Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic substrates.

abstract：:We previously reported that the gamma gamma-isozyme of enolase, NSE), one of the glycolytic enzymes, promoted the survival of embryonic rat neocortical neurons in culture, but alpha alpha-isozyme (non-neuronal enolase) had no effect. In the present study, the neurotrophic effects of NSE on cultured mesencephalic and s...

journal_title：Neuroscience research

authors： Hattori T,Takei N,Mizuno Y,Kato K,Kohsaka S

更新日期：1995-01-01 00:00:00

abstract：:Most imaging studies of the enteric nervous system (ENS) that regulates the function of the gastrointestinal tract are so far performed using preparations isolated from animals, thus hindering the understanding of the ENS function in vivo. Here we report a method for imaging the ENS cellular network activity in living...

journal_title：Neuroscience research

authors： Motegi Y,Sato M,Horiguchi K,Ohkura M,Gengyo-Ando K,Ikegaya Y,Fusamae Y,Hongo Y,Suzuki M,Ogawa K,Takaki M,Nakai J

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD). METHOD:EEGs were recorded from 22 AD patients and 23 age-matched healthy...

journal_title：Neuroscience research

authors： Park YM,Che HJ,Im CH,Jung HT,Bae SM,Lee SH

更新日期：2008-10-01 00:00:00

abstract：:Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Chicken Bsg (HT7/neurothelin/ 5A11) is expressed in neuroblasts, but disappears from neurons after a specific stage of cytodifferentiation, and becomes restrictedly expressed in the capillary endothelium in the adult brain. We s...

journal_title：Neuroscience research

authors： Fan QW,Yuasa S,Kuno N,Senda T,Kobayashi M,Muramatsu T,Kadomatsu K

更新日期：1998-01-01 00:00:00

abstract：:Changes in levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) in various regions of the rat brain following kainic acid-induced seizure activity were investigated. BDNF protein, as measured by a two-site enzyme immunoassay, increased transiently 12-24 h after the in...

journal_title：Neuroscience research

authors： Katoh-Semba R,Takeuchi IK,Inaguma Y,Ito H,Kato K

更新日期：1999-10-01 00:00:00

abstract：:Dynamic properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic response (OKR) were studied in mice. The VOR was examined in the dark (VORD), in the light (VORL) and in the condition in which most of the visual field moves synchronously with the head motion (VORF). A mouse and/or a surrounding screen wi...

journal_title：Neuroscience research

authors： Iwashita M,Kanai R,Funabiki K,Matsuda K,Hirano T

更新日期：2001-03-01 00:00:00

abstract：:Since the first analysis of the Drosophila courtship song more than 50 years ago, the molecular and neural mechanisms underlying the acoustic communication between fruit flies has been studied extensively. The results of recent studies utilizing a wide array of genetic tools provide novel insights into the anatomic an...

journal_title：Neuroscience research

authors： Kamikouchi A

更新日期：2013-07-01 00:00:00

abstract：:The subiculum is one of output structures of the hippocampal formation and plays a pivotal role in learning and memory. Because its morphological features are less investigated than those of the hippocampus proper, we explored the internal structure of the rat subiculum using immunohistochemistry. The septal subiculum...

journal_title：Neuroscience research

authors： Ishihara Y,Fukuda T,Sato F

更新日期：2020-01-01 00:00:00

abstract：:Single units of the adrenal sympathetic nerve (n = 46) were dissected and characterized with respect to tonic discharge and response to cutaneous and baroreceptor stimulation. The frequency of tonic discharge averaged 1.6 Hz and cardiovascular rhythmic modulation was observed in 53% of the units. The stimuli employed ...

journal_title：Neuroscience research

authors： Ito K,Sato A,Shimamura K,Swenson RS

更新日期：1984-04-01 00:00:00

abstract：:The magnitude of long-term potentiation (LTP) was re-examined for monosynaptic transmission between mossy fibers and CA3 neurons in thin sections of the hippocampus of the guinea pig. Although an initial negative deflection in the field potential showed apparent short-term potentiation, this deflection was concluded t...

journal_title：Neuroscience research

authors： Higashima M,Yamamoto C

更新日期：1986-09-01 00:00:00

abstract：:The DYT1 gene containing a trinucleotide deletion (DeltaGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded...

journal_title：Neuroscience research

authors： Dang MT,Yokoi F,Pence MA,Li Y

更新日期：2006-12-01 00:00:00

abstract：:In order to investigate temporal characteristics of oscillatory neural activity and the effect of chronic dopamine depletion on it, local field potentials were measured in anesthetized rats without or with a 6-OHDA lesion at either the ventral tegmental area or the substantia nigra compacta, using a pair of electrodes...

journal_title：Neuroscience research

authors： Lee KM,Ahn TB,Jeon BS,Kim DG

更新日期：2004-06-01 00:00:00

abstract：:Mature rat spinal cord cDNA libraries constructed in lambda gt10 and lambda ZAPII were screened with an oligonucleotide probe (39 mer), and 4 clones that possess DNA-inserts encoding a glycine receptor subunit were obtained. The cloned cDNAs were used to reconstruct the nucleotide sequence of the full-length open read...

journal_title：Neuroscience research

authors： Akagi H,Hirai K,Hishinuma F

更新日期：1991-06-01 00:00:00

abstract：:Given the amygdala's role in survival mechanisms, and its pivotal contributions to psychological processes, it is no surprise that it is one of the most well-studied brain regions. One of the common methods for understanding the functional role of the amygdala is the use of functional magnetic resonance imaging (fMRI)...

journal_title：Neuroscience research

authors： Murphy JE,Yanes JA,Kirby LAJ,Reid MA,Robinson JL

更新日期：2020-01-01 00:00:00

abstract：:Medial preoptic area (MPA), supraoptic nucleus (SON), magnocellular (MaPVN) and parvocellular (PaPVN) paraventricular hypothalamic nuclei, and mesencephalic lateral tegmentum (MLT) are involved in maternal behavior, parturition and lactation. This study investigated the FosB and Fos immunoreactivity in these regions o...

journal_title：Neuroscience research

authors： Lin SH,Miyata S,Weng W,Matsunaga W,Ichikawa J,Furuya K,Nakashima T,Kiyohara T

更新日期：1998-12-01 00:00:00

abstract：:The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was gi...

journal_title：Neuroscience research

authors： Terasawa H,Hirai T,Ninomiya T,Ikeda Y,Ishijima T,Yajima T,Hamaue N,Nagase Y,Kang Y,Minami M

更新日期：2002-08-01 00:00:00

abstract：:Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are g...

journal_title：Neuroscience research

authors： Yamaguchi Y

更新日期：2018-04-01 00:00:00

abstract：:Gene targeting to disrupt gene expression in a temporal and spatial manner in a specific tissue using Cre recombinase-mediated gene inactivation has been proven to be useful to study in vivo gene function. To delete genes specifically in neurons during the late phase of brain development, we have generated transgenic ...

journal_title：Neuroscience research

authors： Hirasawa M,Cho A,Sreenath T,Sauer B,Julien JP,Kulkarni AB

更新日期：2001-06-01 00:00:00

abstract：:The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...

journal_title：Neuroscience research

authors： Tsuchiya D,Kitamura Y,Takata K,Sugisaki T,Taniguchi T,Uemura K,Miki H,Takenawa T,Shimohama S

更新日期：2006-12-01 00:00:00

abstract：:To investigate the effect of abrupt or non-abrupt isolation stress on the classical conditioned histamine release, socially isolated or paired guinea pigs underwent conditioning procedures in which ovalbumin (OA) as an unconditioned stimulus (US) and dimethylsulfide (sulfur smelling) as a conditioned stimulus (CS) wer...

journal_title：Neuroscience research

authors： Irie M,Nagata S,Endo Y

更新日期：2002-09-01 00:00:00

abstract：:Alzheimer's disease (AD) patients tend to have increased plasma levels of homocysteine. However, it is unclear whether abnormality in homocysteine levels is a primary cause of Alzheimer's disease or a disease marker. In order to investigate the relative impact of Alzheimer's disease on plasma homocysteine levels, tota...

journal_title：Neuroscience research

authors： Santiard-Baron D,Aupetit J,Janel N

更新日期：2005-12-01 00:00:00

abstract：:Concurrent eye and hand movements toward a common visual target require different motor programs based on identical visual input. We used event-related brain potentials (ERP) to determine if and when the processing of the visual target differs for the two motor systems. The N2, an index for target evaluation, was more...

journal_title：Neuroscience research

authors： Wehrspaun CC,Pfabigan DM,Sailer U

更新日期：2013-09-01 00:00:00

abstract：:Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). CO is generated by heme oxygenase during the conversion of heme to biliverdin. In this study, we raised an antiserum against the ...

journal_title：Neuroscience research

authors： Yamanaka M,Yamabe K,Saitoh Y,Katoh-Semba R,Semba R

更新日期：1996-03-01 00:00:00

abstract：:The purpose of this study was to investigate electrophysiological correlates related to the recognition of repeated faces in the intact human by means of event-related brain potentials (ERPs). A group of young healthy adults performed a continuous face recognition task, in which 240 unfamiliar faces were flashed upon ...

journal_title：Neuroscience research

authors： Münte TF,Brack M,Grootheer O,Wieringa BM,Matzke M,Johannes S

更新日期：1997-07-01 00:00:00

abstract：:The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...

journal_title：Neuroscience research

authors： Sun S,Ohta A,Kuhara A,Nishikawa Y,Kage-Nakadai E

更新日期：2020-01-01 00:00:00

abstract：:Area TE sends dense projections to the perirhinal cortex in macaque monkeys, an area in which we previously observed flexible signals regarding upcoming reward outcomes during a conditional-association cued-reward task. To investigate neuronal processing during the generation of information on upcoming reward outcomes...

journal_title：Neuroscience research

authors： Ohyama K,Sugase-Miyamoto Y,Matsumoto N,Sato C,Shidara M

更新日期：2014-11-01 00:00:00

abstract：:Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane...

journal_title：Neuroscience research

authors： Furukawa K,Onodera H,Kogure K,Akaike N

更新日期：1993-02-01 00:00:00

abstract：:The structure of dendritic spines determines synaptic efficacy, a plastic process that mediates information processing in the vertebrate nervous system. Aberrant spine morphology, including alterations in shape, size, and number, are common in different brain diseases. Because of this, accurate and unbiased characteri...

journal_title：Neuroscience research

authors： Maiti P,Manna J,McDonald MP

更新日期：2015-07-01 00:00:00

abstract：:Motor imagery (MI) is a mental practice that reproduces the visual- and/or kinesthetic-modality brain activations accompanying movement. It is a useful rehabilitation technique as the affected motor cortex can be stimulated in patients with stroke and hemiplegia. However, most patients with stroke have difficulty with...

journal_title：Neuroscience research

authors： Tani M,Ono Y,Matsubara M,Ohmatsu S,Yukawa Y,Kohno M,Tominaga T

更新日期：2018-08-01 00:00:00

abstract：:Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal lev...

journal_title：Neuroscience research

authors： Koike T,Kan S,Misaki M,Miyauchi S

更新日期：2011-04-01 00:00:00