Abstract:
:Changes in the features of responses of cortical taste neurons were studied in granular insular (GI) and dysgranular insular (DI) areas of urethane-anesthetized SD rats of four age groups (4-10, 14-20, 25-35 and > 90 days). Stimuli included four basic taste stimuli, 0.1 M NH4Cl, and the water extract of a food pellet, applied to the entire oral cavity. At the age of 4-10 days, taste neurons showed no spontaneous discharge, and most responded to NH4Cl in a phasic fashion. In older age groups, however, there was a spontaneous discharge, and tonic taste responses were evident; some responded better to the four basic stimuli and to the food than to NH4Cl. With only a few days' difference in age, inhibitory responses were also noted in both areas. Average taste responses increased or decreased at different ages, depending on the type of taste stimulus and recording area. When taste responses were plotted against the four basic taste stimuli in the order of sucrose, NaCl, HCl and quinine along the abscissa, some neurons showed double-peaked response profiles. This suggests the convergence and mutual inhibition of afferents at single cortical neurons. The fraction of neurons with double-peaked response profiles increased at the age of 25-35 days in both areas. Neurons in rats aged 25-35 days were predominantly sensitive to either NH4Cl or NaCl, or to either food or sucrose. Neurons in rats of other ages, during the preweanling and the adult stages, tended to respond to both these stimuli. Our observations suggest that cortical taste neurons develop in the rat brain in accordance with the maturation of both the taste receptors and the neural networks.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Ogawa H,Hasegawa K,Ohgushi M,Murayama Ndoi
10.1016/0168-0102(94)90082-5subject
Has Abstractpub_date
1994-06-01 00:00:00pages
407-17issue
4eissn
0168-0102issn
1872-8111pii
0168-0102(94)90082-5journal_volume
19pub_type
杂志文章abstract::In the visual system, the afferent axons from the dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) show significant activity-dependent plasticity in early postnatal life. To determine whether activity-dependent plasticity operates also in feedback projections from V1 to dLGN, we inactivated c...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.02.002
更新日期:2009-05-01 00:00:00
abstract::The NRG1 growth factor and ERBB4 receptor have been identified as leading schizophrenia risk genes. Although NRG1 and ERBB4 have been shown to modulate neuronal functions involved in schizophrenia, including both GABAergic and glutamatergic synapses, the exact molecular mechanisms remain poorly understood. Here we inv...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2011.02.009
更新日期:2011-06-01 00:00:00
abstract::Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of demyelination. MS is believed to be an autoimmune disorder mediated by activated immune cells such as T- and B-lymphocytes and...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/s0168-0102(03)00127-5
更新日期:2003-08-01 00:00:00
abstract::It has been indicated that Pyk2/Src signaling pathway is involved in modulation of N-methyl-D-aspartate-type (NMDA) glutamate receptor activity. Lithium protects against glutamate-induced excitotoxicity in cultured neurons and in animal models of diseases. The neuroprotection against excitotoxicity afforded by lithium...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.04.004
更新日期:2004-08-01 00:00:00
abstract::Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00911-c
更新日期:1995-07-01 00:00:00
abstract::Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00036-6
更新日期:2002-07-01 00:00:00
abstract::In this review, we describe recent experimental observations and model simulations in the research subject of brain-machine interface (BMI). Studies of BMIs have applied decoding models to extract functional characteristics of the recorded neurons, and some of these have more focused on adaptation based on neural oper...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2020.03.008
更新日期:2020-07-01 00:00:00
abstract::Adult mammals could spontaneously achieve a partial sensory-motor recovery after spinal cord injury, by mechanisms including synaptic plasticity. We previously showed that this recovery is associated to the expression of synapsin-I, and that sonic hedgehog and Notch-1 could be also involved in plasticity. The role of ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.04.010
更新日期:2012-07-01 00:00:00
abstract::Mature rat spinal cord cDNA libraries constructed in lambda gt10 and lambda ZAPII were screened with an oligonucleotide probe (39 mer), and 4 clones that possess DNA-inserts encoding a glycine receptor subunit were obtained. The cloned cDNAs were used to reconstruct the nucleotide sequence of the full-length open read...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90064-6
更新日期:1991-06-01 00:00:00
abstract::The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.01.011
更新日期:2020-01-01 00:00:00
abstract::The facilitatory masseteric muscle response (FMR) elicited by polyurethane foam strip application between the opposing molars during cortically-induced rhythmic jaw movements (CRJMs) was induced earlier than masticatory force onset. The occurrence of this early response of the FMR (e-FMR) could not be explained by a s...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(00)00192-9
更新日期:2001-01-01 00:00:00
abstract::The effects of iontophoretically applied (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), an agonist of metabotropic glutamate receptors, were examined in rat cerebellar Purkinje cells in vivo. Multibarrel electrodes were used for extracellular recordings of spontaneous single unit discharges and iontop...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(93)90057-w
更新日期:1993-12-01 00:00:00
abstract::Using a mouse Thy-1 allelic system (an AKR strain of Thy-1.1 was used as the host and a BALB/c strain of Thy-1.2 as the graft), characteristics of transplant-to-host axon projection and synapse formation of the olfactory bulb (OB) were studied in the hippocampal formation by immunohistochemical and ultrastructural exa...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00979-5
更新日期:1995-12-01 00:00:00
abstract::Glutamate receptor subtypes mediating excitatory synaptic neurotransmission in the cerebellar cortex are briefly reviewed from molecular biological, electrophysiological and pharmacological points of view. In particular, molecular biological findings of a novel family of AMPA-selective glutamate receptors are introduc...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/0168-0102(91)90023-r
更新日期:1991-01-01 00:00:00
abstract::This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00245-0
更新日期:2001-08-01 00:00:00
abstract::Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.11.002
更新日期:2007-03-01 00:00:00
abstract::We examined the effects of the gravitational vertical on the perception of reversible figures. Each reversible figure had two interpretations depending on whether it was viewed vertically in one orientation or upside down. When it was presented horizontally, the two interpretations alternated. Subjects were required t...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.02.014
更新日期:2006-06-01 00:00:00
abstract::alpha-Mannosidosis is a lysosomal storage disease resulting from a deficiency of the enzyme alpha-D-mannosidase. A major feature of alpha-mannosidosis is progressive neurological decline, for which there is no safe and effective treatment available. We have a guinea pig model of alpha-mannosidosis that models the huma...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.06.010
更新日期:2005-10-01 00:00:00
abstract::Until recently, little was known about the rostral part of the dorsal premotor cortex (PMdr). In the present study, somatotopical representations of the PMdr were electrophysiologically identified in the macaque monkey, and the distribution of corticostriatal input from the forelimb region of the PMdr was analyzed in ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2003.09.006
更新日期:2004-01-01 00:00:00
abstract::Excitatory synaptic transmission from two input systems to hippocampal CA3 pyramidal neurons was investigated by the whole-cell patch-clamp technique for thin slice preparation, with special reference to long-term potentiation (LTP) in these systems. Excitatory postsynaptic currents (EPSCs) evoked by fimbrial stimulat...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90070-f
更新日期:1991-11-01 00:00:00
abstract::Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2014.02.003
更新日期:2014-04-01 00:00:00
abstract::Development of neurofibrillary tangles (NFTs) is a pathological hallmark in various neurodegenerative disorders including Alzheimer's disease (AD). Recently, we identified a granular tau oligomer having a pre-filamentous structure. To determine the role of this oligomer in NFT formation, we quantified the amount of gr...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.11.009
更新日期:2006-03-01 00:00:00
abstract::Axonal transport is the specialized and well-developed intracellular transport system for regulated and/or long-distance transport based on generalized cellular machineries. Among them, slow axonal transport conveys cytoplasmic proteins. The motor molecule, the nature of transporting complex and the transport regulati...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2003.08.005
更新日期:2003-12-01 00:00:00
abstract::L-glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system and has also been implicated as a potent neurotoxin. To ensure a high signal-to-noise ratio during synaptic transmission and to prevent neuronal damage that might occur as a result of excessive activation of glutamate recept...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/s0168-0102(00)00104-8
更新日期:2000-05-01 00:00:00
abstract::Men and women exhibit differences in sexual behavior. This indicates that neural circuits within the central nervous system (CNS) that control sexual behavior differ between the sexes, although differences in behavior are also influenced by sociocultural and hormonal factors. Sexual differentiation of the body and bra...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2011.11.002
更新日期:2012-02-01 00:00:00
abstract::To elucidate biophysical mechanisms underlying the Zn2+ block on the low-threshold T-type Ca2+ current (I(T)), we examined the Zn(2+)-induced alterations of gating properties of I(T) of a rat thalamic relay neuron and of alpha1G channels expressed in HEK-293 cells, using a whole-cell voltage clamp technique. The effec...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.12.005
更新日期:2010-04-01 00:00:00
abstract::The disposition of the facial vibrissae of the mouse is represented as a matrix-like array of cell aggregates in rows and columns at every station of the whisker-to-barrel pathway. In order to evaluate the role of each station in this pathway, lesions were made in the facial vibrissae of the mystacial group on P0-P3, ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00969-Z
更新日期:1995-11-01 00:00:00
abstract::Swelling of brain cells is one of the physiological responses associated with neuronal activation. To investigate underlying mechanisms, we analyzed interactions between changes in cell volume and synaptic responses in the hippocampal slices from rodents. Swelling within the CA1 area was detected as increases in trans...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00153-0
更新日期:2002-11-01 00:00:00
abstract::Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Chicken Bsg (HT7/neurothelin/ 5A11) is expressed in neuroblasts, but disappears from neurons after a specific stage of cytodifferentiation, and becomes restrictedly expressed in the capillary endothelium in the adult brain. We s...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00119-3
更新日期:1998-01-01 00:00:00
abstract::A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2011.05.001
更新日期:2011-08-01 00:00:00