Abstract:
:Recently, we have found novel mammalian tachykinins, neurokinin alpha and beta isolated from porcine spinal cord, whose chemical structures are similar to those of substance P or kassinin. In the present study, we describe a specific assay system for neurokinin alpha and beta by combining HPLC and radioimmunoassay. We investigated the regional distribution of tachykinins including substance P in the rat central nervous system using anti-neurokinin alpha antiserum which cross-reacts 25% with neurokinin beta. As a result, it is noted that substance P was the highest in concentration in the rat substantia nigra, the striatum, the cerebellum and the spinal cord, but not in the cerebral cortex in which neurokinin beta was the highest. Concentration of neurokinin alpha was lower than that of substance P and the molar ratio of substance P and neurokinin alpha was fairly constant (2.8-4.0) in all regions. On the other hand, it is noted that the molar ratio of substance P and neurokinin beta was extremely variable and seemed to be specific to tissues.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Kanazawa I,Ogawa T,Kimura S,Munekata Edoi
10.1016/0168-0102(84)90009-9subject
Has Abstractpub_date
1984-12-01 00:00:00pages
111-20issue
1-2eissn
0168-0102issn
1872-8111pii
0168-0102(84)90009-9journal_volume
2pub_type
杂志文章abstract::While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synth...
journal_title:Neuroscience research
pub_type: 临床试验,杂志文章
doi:10.1016/s0168-0102(02)00007-x
更新日期:2002-04-01 00:00:00
abstract::The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression. In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.12.020
更新日期:2011-04-01 00:00:00
abstract::Opiates have been used extensively in the treatment of pain but with the severe side effect of addiction, which is believed to be related to opiates' direct (primary) or indirect (secondary) neurotoxicity. In this study, the effects of opioids on cell growth and apoptosis have been examined in human neuroblastoma cell...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00080-1
更新日期:1997-10-01 00:00:00
abstract::We examined effects of carbachol (CCh), muscarinic receptor agonist, on long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) at Schaffer collateral-CA1 synapse of guinea pig hippocampal slices using extracellular recording technique. Application of 0.1 microM CCh to the slices significantly ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(96)01147-9
更新日期:1997-02-01 00:00:00
abstract::The hippocampus communicates with the neocortex via the entorhinal cortex and is thought to be critically involved in the consolidation of memories. This paper contains in vivo evidence of a projection from the hippocampal area CA1 to the entorhinal cortex. Current theories of memory formation suggest that the backpro...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.06.009
更新日期:2005-10-01 00:00:00
abstract::A group of brain acid-soluble proteins (BASPs) is preliminarily characterized. In some respects BASPs are similar to high mobility group (HMG) proteins, but in contrast to HMG, all BASPs are very acidic (pI 4.4-4.6) and show abnormal mobility during SDS-PAGE electrophoresis. BASP2-1 and BASP2-2 are identified as the t...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(94)90146-5
更新日期:1994-03-01 00:00:00
abstract::The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.10.009
更新日期:2008-02-01 00:00:00
abstract::Adult neurogenesis is a process of generating new neurons from neural stem/precursor cells (NS/PCs) in restricted adult brain regions throughout life. It is now generally known that adult neurogenesis in the hippocampal dentate gyrus (DG) and subventricular zone participates in various higher brain functions, such as ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2018.05.007
更新日期:2019-06-01 00:00:00
abstract::Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2014.02.003
更新日期:2014-04-01 00:00:00
abstract::Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2017.02.004
更新日期:2017-07-01 00:00:00
abstract::The distribution of ryanodine receptor-like immunoreactivity in the mouse central nervous system was studied using two antibodies raised against synthetic peptides. These peptides represented a region conserved between the cardiac and skeletal muscle forms and a region specific to the cardiac form. Western blotting an...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(92)90026-9
更新日期:1992-10-01 00:00:00
abstract::The organization of the sagittal Zone C of the cerebellar cortex of the rat was studied with respect to its efferent projections and to its inferior olive (IO) afferent connections. Wheat-germ agglutinin conjugated to horseradish peroxidase was used as a tracer. Zone C has been defined as the cortical region projectin...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(88)90039-9
更新日期:1988-08-01 00:00:00
abstract::In lightly alpha-chloralose anaesthetized cats, activity was recorded simultaneously from 2-4 primary muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles. Increased tension in medial or lateral collateral ligament was found to evoke changes in the responses of the primary spi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90066-8
更新日期:1991-06-01 00:00:00
abstract::We investigated brain activity in 3-5-year-old preschoolers as they listened to connected speech stimuli in Japanese (first language), English (second language), and Chinese (a rarely exposed, foreign language) using near-infrared spectroscopy. Unlike the younger preschoolers who had been exposed to English for almost...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.02.004
更新日期:2012-05-01 00:00:00
abstract::In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00897-2
更新日期:1995-05-01 00:00:00
abstract::NAP-22, a neuronal tissue-enriched acidic membrane protein, is a Ca(2+)-dependent calmodulin binding protein and has similar biochemical characteristics to GAP-43 (neuromodulin). Recent biochemical studies have demonstrated that NAP-22 localizes in the membrane raft domain with a cholesterol-dependent manner. Since th...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(00)00132-2
更新日期:2000-08-01 00:00:00
abstract::To investigate the representation of facial skin areas in the primary somatosensory cortex (SI), we recorded magnetic fields evoked by air pressure-induced tactile stimulation applied to six points on the face, lower lip and thumb. The thumb area in the SI was located more medial and superior to the lip area, which wa...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.07.004
更新日期:2004-10-01 00:00:00
abstract::Neuronal development is composed of the complex steps which involve many signaling proteins. On the other hand, there are many proteins highly expressed in the differentiated neurons at developmental stages, but of which physiological functions are not precisely known so far. Glycoprotein 6a (GPM6a) currently belongs ...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2017.11.002
更新日期:2018-03-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) is a recently identified member of the secretin/vasoactive intestinal polypeptide (VIP) family. There are at least two types of receptor for PACAP: type I (PACAPR), which specifically binds PACAP; and type II (VIP/PACAPR), which binds both PACAP and VIP. The l...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00065-5
更新日期:1997-08-01 00:00:00
abstract::To evaluate recovery function of and effects of hyperventilation (HV) on high-frequency oscillations (HFOs) of median nerve somatosensory evoked potential (SEP), we recorded SEPs in 8 Parkinson's disease (PD) patients with enlarged HFOs, 4 myoclonus epilepsy (ME) patients and 10 healthy volunteers (N). SEP was recorde...
journal_title:Neuroscience research
pub_type: 临床试验,杂志文章
doi:10.1016/s0168-0102(03)00129-9
更新日期:2003-08-01 00:00:00
abstract::L-glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system and has also been implicated as a potent neurotoxin. To ensure a high signal-to-noise ratio during synaptic transmission and to prevent neuronal damage that might occur as a result of excessive activation of glutamate recept...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/s0168-0102(00)00104-8
更新日期:2000-05-01 00:00:00
abstract::Chemokines related neuroinflammation and N-methyl-d-aspartate receptor (NMDAR) mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid-induced hyperalgesia (OIH), but little is known about specific mechanism and treatment. Chemokine CXCL12 with its receptor CXCR4 is implicated in diffe...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2018.07.007
更新日期:2019-07-01 00:00:00
abstract::The cerebellar Purkinje cell has highly branched dendrites extending in a transverse plane to the cerebellar folium. Branching patterns of the dendrites were subjected to fractal analysis to obtain a quantitative measure of their intricacy. Using a square-covering method, we found that dendrites have a statistical sel...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(92)90031-7
更新日期:1992-02-01 00:00:00
abstract::The occurrence of multiple proteoglycan species is a characteristic of the brain. The structural features of individually characterized proteoglycans in the brain are first introduced in brief, then some examples are shown that suggest a relationship between multiple proteoglycans and the many distinct cell types and ...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/0168-0102(94)90088-4
更新日期:1994-09-01 00:00:00
abstract::Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00036-6
更新日期:2002-07-01 00:00:00
abstract::Dopamine is a major neurotransmitter in the carotid body of several animal species and its functional role at the level of peripheral arterial chemoreflex pathway is attributed to the presence of the dopamine D2-receptors. We present evidence that the dopamine D1-receptor mRNA is also expressed in the carotid body of ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00033-9
更新日期:1998-06-01 00:00:00
abstract::We carried out voltage-sensitive dye imaging of the guinea pig auditory cortex to determine whether the ongoing and spontaneous activities of the cortex exhibit spatial coherence reflecting the tonotopic organization of the cortex. We used independent component analysis and a signal-plus-noise model to extract ongoing...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.01.007
更新日期:2008-05-01 00:00:00
abstract::The magnitude of long-term potentiation (LTP) was re-examined for monosynaptic transmission between mossy fibers and CA3 neurons in thin sections of the hippocampus of the guinea pig. Although an initial negative deflection in the field potential showed apparent short-term potentiation, this deflection was concluded t...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90060-x
更新日期:1986-09-01 00:00:00
abstract::A disynaptic projection from the spinal cord to the striatum was observed in the rat light and electron microscopically. An anterograde tracer, wheat germ agglutinin conjugated to horseradish peroxidase was injected into the ventral gray matter of the upper cervical spinal cord, and a retrograde tracer, biotinylated d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.05.009
更新日期:2006-09-01 00:00:00
abstract::The effects of 5-HT3-receptor-related agents on long-term potentiation (LTP) in the mossy fiber-CA3 system were studied in guinea pig hippocampal slices. 5-HT3 receptor agonists, 1-(m-chlorophenyl)-biguanide (mCPBG) and 2-methyl serotonin (2-Me-5-HT) significantly attenuated the magnitude of LTP of the population spik...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(94)90163-5
更新日期:1994-01-01 00:00:00