Abstract:
:Nerve growth factor (NGF)-like immunoreactivity was demonstrated in the rat pituitary intermediate lobe by indirect immunofluorescence method using antisera specific to beta-NGF isolated from adult male mouse submaxillary salivary gland. Co-culture of frozen or fresh intermediate lobes with newborn rat superior cervical ganglion resulted in marked fiber growth from the ganglion, which was totally inhibited by NGF antiserum, suggesting the presence in situ and secretion in vitro of biologically active pituitary NGF. Pituitary stalk transection caused decrease in both the NGF immunoreactivity and biological activity. These findings suggest that pituitary NGF level is under neural regulation.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Soinila S,Lakshmanan J,Lahtinen Tdoi
10.1016/0168-0102(88)90014-4subject
Has Abstractpub_date
1988-12-01 00:00:00pages
123-30issue
2eissn
0168-0102issn
1872-8111pii
0168-0102(88)90014-4journal_volume
6pub_type
杂志文章abstract::Mature rat spinal cord cDNA libraries constructed in lambda gt10 and lambda ZAPII were screened with an oligonucleotide probe (39 mer), and 4 clones that possess DNA-inserts encoding a glycine receptor subunit were obtained. The cloned cDNAs were used to reconstruct the nucleotide sequence of the full-length open read...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90064-6
更新日期:1991-06-01 00:00:00
abstract::To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.01.005
更新日期:2005-05-01 00:00:00
abstract::The responses of slice-cultured Purkinje cells to trans-DL-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD) were examined by intracellular recording techniques and fura-2 microfluorometry. Bath-application of t-ACPD (100 microM, 30 s), a selective agonist of metabotropic glutamate receptors (mGluRs), to Purkinje cel...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(93)90125-a
更新日期:1993-03-01 00:00:00
abstract::The present study investigated the effect of nicotine exposure on gustatory plasticity in the nematode Caenorhabditis elegans. The chemotactic response of wild-type N2 nematodes pre-exposed to 100mM NaCl with 3.0mM nicotine was almost the same as that of mock-conditioned nematodes unexposed to NaCl; however, the respo...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2013.09.001
更新日期:2013-11-01 00:00:00
abstract::Sizes of neuronal somata in the cat cervical dorsal root ganglia were determined at different levels (C1-C8). The average value and class distribution of mean cell diameter were analyzed. The ganglia from C1 to C5 could be clearly distinguished from those at levels of brachial plexus afferents (C6-C8) with respect to ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(90)90009-4
更新日期:1990-02-01 00:00:00
abstract::Nandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal gro...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.09.001
更新日期:2020-09-01 00:00:00
abstract::The interaction of neurotransmitter receptors with the underlying cytoskeleton via subsynaptic proteins is an important mechanism for the targeting of the receptors to synapses in the central nervous system. We show that delta glutamate receptors (delta receptors), expressed predominantly in the dendritic spines of ce...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(99)00061-9
更新日期:1999-09-01 00:00:00
abstract::Electromyograms were recorded from the intralaryngeal muscles (the posterior cricoarytenoid (PCA) and thyroarytenoid (TA) muscles) and the ventilatory muscles (the diaphragm (DA) and abdominal (RA) muscle) during electrically induced vocalization in precollicular postmammillary decerebrate cats. Electrical stimulation...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(93)90032-l
更新日期:1993-06-01 00:00:00
abstract::Human's sophisticated motor learning system paradoxically interferes with motor performance when visual information is mirror-reversed (MR), because normal movement error correction further aggravates the error. This error-increasing mechanism makes performing even a simple reaching task difficult, but is overcome by ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2014.12.010
更新日期:2015-05-01 00:00:00
abstract::Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26...
journal_title:Neuroscience research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0168-0102(01)00310-8
更新日期:2002-02-01 00:00:00
abstract::In the present study, the ability of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in the hippocampus to enhance locomotor activity in rats was investigated by local infusion. Intraperitoneal injection of the selective 5-HT(2C) antagonist SB 242084 (1 mg/kg) significantly increased rats motor activity, while the effect...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00215-2
更新日期:2001-05-01 00:00:00
abstract::Utilizing slice preparations of GAD67-GFP knock-in mouse, in which GABAergic neurons are specifically labeled with GFP fluorescence, we studied electrophysiological characteristics of GABAergic neurons of IC by whole-cell patch clamp-recording combined with biocytin-intracellular-staining techniques. GABAergic neurons...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.12.019
更新日期:2005-04-01 00:00:00
abstract::We have generated a transgenic mouse model in which astrocytes express an enhanced green fluorescent protein (EGFP) under the control of the mouse glial fibrillary acidic protein (GFAP) promoter. EGFP, which is characteristically found throughout the cell, was expressed in these animals even in astrocytic fine process...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2003.08.008
更新日期:2003-12-01 00:00:00
abstract::Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2014.02.003
更新日期:2014-04-01 00:00:00
abstract::In lightly alpha-chloralose anaesthetized cats, activity was recorded simultaneously from 2-4 primary muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles. Increased tension in medial or lateral collateral ligament was found to evoke changes in the responses of the primary spi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90066-8
更新日期:1991-06-01 00:00:00
abstract::Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO). Hamster SCO consists of the ependymal and hypendymal cell layers, the latter being arranged as ro...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00185-8
更新日期:2003-09-01 00:00:00
abstract::The present study was performed to determine whether the voltage gated Cl- channel (CLC) expression is altered in the hippocampus of seizure sensitive (SS) gerbils, and to identify the strong fast paired-pulse inhibition in the dentate gyrus of SS gerbils is associated with altered CLC expression. In the hippocampal p...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.09.010
更新日期:2005-01-01 00:00:00
abstract::The purposes of the present study were to determine which upper airway movements cause a difference in the expiratory airflow pathway between sneezing and coughing, and to develop a new animal model for studying the neural mechanism of sneezing in paralyzed animals, i.e. fictive sneezing. We compared the upper airway ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00075-3
更新日期:1998-10-01 00:00:00
abstract::Chemokines are a family of peptides originally identified as the factors regulating the migration of leukocytes in inflammatory and immune responses. Recently, they have been shown to be produced in the central and peripheral nervous systems under various pathological conditions and act on neuronal and glial cells. In...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.01.004
更新日期:2004-04-01 00:00:00
abstract::Alcoholism is a psychiatric condition that develops through neuroadaptations in response to neuronal stresses caused by chronic ethanol intake. Neurons can adapt to ethanol-induced metabolic changes by activating cellular protective mechanisms, including autophagy. Here we show that expression of Ulk1, a gene critical...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2016.12.004
更新日期:2017-04-01 00:00:00
abstract::Education involves learning new information and acquiring cognitive skills. These require various cognitive processes including learning, memory, and language. Since cognitive processes activate associated brain areas, we proposed that the brains of elderly people with longer education periods would show traces of rep...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2014.12.009
更新日期:2015-05-01 00:00:00
abstract::The Madagascan lesser hedgehog tenrec was investigated to get insight into the areal evolution of the hippocampal formation in mammals with poorly differentiated brains. The hippocampal subdivisions were analyzed using cyto- and chemoarchitectural criteria; long associational and commissural connections were demonstra...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00288-7
更新日期:2001-11-01 00:00:00
abstract::l-Serine is required for the synthesis of glycine and d-serine, both of which are NMDA receptor co-agonists. Although roles for d-serine and glycine have been suggested in schizophrenia, little is known about the role of the l-serine synthesizing cascade in schizophrenia or related psychiatric conditions. Here we repo...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.10.003
更新日期:2011-02-01 00:00:00
abstract::The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine s...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2013.02.002
更新日期:2013-04-01 00:00:00
abstract::Lateral (L) and medial (M) midbrain astrocytes differ in their ability to support neuritic growth (L, permissive; M, non-permissive) with properties of M glia depending on heparan sulfate (HS). Here we show by atomic force microscopy that the surfaces of formaldehyde-fixed astrocytes differ by conspicuous 250 nm protr...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(00)00159-0
更新日期:2000-10-01 00:00:00
abstract::The structure of dendritic spines determines synaptic efficacy, a plastic process that mediates information processing in the vertebrate nervous system. Aberrant spine morphology, including alterations in shape, size, and number, are common in different brain diseases. Because of this, accurate and unbiased characteri...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2015.02.007
更新日期:2015-07-01 00:00:00
abstract::In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00897-2
更新日期:1995-05-01 00:00:00
abstract::Huntington's disease (HD) is an autosomal dominant inheritable neurodegenerative disorder currently without effective treatment. It is caused by an expanded polyglutamine (poly Q) tract in the corresponding protein, huntingtin (htt), and therefore suppressing the huntingtin expression in brain neurons is expected to d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.06.021
更新日期:2005-11-01 00:00:00
abstract::Adult mammals could spontaneously achieve a partial sensory-motor recovery after spinal cord injury, by mechanisms including synaptic plasticity. We previously showed that this recovery is associated to the expression of synapsin-I, and that sonic hedgehog and Notch-1 could be also involved in plasticity. The role of ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.04.010
更新日期:2012-07-01 00:00:00
abstract::Amyloid-beta (Aβ) peptides, Aβ 1-42 (Aβ42) and Aβ43 in particular, cause neurotoxicity and cell death in the brain of Alzheimer's disease (AD) at higher concentrations. Carnosic acid (CA), a phenolic diterpene compound in the labiate herbs rosemary and sage, serves as an activator for neuroprotective and neurotrophic ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2014.12.003
更新日期:2015-05-01 00:00:00