Abstract：
:We newly developed an infrared video-oculographic system for on-line tracking of the eye position in awake and head-fixed mice, with high temporal resolution (240 Hz). The system consists of a commercially available high-speed CCD camera and an image processing software written in LabVIEW run on IBM-PC with a plug-in video grabber board. This software calculates the center and area of the pupil by fitting circular function to the pupil boundary, and allows robust and stable tracking of the eye position in small animals like mice. On-line calculation is performed to obtain reasonable circular fitting of the pupil boundary even if a part of the pupil is covered with shadows or occluded by eyelids or corneal reflections. The pupil position in the 2-D video plane is converted to the rotation angle of the eyeball by estimating its rotation center based on the anatomical eyeball model. By this recording system, it is possible to perform quantitative analysis of rapid eye movements such as saccades in mice. This will provide a powerful tool for analyzing molecular basis of oculomotor and cognitive functions by using various lines of mutant mice.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Sakatani T,Isa Tdoi
10.1016/j.neures.2004.02.002subject
Has Abstractpub_date
2004-05-01 00:00:00pages
123-31issue
1eissn
0168-0102issn
1872-8111pii
S0168010204000276journal_volume
49pub_type
杂志文章abstract：:We studied the patterns of membrane potential changes in vocal cord tensor motoneurons, i.e. cricothyroid muscle motoneurons (CTMs), during fictive breathing, vocalization, coughing, and swallowing in decerebrate paralyzed cats to determine the nature of central drives to CTMs during these behaviors. CTMs were identif...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.03.009
更新日期：2004-07-01 00:00:00
abstract：:To elucidate the molecular mechanisms that regulate the maturation of action potential, we began by examining voltage-dependent K+ currents, known to contribute to the maturation of action potential, of developing granule cells in mouse cerebellar microexplant cultures. The migration of developing granule cells in thi...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00099-0
更新日期：1997-12-01 00:00:00
abstract：:Bacterial lipopolysaccharide (LPS) is a major component of the cell wall of gram negative bacteria contributing to the pathogenesis of bacterial infection, in particular in those diseases affecting central nervous system and reproductive tissues. The present work is an attempt to study the regulation of steroidogenic ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.02.011
更新日期：2014-06-01 00:00:00
abstract：:Our purpose was to elucidate the functional roles of the laryngeal afferents in controlling vocalization. We investigated the effects of laryngeal deafferentation (sectioning the internal branch of the superior laryngeal nerve (ISLN)) on respiration and voice quality during electrically-induced vocalization in twelve ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00877-v
更新日期：1995-03-01 00:00:00
abstract：:Effective connectivity analysis has been widely applied to noninvasive recordings such as functional magnetic resonance imaging and electroencephalograms (EEGs). Previous studies have aimed to extract the causal relations between brain regions, but the validity of the derived connectivity has not yet been fully determ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.09.003
更新日期：2020-07-01 00:00:00
abstract：:We examined the effects of the gravitational vertical on the perception of reversible figures. Each reversible figure had two interpretations depending on whether it was viewed vertically in one orientation or upside down. When it was presented horizontally, the two interpretations alternated. Subjects were required t...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.02.014
更新日期：2006-06-01 00:00:00
abstract：:Nandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal gro...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.09.001
更新日期：2020-09-01 00:00:00
abstract：:Recently, we have found novel mammalian tachykinins, neurokinin alpha and beta isolated from porcine spinal cord, whose chemical structures are similar to those of substance P or kassinin. In the present study, we describe a specific assay system for neurokinin alpha and beta by combining HPLC and radioimmunoassay. We...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(84)90009-9
更新日期：1984-12-01 00:00:00
abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.07.003
更新日期：2020-06-01 00:00:00
abstract：:Responses of Purkinje cells to parallel fibre stimulation and to ionophoretically applied glutamate agonists, L-glutamate, L-aspartate, quisqualate, kainate and N-methyl-D-aspartate (NMDA), were extracellularly recorded in a superficial folium of the dorsal paraflocculus of high-decerebrate rabbits. NMDA caused an inh...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(88)90034-x
更新日期：1988-04-01 00:00:00
abstract：:Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie con...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2019.10.002
更新日期：2020-07-01 00:00:00
abstract：:Type B neurons of the bullfrog sympathetic ganglia were examined to confirm the existence of axon collaterals and the distribution of synaptic contacts using the intracellular horseradish peroxidase (HRP) labeling method. The mean diameter of the perikarya was 60.8 (+/- 11.5 standard deviation; n = 36) X 43.8 (+/- 11....
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90035-7
更新日期：1989-10-01 00:00:00
abstract：:Executive Functions (EFs) involve a set of high cognitive abilities impairment which have been successfully related to a redox omeostasis imbalance in several psychiatric disorders. Firstly, we aimed to investigate the relationship between executive functioning and some oxidative metabolism parameters in Peripheral Bl...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.11.007
更新日期：2016-05-01 00:00:00
abstract：:Projection fields in the striatum and claustrum from eye movement-evoking cerebral cortices (EMECs) in the cat were investigated using the WGA-HRP tracing method under electrophysiological guidance to place WGA-HRP in the appropriate sites. The EMECs in the frontal cortex, which are located in the medial wall under th...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90033-b
更新日期：1990-08-01 00:00:00
abstract：:Whole-cell recordings were performed to examine the morphological properties of electrophysiologically classified area postrema (AP) neurons in rat brain slices. Using electrophysiological criteria, AP neurons were subdivided into three groups: (1) cells displaying both the hyperpolarization-activated cation current (...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.10.005
更新日期：2006-01-01 00:00:00
abstract：UNLABELLED:Angiotensin II receptors (Ang II), classified into AT1 and AT2 subtypes, are located in different regions of the central nervous system, including the cardiovascular control centers in the medulla oblongata. We previously reported the role of Ang II AT1 receptors within the medulla on cardiovascular response...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.04.008
更新日期：2009-08-01 00:00:00
abstract：:This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley r...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00191-8
更新日期：2003-01-01 00:00:00
abstract：:In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00897-2
更新日期：1995-05-01 00:00:00
abstract：:Nerve growth factor (NGF)-like immunoreactivity was demonstrated in the rat pituitary intermediate lobe by indirect immunofluorescence method using antisera specific to beta-NGF isolated from adult male mouse submaxillary salivary gland. Co-culture of frozen or fresh intermediate lobes with newborn rat superior cervic...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(88)90014-4
更新日期：1988-12-01 00:00:00
abstract：:To investigate how motor programs can be modified by sensory inputs we recorded kinematic and EMG patterns from normal human subjects performing well-practised wrist flexion movements in response to an auditory tone. On random trials unexpected wrist perturbations were introduced at varying times after the signal to m...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90062-j
更新日期：1990-06-01 00:00:00
abstract：:The distribution of neurofilament proteins and peripherin in the pituitary gland of the rat was studied with a panel of monoclonal and polyclonal antibodies recognizing different neurofilament subunits. In the posterior lobe, a dense plexus of neurofilament- and peripherin-immunoreactive fibers was seen. In the interm...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00903-7
更新日期：1995-06-01 00:00:00
abstract：:To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.01.005
更新日期：2005-05-01 00:00:00
abstract：:Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00911-c
更新日期：1995-07-01 00:00:00
abstract：:Speech prosody is considered to be one of the most important sources of information for infants in acquiring their native language. Using multi-channel near-infrared spectroscopy in 10-month-old infants, we examined cortical activation when normal and flattened speech sounds were presented to the infants. The flattene...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.05.005
更新日期：2007-09-01 00:00:00
abstract：:Maternal stress, viral infection, and obstetric complications, which trigger cytokine signaling, are hypothesized to be involved in schizophrenia and its related disorders. The etiologic contribution of individual cytokines to such psychiatric disorders, however, remains to be evaluated. To estimate the impact of peri...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.05.010
更新日期：2004-09-01 00:00:00
abstract：:In this communication, I first summarize the mechanisms underlying human voluntary movements and define the involuntary movements (medical term). CLASSIFICATION OF HUMAN MOVEMENTS:Human movements are classified into two main kinds: intentional movements and non-intentional movements in which the involuntary movements...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2019.10.001
更新日期：2020-07-01 00:00:00
abstract：:Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00025-1
更新日期：2002-06-01 00:00:00
abstract：:A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.05.001
更新日期：2011-08-01 00:00:00
abstract：:In an attempt to test the possibility that sino-aortic baroreceptors may mediate the previously reported stress response in hypothalamic magnocellular neurosecretory cell activity in rats, effects of deafferentation of sino-aortic baroreceptors on plasma levels of vasopressin and oxytocin after fear-related emotional ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90059-l
更新日期：1992-04-01 00:00:00
abstract：:The organization of the sagittal Zone C of the cerebellar cortex of the rat was studied with respect to its efferent projections and to its inferior olive (IO) afferent connections. Wheat-germ agglutinin conjugated to horseradish peroxidase was used as a tracer. Zone C has been defined as the cortical region projectin...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(88)90039-9
更新日期：1988-08-01 00:00:00
