Nerve growth factor-like activity in the rat pituitary intermediate lobe.

Abstract:

:Nerve growth factor (NGF)-like immunoreactivity was demonstrated in the rat pituitary intermediate lobe by indirect immunofluorescence method using antisera specific to beta-NGF isolated from adult male mouse submaxillary salivary gland. Co-culture of frozen or fresh intermediate lobes with newborn rat superior cervical ganglion resulted in marked fiber growth from the ganglion, which was totally inhibited by NGF antiserum, suggesting the presence in situ and secretion in vitro of biologically active pituitary NGF. Pituitary stalk transection caused decrease in both the NGF immunoreactivity and biological activity. These findings suggest that pituitary NGF level is under neural regulation.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Soinila S,Lakshmanan J,Lahtinen T

doi

10.1016/0168-0102(88)90014-4

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

123-30

issue

2

eissn

0168-0102

issn

1872-8111

pii

0168-0102(88)90014-4

journal_volume

6

pub_type

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