Role of circadian rhythm and REM sleep for memory consolidation.

abstract：:Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...

journal_title：Neuroscience research

authors： Sudo K,Ito H,Iwamoto I,Morishita R,Asano T,Nagata K

更新日期：2006-12-01 00:00:00

abstract：:Ethanol's actions in brain have been suggested to be partially mediated by a mechanism involving the ethanol-induced activation of the endogenous opioid system. Opioid systems, which are closely linked with dopamine transmission, are thought to be affected by ethanol through alterations in the processing, release, and...

journal_title：Neuroscience research

authors： Méndez M,Leriche M,Carlos Calva J

更新日期：2003-10-01 00:00:00

abstract：:Nandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal gro...

journal_title：Neuroscience research

authors： Salimi Z,Khajehpour L,Moradpour F,Moazedi AA,Pourmotabbed A,Zarei F

更新日期：2020-09-01 00:00:00

abstract：:To investigate the representation of facial skin areas in the primary somatosensory cortex (SI), we recorded magnetic fields evoked by air pressure-induced tactile stimulation applied to six points on the face, lower lip and thumb. The thumb area in the SI was located more medial and superior to the lip area, which wa...

journal_title：Neuroscience research

authors： Nguyen BT,Tran TD,Hoshiyama M,Inui K,Kakigi R

更新日期：2004-10-01 00:00:00

abstract：:The entopeduncular nucleus (EPN) is one of the major output nuclei of the basal ganglia in rodents. Previous studies have divided it into rostral and caudal halves, with the former containing somatostatin (SOM)-immunoreactive neurons and the latter dominated by parvalbumin (PV)-containing neurons, respectively. Howeve...

journal_title：Neuroscience research

authors： Miyamoto Y,Fukuda T

更新日期：2015-05-01 00:00:00

abstract：:DJ-1 is a multifunctional protein linked to recessively inherited Parkinson's disease (PD) due to loss of function mutations. Among its activities is anti-oxidant property leading to cytoprotection under oxidative stress conditions. A key effector of oxidant-induced cell death is the MAP3 kinase apoptosis signal-regul...

journal_title：Neuroscience research

authors： Im JY,Lee KW,Junn E,Mouradian MM

更新日期：2010-07-01 00:00:00

abstract：:Recent technological progress has yielded great amounts of information about the molecular constituents of postsynaptic scaffolds in the dendritic spine. Actin filaments are major cytoskeletal elements in the dendritic spine, and they functionally interact with neurotransmitter receptors via regulatory actin-binding p...

journal_title：Neuroscience research

authors： Shirao T,Sekino Y

更新日期：2001-05-01 00:00:00

abstract：:Immunohistochemical staining for GD3 in adult rat brain was carried out using mouse IgM anti-GD3 monoclonal antibody (DSG-1). Neuronal cells in the cerebral cortex, striatum, hippocampus and various nuclei of the thalamus were immunoreactive. In the cerebellum, Purkinje cells, granule cells and also basket cells were ...

journal_title：Neuroscience research

authors： Kawai K,Mori M,Watarai S,Yasuda T

更新日期：1994-03-01 00:00:00

abstract：:Narcolepsy is a chronic sleep disorder marked by excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic hallucinations. Since the discovery of sleep onset REM periods (SOREMPs) in narcoleptic patients, narcolepsy has often been regarded as a disorder of REM sleep generation: REM sleep intrudes in act...

journal_title：Neuroscience research

authors： Nishino S,Riehl J,Hong J,Kwan M,Reid M,Mignot E

更新日期：2000-12-01 00:00:00

abstract：:Lateral (L) and medial (M) midbrain astrocytes differ in their ability to support neuritic growth (L, permissive; M, non-permissive) with properties of M glia depending on heparan sulfate (HS). Here we show by atomic force microscopy that the surfaces of formaldehyde-fixed astrocytes differ by conspicuous 250 nm protr...

journal_title：Neuroscience research

authors： Weissmüller G,Garcia-Abreu J,Mascarello Bisch P,Moura Neto V,Cavalcante LA

更新日期：2000-10-01 00:00:00

abstract：:During development, neurons migrate from their origin to their final destinations where they form neuronal architectures such as layers and nuclei. While the mechanisms for the formation of laminated structures have been studied extensively, little is known about nucleogenesis. Previously, we analyzed nucleogenesis in...

journal_title：Neuroscience research

authors： Watanabe H,Murakami F

更新日期：2009-05-01 00:00:00

abstract：:We have previously shown that endothelin-B receptor stimulation increases neural progenitor proliferation, partly in G(i) and extracellular matrix molecule-dependent manner. In the present study, we investigated whether G(q/11) is also involved in this response and how G(i) and G(q/11) might regulate the extracellular...

journal_title：Neuroscience research

authors： Morishita R,Ueda H,Ito H,Takasaki J,Nagata K,Asano T

更新日期：2007-10-01 00:00:00

abstract：:Because a potential treatment for brain injuries could be elevating magnesium ions (Mg(2+)) intracerebrally, we characterized the effects of elevating external Mg(2+) in cultures of neonatal murine brain-derived neural stem/progenitor cells (NSCs). Using a crystal violet assay, which avoids interference of Mg(2+) in t...

journal_title：Neuroscience research

authors： Vennemeyer JJ,Hopkins T,Kuhlmann J,Heineman WR,Pixley SK

更新日期：2014-07-01 00:00:00

abstract：:Confocal laser scanning microscopy (CLSM) was used to record spatial and dynamic changes in the intracellular Ca2+ [(Ca2+]i) of bullfrog sympathetic ganglion cells in excised tissue or in culture. A CLSM utilizing Ar ion laser (488 nm) and recording fluo-3 fluorescence yielded the sliced image of ganglion cells, while...

journal_title：Neuroscience research

authors： Kuba K,Hua SY,Nohmi M

更新日期：1991-05-01 00:00:00

abstract：:Changes in levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) in various regions of the rat brain following kainic acid-induced seizure activity were investigated. BDNF protein, as measured by a two-site enzyme immunoassay, increased transiently 12-24 h after the in...

journal_title：Neuroscience research

authors： Katoh-Semba R,Takeuchi IK,Inaguma Y,Ito H,Kato K

更新日期：1999-10-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a recently identified member of the secretin/vasoactive intestinal polypeptide (VIP) family. There are at least two types of receptor for PACAP: type I (PACAPR), which specifically binds PACAP; and type II (VIP/PACAPR), which binds both PACAP and VIP. The l...

journal_title：Neuroscience research

authors： Shioda S,Shuto Y,Somogyvari-Vigh A,Legradi G,Onda H,Coy DH,Nakajo S,Arimura A

更新日期：1997-08-01 00:00:00

abstract：:We newly developed an infrared video-oculographic system for on-line tracking of the eye position in awake and head-fixed mice, with high temporal resolution (240 Hz). The system consists of a commercially available high-speed CCD camera and an image processing software written in LabVIEW run on IBM-PC with a plug-in ...

journal_title：Neuroscience research

authors： Sakatani T,Isa T

更新日期：2004-05-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant inheritable neurodegenerative disorder currently without effective treatment. It is caused by an expanded polyglutamine (poly Q) tract in the corresponding protein, huntingtin (htt), and therefore suppressing the huntingtin expression in brain neurons is expected to d...

journal_title：Neuroscience research

authors： Wang YL,Liu W,Wada E,Murata M,Wada K,Kanazawa I

更新日期：2005-11-01 00:00:00

abstract：:Executive Functions (EFs) involve a set of high cognitive abilities impairment which have been successfully related to a redox omeostasis imbalance in several psychiatric disorders. Firstly, we aimed to investigate the relationship between executive functioning and some oxidative metabolism parameters in Peripheral Bl...

journal_title：Neuroscience research

authors： Pesce M,Rizzuto A,La Fratta I,Tatangelo R,Campagna G,Iannasso M,Ferrone A,Franceschelli S,Speranza L,Patruno A,De Lutiis MA,Felaco M,Grilli A

更新日期：2016-05-01 00:00:00

abstract：:It is still incompletely known how NMDA receptors (NMDA-R) regulate bidirectional synaptic plasticity. We examined this issue by an experimental protocol in which paired pulse stimulation (PPS) with 50ms interstimulus interval and basal frequency of 0.1Hz was applied to CA1 area of rat hippocampal slices during low Mg...

journal_title：Neuroscience research

authors： Huang FS,Abbas AK,Li R,Afanasenkau D,Wigström H

更新日期：2010-06-01 00:00:00

abstract：:In the present study, the ability of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in the hippocampus to enhance locomotor activity in rats was investigated by local infusion. Intraperitoneal injection of the selective 5-HT(2C) antagonist SB 242084 (1 mg/kg) significantly increased rats motor activity, while the effect...

journal_title：Neuroscience research

authors： Takahashi H,Takada Y,Urano T,Takada A

更新日期：2001-05-01 00:00:00

abstract：:Recent advances in our understanding of brain function have come from using light to either control or image neuronal activity. Here we describe an approach that combines both techniques: a micromirror array is used to photostimulate populations of presynaptic neurons expressing channelrhodopsin-2, while a red-shifted...

journal_title：Neuroscience research

authors： Tsuda S,Kee MZ,Cunha C,Kim J,Yan P,Loew LM,Augustine GJ

更新日期：2013-01-01 00:00:00

abstract：:Sleep disturbances are common in psychiatric disorders, but the causal relationship between the two and the underlying genetic factors is unclear. The DISC1 gene is strongly linked to mood disorders and schizophrenia in a Scottish pedigree. In an earlier study we found a sleep homeostasis disturbance in a Drosophila m...

journal_title：Neuroscience research

authors： Jaaro-Peled H,Altimus C,LeGates T,Cash-Padgett T,Zoubovsky S,Hikida T,Ishizuka K,Hattar S,Mongrain V,Sawa A

更新日期：2016-11-01 00:00:00

abstract：:In rat models of Parkinson's disease, injections of 6-hydroxydopamine (6-OHDA) into different areas of the basal ganglia result in dopaminergic neurodegeneration in the substantia nigra. The extent and time course of the dopaminergic lesions varies between the models. While the effects on neurons have been extensively...

journal_title：Neuroscience research

authors： Henning J,Strauss U,Wree A,Gimsa J,Rolfs A,Benecke R,Gimsa U

更新日期：2008-12-01 00:00:00

abstract：:RNA editing provides a post-transcriptional mechanism to increase structural heterogeneity of gene products. Recently, the alpha3 subunit of the GABAA receptors has been shown to undergo RNA editing. As a result, a highly conserved isoleucine residue in the third transmembrane domain is replaced with a methionine. To ...

journal_title：Neuroscience research

authors： Nimmich ML,Heidelberg LS,Fisher JL

更新日期：2009-04-01 00:00:00

abstract：:Developmental refinement of neuronal connectivity is crucial for proper brain function. In the early phase of development, input fibers arrive at their target areas guided by specific molecular cues and form abundant immature synapses. Then, functionally important synapses are preserved and strengthened by neural acti...

journal_title：Neuroscience research

authors： Narushima M

更新日期：2018-04-01 00:00:00

abstract：:We carried out voltage-sensitive dye imaging of the guinea pig auditory cortex to determine whether the ongoing and spontaneous activities of the cortex exhibit spatial coherence reflecting the tonotopic organization of the cortex. We used independent component analysis and a signal-plus-noise model to extract ongoing...

journal_title：Neuroscience research

authors： Yoshida T,Sakagami M,Katura T,Yamazaki K,Tanaka S,Iwamoto M,Tanaka N

更新日期：2008-05-01 00:00:00

abstract：:POZ/BTB proteins influence cellular development and in some examples act as oncoproteins. However, several POZ/BTB transcription factors have been found in terminally differentiated neurons, where their functions remain unknown. One example is NAC1, a constitutively-expressed protein that can regulate behaviors associ...

journal_title：Neuroscience research

authors： Korutla L,Neustadter JH,Fournier KM,Mackler SA

更新日期：2003-05-01 00:00:00

abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...

journal_title：Neuroscience research

authors： Bernstein DL,Nayak SU,Oliver CF,Rawls SM,Rom S

更新日期：2020-06-01 00:00:00

abstract：:How the nervous system controls the sensation and memory of information from the environment is an essential question. The nematode Caenorhabditis elegans is a useful model for elucidating neural information processing that mediates sensation and memory. The entire nervous system of C. elegans consists of only 302 neu...

journal_title：Neuroscience research

authors： Ohta A,Kuhara A

更新日期：2013-07-01 00:00:00