Molecular mechanism for trimetric G protein-coupled thermosensation and synaptic regulation in the temperature response circuit of Caenorhabditis elegans.

abstract：:L-3,4-Dihydroxyphenylalanine (DOPA) has been believed to be a precursor of dopamine, and itself being an inert amino acid. Previously, we have proposed DOPA as a neurotransmitter candidate in the central nervous system (CNS). Recent findings have suggested DOPA as an endogenous agonist of a G-protein coupled receptor,...

journal_title：Neuroscience research

authors： Masukawa D,Nakamura F,Koga M,Kamiya M,Chen S,Yamashita N,Arai N,Goshima Y

更新日期：2014-11-01 00:00:00

abstract：:We examined the effects of the odors from mother's milk, other mother's milk and formula milk on pain responses in newborns undergoing routine heelsticks. Forty-eight healthy infants were assigned to four groups, an own mother's breast milk odor group (Own MM), another mother's breast milk odor group (Other MM), a for...

journal_title：Neuroscience research

authors： Nishitani S,Miyamura T,Tagawa M,Sumi M,Takase R,Doi H,Moriuchi H,Shinohara K

更新日期：2009-01-01 00:00:00

abstract：:Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...

journal_title：Neuroscience research

authors： Matsui H

更新日期：2017-07-01 00:00:00

abstract：:Whole-cell recordings were performed to examine the morphological properties of electrophysiologically classified area postrema (AP) neurons in rat brain slices. Using electrophysiological criteria, AP neurons were subdivided into three groups: (1) cells displaying both the hyperpolarization-activated cation current (...

journal_title：Neuroscience research

authors： Funahashi M,Mitoh Y,Akaike T,Matsuo R

更新日期：2006-01-01 00:00:00

abstract：:Amyloid-beta (Aβ) peptides, Aβ 1-42 (Aβ42) and Aβ43 in particular, cause neurotoxicity and cell death in the brain of Alzheimer's disease (AD) at higher concentrations. Carnosic acid (CA), a phenolic diterpene compound in the labiate herbs rosemary and sage, serves as an activator for neuroprotective and neurotrophic ...

journal_title：Neuroscience research

authors： Meng P,Yoshida H,Tanji K,Matsumiya T,Xing F,Hayakari R,Wang L,Tsuruga K,Tanaka H,Mimura J,Kosaka K,Itoh K,Takahashi I,Kawaguchi S,Imaizumi T

更新日期：2015-05-01 00:00:00

abstract：:A mixture of peptidase inhibitors increased the magnitude of the saphenous nerve-evoked slow depolarization of a lumbar ventral root and prolonged the similarly evoked inhibition of monosynaptic reflex (MSR) in the isolated spinal cord of the newborn rat in the presence of naloxone. The saphenous nerve-evoked MSR inhi...

journal_title：Neuroscience research

authors： Yanagisawa M,Yoshioka K,Kurihara T,Saito K,Seno N,Suzuki H,Hosoki R,Otsuka M

更新日期：1992-12-01 00:00:00

abstract：:It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...

journal_title：Neuroscience research

authors： Baginskas A,Kuraite V,Kuras A

更新日期：2012-09-01 00:00:00

abstract：:We used functional magnetic resonance imaging in 18 normal volunteers to determine whether there is separate representation of syntactic, semantic, and verbal working memory processing in the left inferior frontal gyrus (GFi). We compared a sentence comprehension task with a short-term memory maintenance task to ident...

journal_title：Neuroscience research

authors： Uchiyama Y,Toyoda H,Honda M,Yoshida H,Kochiyama T,Ebe K,Sadato N

更新日期：2008-07-01 00:00:00

abstract：:In the vertebrate nervous system, glutamate (Glu) receptors are generally known to cause depolarizing responses. We report here a novel type of Glu response in Purkinje neurons of mouse cerebellar slices, namely glutamate-induced hyperpolarization (GH). This response is not due to activation of inhibitory interneurons...

journal_title：Neuroscience research

authors： Inoue T,Miyakawa H,Ito K,Mikoshiba K,Kato H

更新日期：1992-12-01 00:00:00

abstract：:Interleukin-6 (IL-6, human recombinant) promoted the survival of catecholaminergic neurons from fetal and postnatal rat midbrains as assessed by an immunohistochemical staining for tyrosine hydroxylase (TH) in culture using a chemically defined medium. The maximal dose of IL-6 for the cell survival of postnatal P15 ra...

journal_title：Neuroscience research

authors： Kushima Y,Hama T,Hatanaka H

更新日期：1992-05-01 00:00:00

abstract：:Because a potential treatment for brain injuries could be elevating magnesium ions (Mg(2+)) intracerebrally, we characterized the effects of elevating external Mg(2+) in cultures of neonatal murine brain-derived neural stem/progenitor cells (NSCs). Using a crystal violet assay, which avoids interference of Mg(2+) in t...

journal_title：Neuroscience research

authors： Vennemeyer JJ,Hopkins T,Kuhlmann J,Heineman WR,Pixley SK

更新日期：2014-07-01 00:00:00

abstract：:The coexistence of varying combinations of substance P (SP), somatostatin (SOM), thyrotropin-releasing hormone (TRH) and met-enkephalin-Arg-Gly-Leu (ENK) with 5-hydroxytryptamine (5-HT) as semiquantitatively revealed by immunocytochemistry in neuronal perikarya of the raphe pallidus et obscurus in the guinea-pig was a...

journal_title：Neuroscience research

authors： Chiba T,Masuko S

更新日期：1989-10-01 00:00:00

abstract：:Alzheimer's disease (AD) patients tend to have increased plasma levels of homocysteine. However, it is unclear whether abnormality in homocysteine levels is a primary cause of Alzheimer's disease or a disease marker. In order to investigate the relative impact of Alzheimer's disease on plasma homocysteine levels, tota...

journal_title：Neuroscience research

authors： Santiard-Baron D,Aupetit J,Janel N

更新日期：2005-12-01 00:00:00

abstract：:In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...

journal_title：Neuroscience research

authors： Liberini P,Valerio A,Moretto G,Rizzonelli P,Memo M,Rizzuto N,Spano PF

更新日期：1995-05-01 00:00:00

abstract：:One important aspect of empathy is a "resonance mechanism", which includes emotional cue detection, facial mimicry (measured by electromyography, EMG) and a specific cortical response. This study explored the convergence of these three measures of affective empathy. The twenty students who took part in the study were ...

journal_title：Neuroscience research

authors： Balconi M,Bortolotti A,Gonzaga L

更新日期：2011-11-01 00:00:00

abstract：:Changes in the features of responses of cortical taste neurons were studied in granular insular (GI) and dysgranular insular (DI) areas of urethane-anesthetized SD rats of four age groups (4-10, 14-20, 25-35 and > 90 days). Stimuli included four basic taste stimuli, 0.1 M NH4Cl, and the water extract of a food pellet,...

journal_title：Neuroscience research

authors： Ogawa H,Hasegawa K,Ohgushi M,Murayama N

更新日期：1994-06-01 00:00:00

abstract：:1-methyl-4-phenylpyridinium ion (MPP(+)), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of intracellular reactive oxygen species (ROS) level and apoptotic death. Salvianic acid A (SA), isolated from the Chinese...

journal_title：Neuroscience research

authors： Wang XJ,Xu JX

更新日期：2005-02-01 00:00:00

abstract：:The older neurocentric view of the central nervous system (CNS) has changed radically with the growing understanding of the many essential functions of astrocytes. Advances in our understanding of astrocytes include new observations about their structure, organization, function and supportive actions to other cells. A...

journal_title：Neuroscience research

authors： Barreto GE,Gonzalez J,Torres Y,Morales L

更新日期：2011-10-01 00:00:00

abstract：:Many studies on long-term potentiation (LTP) in hippocampal region CA1 focus on receptor-mediated events that are often presumed to be linked to postsynaptic processes. Whereas it is now well-known that LTP consists of multiple components involving increases in postsynaptic responsiveness as well as enhanced presynapt...

journal_title：Neuroscience research

authors： Hicks TP,Ito KI

更新日期：1996-01-01 00:00:00

abstract：:Reflex blinking provides a useful experimental tool for various functional studies on the peripheral and central nervous system, yet the neuronal circuitry underlying this reflex is not precisely known. In the present study, we investigated as to whether neurons in the reticular formation and rostral cervical spinal c...

journal_title：Neuroscience research

authors： Smit AE,Buisseret P,Buisseret-Delmas C,De Zeeuw CI,VanderWerf F,Zerari-Mailly F

更新日期：2006-12-01 00:00:00

abstract：:To study the contribution of retinal and cortical afferents to the patterns of glutamate- and homocysteate-like immunoreactivities in dorsal lateral geniculate, combined retinal and cortical ablations were performed in rats. In controls, glutamate immunoreactivity was in terminal-like dots and neurons. Homocysteate im...

journal_title：Neuroscience research

authors： Grandes P,Mateos JM,Azkue J,Sarría R,Cuénod M,Streit P

更新日期：1997-04-01 00:00:00

abstract：:GABAergic characteristics of transcallosal activity of cat pyramidal tract neurons (PTNs) and non-PTNs (nPTNs) were studied with stressing on GABAB receptors. PTNs and nPTNs were further classified into group 1 (< 10 ms) and group 2 (> 10 ms) based on the latency upon transcallosal stimulation. However, mainly the res...

journal_title：Neuroscience research

authors： Chowdhury SA,Kawashima T,Konishi T,Matsunami K

更新日期：1996-12-01 00:00:00

abstract：:Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...

journal_title：Neuroscience research

authors： Sudo K,Ito H,Iwamoto I,Morishita R,Asano T,Nagata K

更新日期：2006-12-01 00:00:00

abstract：:Nerve growth factor (NGF)-like immunoreactivity was demonstrated in the rat pituitary intermediate lobe by indirect immunofluorescence method using antisera specific to beta-NGF isolated from adult male mouse submaxillary salivary gland. Co-culture of frozen or fresh intermediate lobes with newborn rat superior cervic...

journal_title：Neuroscience research

authors： Soinila S,Lakshmanan J,Lahtinen T

更新日期：1988-12-01 00:00:00

abstract：:The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles. The experiments were performed on 7 ...

journal_title：Neuroscience research

authors： Djupsjöbacka M,Johansson H,Bergenheim M,Sjölander P

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD). METHOD:EEGs were recorded from 22 AD patients and 23 age-matched healthy...

journal_title：Neuroscience research

authors： Park YM,Che HJ,Im CH,Jung HT,Bae SM,Lee SH

更新日期：2008-10-01 00:00:00

abstract：:It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...

journal_title：Neuroscience research

authors： Kamiji NL,Yamamoto K,Hirasawa H,Yamada M,Usui S,Kurokawa M

更新日期：2012-04-01 00:00:00

abstract：:Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26...

journal_title：Neuroscience research

authors： Kubota T,Uchiyama M,Suzuki H,Shibui K,Kim K,Tan X,Tagaya H,Okawa M,Inoue S

更新日期：2002-02-01 00:00:00

abstract：:Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO). Hamster SCO consists of the ependymal and hypendymal cell layers, the latter being arranged as ro...

journal_title：Neuroscience research

authors： Tsai MH,Wu CH,Chen WP,Shieh JY,Wen CY

更新日期：2003-09-01 00:00:00

abstract：:NMDA receptors play an important functional role in the neuron excitability and plasticity. The conditions and consequences of their activation are of interest for many neuroscientists. This investigation was designed to explore an activation of the NMDA receptors of frog tectal neurons in vivo by a burst of spikes of...

journal_title：Neuroscience research

authors： Kuras A,Baginskas A,Batuleviciene V

更新日期：2006-04-01 00:00:00