Super-oxide anion production and antioxidant enzymatic activities associated with the executive functions in peripheral blood mononuclear cells of healthy adult samples.

Abstract:

:Executive Functions (EFs) involve a set of high cognitive abilities impairment which have been successfully related to a redox omeostasis imbalance in several psychiatric disorders. Firstly, we aimed to investigate the relationship between executive functioning and some oxidative metabolism parameters in Peripheral Blood Mononuclear Cells (PBMCs) from healthy adult samples. The Brown Attention-Deficit Disorder Scales were administered to assess five specific facets of executive functioning. Total superoxide anion production, Super Oxide Dismutase (SOD), Catalase (CAT), Glutathione Reductase (GR) and Glutathione Peroxidase (GPx) activities were evaluated on proteins extracted from the PBMCs. We found significant positive correlations between superoxide anion production and the total score of the 'Brown' Scale and some of its clusters. The GPx and CAT activities were negatively associated with the total score and some clusters. In a linear regression analysis, these biological variables were indicated as the most salient predictors of the total score, explaining the 24% variance (adjusted R(2)=0.24, ANOVA, p<.001). This study provides novel evidence that Executive Functions have underpinnings in the oxidative metabolism, as ascertained in healthy subjects.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Pesce M,Rizzuto A,La Fratta I,Tatangelo R,Campagna G,Iannasso M,Ferrone A,Franceschelli S,Speranza L,Patruno A,De Lutiis MA,Felaco M,Grilli A

doi

10.1016/j.neures.2015.11.007

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

23-8

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(15)00287-4

journal_volume

106

pub_type

杂志文章
  • Proline repeats, in cis- and trans-positions, confer protection against the toxicity of misfolded proteins in a mammalian cellular model.

    abstract::A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2011.05.001

    authors: Siwach P,Sengupta S,Parihar R,Ganesh S

    更新日期:2011-08-01 00:00:00

  • Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus.

    abstract::We investigated the distribution and colocalization pattern of the two corticosteroid receptors, mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), in the hippocampus and hypothalamus, the main target regions of corticosterone in the rat brain, using double immunofluorescence histochemistry in conjuncti...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2004.12.013

    authors: Han F,Ozawa H,Matsuda K,Nishi M,Kawata M

    更新日期:2005-04-01 00:00:00

  • Event-related potentials during an auditory discrimination task in rats.

    abstract::Event-related potentials (ERPs) during an auditory discrimination task were recorded both on the surface and at a depth of the auditory cortex in rats. Ten-kilohertz rare and 5-kHz frequent tones were used with the probabilities of 0.2 and 0.8. Lever pressing within 2 s, following the onset of the rare tone, was rewar...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(94)90073-6

    authors: Iwanami A,Shinba T,Sumi M,Ozawa N,Yamamoto K

    更新日期:1994-11-01 00:00:00

  • Hypnotic suggestion alters the state of the motor cortex.

    abstract::Hypnosis often leads people to obey a suggestion of movement and to lose perceived voluntariness. This inexplicable phenomenon suggests that the state of the motor system may be altered by hypnosis; however, objective evidence for this is still lacking. Thus, we used transcranial magnetic stimulation of the primary mo...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2014.05.009

    authors: Takarada Y,Nozaki D

    更新日期:2014-08-01 00:00:00

  • Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive degeneration of motoneurons. We have demonstrated that hepatocyte growth factor (HGF) attenuates loss of both spinal and brainstem motoneurons of ALS model mice expressing mutated human SOD1(G93A) (G93A). This study was designed to ass...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.06.016

    authors: Kadoyama K,Funakoshi H,Ohya-Shimada W,Nakamura T,Matsumoto K,Matsuyama S,Nakamura T

    更新日期:2009-10-01 00:00:00

  • Interaction between paired-pulse facilitation and long-term potentiation in the projection from hippocampal area CA1 to the entorhinal cortex.

    abstract::The hippocampus communicates with the neocortex via the entorhinal cortex and is thought to be critically involved in the consolidation of memories. This paper contains in vivo evidence of a projection from the hippocampal area CA1 to the entorhinal cortex. Current theories of memory formation suggest that the backpro...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2005.06.009

    authors: Craig S,Commins S

    更新日期:2005-10-01 00:00:00

  • Ingroup favoritism or the black sheep effect: Perceived intentions modulate subjective responses to aggressive interactions.

    abstract::Social categorization plays an important role in provoking the victim's responses to aggressive interactions. Pioneering studies suggested that uncertainty in the perpetrator's hostile intention influences whether ingroup favoritism or the black sheep effect (ingroup strictness) will be manifested to a greater extent....

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2016.01.011

    authors: Wang L,Zheng J,Meng L,Lu Q,Ma Q

    更新日期:2016-07-01 00:00:00

  • The use of fish models to study human neurological disorders.

    abstract::Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2017.02.004

    authors: Matsui H

    更新日期:2017-07-01 00:00:00

  • Menstrual and circadian variations in time perception in healthy women and women with premenstrual syndrome.

    abstract::A time production test was performed in seven normal females and seven females with premenstrual syndrome (PMS). We used a time production test for six time intervals (6, 12, 24, 36, 48, 60 s). Time production tests were performed at 08:00, 14:00 and 20:00 h in the follicular, early luteal and late luteal phases (LLP)...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(01)00290-5

    authors: Morofushi M,Shinohara K,Kimura F

    更新日期:2001-12-01 00:00:00

  • Corticotropin releasing factor and galanin-containing neurons projecting to the median eminence of the rat.

    abstract::To identify corticotropin releasing factor (CRF)- and galanin (GAL)-containing neurons projecting to the median eminence, a retrograde tracing method with True blue was combined with a double-staining method. It was demonstrated that some True blue-labeled CRF neurons in the paraventricular nucleus were also immunorea...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(92)90073-l

    authors: Niimi M,Takahara J,Kawanishi K

    更新日期:1992-09-01 00:00:00

  • Neuroanatomical and neurochemical organization of projections from the central amygdaloid nucleus to the nucleus retroambiguus via the periaqueductal gray in the rat.

    abstract::The periaqueductal gray (PAG)-nucleus retroambiguus (NRA) pathway has been known to be involved in the control of vocalization and sexual behavior. To know how the amygdaloid complex influences the PAG-NRA pathway, here we first examined the synaptic organization between the central amygdaloid nucleus (CeA) fibers and...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2008.10.004

    authors: Oka T,Tsumori T,Yokota S,Yasui Y

    更新日期:2008-12-01 00:00:00

  • Long-term enhancement of excitatory synaptic inputs to layer V parahippocampal neurons by low frequency stimulation in rat brain slices.

    abstract::Excitatory inputs to layer V neurons of the parasubiculum and medial entorhinal cortex were examined in rat brain slices with intracellular and field potential recordings. Single extracellular stimuli to layer V evoked subthreshold excitatory postsynaptic potentials (EPSPs) or a long duration (>100 ms) depolarization ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(01)00306-6

    authors: Funahashi M,Matsuo R,Stewart M

    更新日期:2002-01-01 00:00:00

  • Probing the function of neuronal populations: combining micromirror-based optogenetic photostimulation with voltage-sensitive dye imaging.

    abstract::Recent advances in our understanding of brain function have come from using light to either control or image neuronal activity. Here we describe an approach that combines both techniques: a micromirror array is used to photostimulate populations of presynaptic neurons expressing channelrhodopsin-2, while a red-shifted...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2012.11.006

    authors: Tsuda S,Kee MZ,Cunha C,Kim J,Yan P,Loew LM,Augustine GJ

    更新日期:2013-01-01 00:00:00

  • An electrochemical microprobe for detecting nitric oxide release in brain tissue.

    abstract::To detect the release of nitric oxide (NO) in brain tissue, an electrochemical microprobe was developed. The output current of the probe correlated linearly with the NO concentration at the tip, and the sensitivity of the probe was between 3.5 and 106 pA per 1 microM change in NO concentration. This probe showed no se...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(90)90048-j

    authors: Shibuki K

    更新日期:1990-09-01 00:00:00

  • Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity.

    abstract::The current study evidenced hypothesis that mitochondrial dysfunction-oxidative stress-dependent apoptotic pathways play a critical role in degeneration of dopaminergic neurons in Parkinson's disease. Model of rotenone-induced parkinsonism in rats produced decrease in striatal complex I activity and reduced glutathion...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2011.08.008

    authors: Abdin AA,Sarhan NI

    更新日期:2011-12-01 00:00:00

  • Activities of the intralaryngeal muscles during electrically induced vocalization in decerebrate cats.

    abstract::Electromyograms were recorded from the intralaryngeal muscles (the posterior cricoarytenoid (PCA) and thyroarytenoid (TA) muscles) and the ventilatory muscles (the diaphragm (DA) and abdominal (RA) muscle) during electrically induced vocalization in precollicular postmammillary decerebrate cats. Electrical stimulation...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(93)90032-l

    authors: Yamanaka Y,Sakamoto T,Wada K,Nakajima Y

    更新日期:1993-06-01 00:00:00

  • Confocal and multiphoton calcium imaging of the enteric nervous system in anesthetized mice.

    abstract::Most imaging studies of the enteric nervous system (ENS) that regulates the function of the gastrointestinal tract are so far performed using preparations isolated from animals, thus hindering the understanding of the ENS function in vivo. Here we report a method for imaging the ENS cellular network activity in living...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2019.02.004

    authors: Motegi Y,Sato M,Horiguchi K,Ohkura M,Gengyo-Ando K,Ikegaya Y,Fusamae Y,Hongo Y,Suzuki M,Ogawa K,Takaki M,Nakai J

    更新日期:2020-02-01 00:00:00

  • Excitatory synapse in the rat hippocampus in tissue culture and effects of aniracetam.

    abstract::Excitatory synaptic connections between rat hippocampal neurons were established in tissue culture. The electrophysiological and pharmacological properties of these synapses were studied with the use of the tight-seal whole-cell recording technique. The excitatory postsynaptic current (EPSC) in a dissociated CA1 neuro...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(91)90101-4

    authors: Ozawa S,Iino M,Abe M

    更新日期:1991-10-01 00:00:00

  • Intracellular Ca2+-dependent and Ca2+-independent responses of rat brain serotonin receptors transplanted to Xenopus oocytes.

    abstract::Xenopus oocytes injected with messenger RNA extracted from rat brain are induced to acquire a variety of neurotransmitter receptors and voltage-operated membrane channels. Activation of the receptors to serotonin, acetylcholine (muscarinic) and glutamate elicits oscillatory membrane currents carried by chloride ions. ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(85)90021-5

    authors: Parker I,Gundersen CB,Miledi R

    更新日期:1985-08-01 00:00:00

  • Glial cell line-derived neurotrophic factor enhances survival of GM-CSF dependent rat GMIR1-microglial cells.

    abstract::Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(02)00036-6

    authors: Salimi K,Moser K,Zassler B,Reindl M,Embacher N,Schermer C,Weis C,Marksteiner J,Sawada M,Humpel C

    更新日期:2002-07-01 00:00:00

  • Antisense hippocampal knockdown of NMDA-NR1 by HVJ-liposome vector induces deficit of prepulse inhibition but not of spatial memory.

    abstract::Considerable evidence suggests that an N-methyl-D-aspartate (NMDA) receptor plays a crucial role in memory and cognitive function. To identify the role of this receptor in higher functions of the brain, we delivered antisense oligonucleotides against an NMDA-NR1 subunit (NR1) to the hippocampus in rats using the HVJ-l...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(03)00012-9

    authors: Inada K,Ishigooka J,Anzai T,Suzuki E,Miyaoka H,Saji M

    更新日期:2003-04-01 00:00:00

  • Zinc ion enhances the blocking potency of synthetic analogs of spider toxin (JSTX) on the glutamate receptor.

    abstract::The effect of synthetic spider toxin analogs containing aza-crown in combination with zinc and copper was studied on the lobster neuromuscular synapse. The suppressive action of N4-type spider toxin analog (N4) on excitatory postsynaptic potentials (EPSPs) was markedly enhanced in the presence of 10(-5)-10(-4) M Zn2+....

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(89)90028-x

    authors: Kawai N,Miwa A,Hashimoto Y,Shudo K,Asami T,Nakajima T

    更新日期:1989-04-01 00:00:00

  • Anisotropic spatial coherence of ongoing and spontaneous activities in auditory cortex.

    abstract::We carried out voltage-sensitive dye imaging of the guinea pig auditory cortex to determine whether the ongoing and spontaneous activities of the cortex exhibit spatial coherence reflecting the tonotopic organization of the cortex. We used independent component analysis and a signal-plus-noise model to extract ongoing...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2008.01.007

    authors: Yoshida T,Sakagami M,Katura T,Yamazaki K,Tanaka S,Iwamoto M,Tanaka N

    更新日期:2008-05-01 00:00:00

  • Area dependent expression of ZNF312 in human fetal cerebral cortex.

    abstract::The human cerebral neocortex is divided into six layers consisting of specific neuronal cell types and connections. To determine the distribution of cortical neurons during early development, we examined the expressions of layer-specific markers in human midterm fetal brains. Layer V marker ZNF312 is expressed in most...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2010.05.007

    authors: Zhu H,Yang Y,Gao J,Tao H,Qu C,Qu J,Chen J

    更新日期:2010-09-01 00:00:00

  • Neuronal connections between the auricular skin and the sympathetic pre- and postganglionic neurons of the dog as studied by using pseudorabies virus.

    abstract::Pseudorabies virus (PrV) as a neuronal tracer was microinjected into the concave surface of the puppy's left pinna to establish the morphological basis of somato-visceral linkage. The virus infected neurons were detected by FITC conjugated with polyclonal swine anti-PrV serum. Labelled neurons were localized in: (1) t...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)00129-6

    authors: Chien CH,Shieh JY,Liao MH,Ling EA,Wen CY

    更新日期:1998-02-01 00:00:00

  • Fractal dimension of dendritic tree of cerebellar Purkinje cell during onto- and phylogenetic development.

    abstract::The cerebellar Purkinje cell has highly branched dendrites extending in a transverse plane to the cerebellar folium. Branching patterns of the dendrites were subjected to fractal analysis to obtain a quantitative measure of their intricacy. Using a square-covering method, we found that dendrites have a statistical sel...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(92)90031-7

    authors: Takeda T,Ishikawa A,Ohtomo K,Kobayashi Y,Matsuoka T

    更新日期:1992-02-01 00:00:00

  • Effects of nocturnal bright light on saliva melatonin, core body temperature and sleep propensity rhythms in human subjects.

    abstract::Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26...

    journal_title:Neuroscience research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0168-0102(01)00310-8

    authors: Kubota T,Uchiyama M,Suzuki H,Shibui K,Kim K,Tan X,Tagaya H,Okawa M,Inoue S

    更新日期:2002-02-01 00:00:00

  • Zinc ion as modulator effects on excitability and synaptic transmission in hippocampal CA1 neurons in Wistar rats.

    abstract::Zinc is one of trace elements that play essential roles in several cell functions, and is unquestionably important to the normal health and function of the central nervous system. Growing evidence suggests that Zn(2+) can become a pathogenic agent in certain neurological disease states, such as ischemia, seizures, and...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2010.07.2030

    authors: Tian Y,Yang Z,Zhang T

    更新日期:2010-11-01 00:00:00

  • Changes in properties of neuronal responses in two cortical taste areas in rats of various ages.

    abstract::Changes in the features of responses of cortical taste neurons were studied in granular insular (GI) and dysgranular insular (DI) areas of urethane-anesthetized SD rats of four age groups (4-10, 14-20, 25-35 and > 90 days). Stimuli included four basic taste stimuli, 0.1 M NH4Cl, and the water extract of a food pellet,...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(94)90082-5

    authors: Ogawa H,Hasegawa K,Ohgushi M,Murayama N

    更新日期:1994-06-01 00:00:00

  • Input-output organization of the rostral part of the dorsal premotor cortex, with special reference to its corticostriatal projection.

    abstract::Until recently, little was known about the rostral part of the dorsal premotor cortex (PMdr). In the present study, somatotopical representations of the PMdr were electrophysiologically identified in the macaque monkey, and the distribution of corticostriatal input from the forelimb region of the PMdr was analyzed in ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2003.09.006

    authors: Tachibana Y,Nambu A,Hatanaka N,Miyachi S,Takada M

    更新日期:2004-01-01 00:00:00