Neuroscience research

authors： Yonehara N,Yoshimura M

更新日期：2000-01-01 00:00:00

abstract：:Using median nerve injury and immunocytochemical methods, we examined the temporal changes in neuropeptide Y (NPY) expression in the cuneate nucleus (CN) in rats following median nerve transection. Under normal circumstances, neuropeptide Y-immunoreactive (NPY-IR) fibers was not detectable in the CN. A few NPY-IR fibe...

journal_title：Neuroscience research

authors： Tsai YJ,Leong SM,Day AS,Wen CY,Shieh JY,Lue JH

更新日期：2004-04-01 00:00:00

abstract：:Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...

journal_title：Neuroscience research

authors： Okada M,Sakaguchi T,Kawasaki K

更新日期：1995-07-01 00:00:00

abstract：:In anesthetized and immobilized Japanese monkeys (Macaca fuscata), intraretinal conduction velocities of the ganglion cell axons were measured. The field potentials elicited by optic chiasm shocks consisted of fast and slow components with estimated conduction velocities of 1.19 and 0.72 m/s in recordings from the opt...

journal_title：Neuroscience research

authors： Fukuda Y,Watanabe M,Wakakuwa K,Sawai H,Morigiwa K

更新日期：1988-10-01 00:00:00

abstract：:The effects of substance P (SP) on cholinergic transmission were studied at the neuromuscular junction of frogs by intracellular and voltage-clamp recording methods. Bath application of SP increased the amplitude of end-plate potential (e.p.p.) evoked in either low-Ca2+ -high Mg2+ or curare-containing solution. SP at ...

journal_title：Neuroscience research

authors： Akasu T

更新日期：1986-05-01 00:00:00

abstract：:We have generated a transgenic mouse model in which astrocytes express an enhanced green fluorescent protein (EGFP) under the control of the mouse glial fibrillary acidic protein (GFAP) promoter. EGFP, which is characteristically found throughout the cell, was expressed in these animals even in astrocytic fine process...

journal_title：Neuroscience research

authors： Suzuki R,Watanabe J,Arata S,Funahashi H,Kikuyama S,Shioda S

更新日期：2003-12-01 00:00:00

abstract：:Neuropsin is a serine protease cloned from the mouse hippocampus. Since neuropsin is a secreted protein which effectively cleaves fibronectin, it may affect cell adhesion or cell migration by modulating the content and/or chemical characteriscs of fibronectin in extracellular matrix (ECM). In adhesion assays, alpha5B2...

journal_title：Neuroscience research

authors： Tani N,Matsumoto K,Ota I,Yoshida S,Takada Y,Shiosaka S,Matsuura N

更新日期：2001-02-01 00:00:00

abstract：:Swelling of brain cells is one of the physiological responses associated with neuronal activation. To investigate underlying mechanisms, we analyzed interactions between changes in cell volume and synaptic responses in the hippocampal slices from rodents. Swelling within the CA1 area was detected as increases in trans...

journal_title：Neuroscience research

authors： Takagi S,Obata K,Tsubokawa H

更新日期：2002-11-01 00:00:00